Clinical trials: Veterans
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Pneumonia
Reducing Length of Stay for Veterans Hospitalized With Pneumonia
This is a pilot study to implement a computer based intervention to safely reduce length of hospital stay and time to conversion to oral antibiotics for patients with pneumonia.
- Trial name
- NCT01068548
- Testing
- reminder
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Helicobacter Pylori
Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans
The primary objective of this study is to compare the Helicobacter pylori (H. pylori) eradication rate following empiric bismuth-based quadruple therapy (BQT) versus a personalized H.
- Trial name
- VA EradicateHP (NCT07104318)
- Testing
- Bismuth quadruple therapy with optimized proton pump inhibitor (PPI), Bismuth quadruple therapy with standard proton pump inhibitor (PPI), Clarithromycin triple therapy with optimized proton pump inhibitor (PPI)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic; Mental Disorders
PTSD Treatment for Veterans With Serious Mental Illness to Improve Functional Outcomes
PTSD is common among Veterans with serious mental illness (SMI). Co-occurring PTSD and SMI lead to poorer mental health and physical functioning than either diagnosis alone.
- Trial name
- NCT05674617
- Testing
- Written Exposure Therapy, PTSD Education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Insomnia Chronic, Posttraumatic Stress Disorder
Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder: Proof of Concept
This is a proof-of-concept, open-label trial of pimavanserin 34mg at bedtime for 6 weeks in Veterans with insomnia and Posttraumatic Stress Disorder.
- Trial name
- NCT04809116
- Testing
- Pimavanserin
- Where
- United States
- Sponsor
- Baylor College of Medicine
COPD, Depression
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk.
- Conditions
- COPD, Depression, Anxiety
- Trial name
- NCT04953806
- Testing
- Step-CBT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Depression, Stress Disorders, Post-Traumatic
Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy.
- Trial name
- NCT07202325
- Testing
- Resilience Training for Veterans (REST-V), Usual resources
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Prediabetes, Obesity
Veterans Achieving Weight Loss and Optimizing Resilience-Using Protein
Diabetes is a major health concern in obese older Veterans, especially in those who are African American. The negative impact of diabetes on muscle and physical function contributes to metabolic as well as physical decline and is…
- Trial name
- VALOR-UP (NCT03835416)
- Testing
- Foods rich in high quality protein
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Alcoholism, Substance-related Disorders
Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services
Homeless Veterans with substance use disorders (SUDs) are a major group served by VA and are heavily represented in VA housing. VA recently adopted a 'Housing First' approach emphasizing rapid housing placement to initiate…
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- NCT02233738
- Testing
- Group Motivational Interviewing (GMI), Control Treatment Condition (CT)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- VA Office of Research and Development
Obese Patients, Tobacco Use
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population.
- Conditions
- Obese Patients, Tobacco Use, Veterans, Family History of Esophageal Cancer
- Trial name
- NCT06746623
- Testing
- Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Louis Stokes VA Medical Center
Chronic Pain
MIVetsCan: Can-Coach Trial (Phase 2)
The goal of the MIVetsCan Can-Coach Trial is to test four coaching sessions to help Veterans with chronic pain use their own cannabis products more effectively to manage pain and related symptoms.
- Trial name
- NCT06283862
- Testing
- Educational Session
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- University of Michigan
Overdose, Opioid Use Disorder
Community-based Education, Navigation, and Support Intervention for Military Veterans
Military veterans in the U.S. represent one of the populations most disproportionately impacted by the current opioid crisis. Veterans who use opioids and are not connected to the VA healthcare system have high rates of…
- Conditions
- Overdose, Opioid Use Disorder, HIV Infections
- Trial name
- CENS (NCT05343169)
- Testing
- Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York University
Post-traumatic
Exercise and PTSD in Older Veterans
The purpose of this study is to examine whether posttraumatic stress disorder (PTSD) symptoms impact adherence to a 12-week physical activity program and whether exercise can help improve PTSD symptoms and health outcomes in…
- Trial name
- NCT02295995
- Testing
- Exercise as an Adjuvant Therapy for Veterans with PTSD
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) Gulf War Study
Recently, concern has arisen regarding a possible elevated occurrence of ALS among veterans who served in the Persian Gulf during Operations Desert Shield (August 2, 1990 - January 15, 1991), Desert Storm (January 16, 1991 …
- Trial name
- NCT00007722
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- US Department of Veterans Affairs
Opioid Use Disorder, HIV
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans
Opioid use disorder (OUD) confers a higher risk of acquiring and transmitting infectious diseases, which may have long-term health consequences in Veterans.
- Conditions
- Opioid Use Disorder, HIV, Hepatitis C Virus, Gonorrhea
- Trial name
- NCT06766331
- Testing
- Integrated care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Insomnia, Mental Health Functioning
Computerized Cognitive Behavioral Treatment for Insomnia: Improving Rural Veteran Access to Evidence-Based Treatment to Reduce Suicide Risk (R-Vets Sleep)
Insomnia is a major problem among veteran populations. Insomnia impacts physical and mental health functioning and is associated with reduced quality of life.
- Conditions
- Insomnia, Mental Health Functioning, Physical Health Functioning
- Trial name
- R-Vets Sleep (NCT03365024)
- Testing
- Computerized Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Suicide, Suicidal Ideation
Intervening to Reduce Suicide Risk in Veterans With Substance Use Disorders
The purpose of this study is to evaluate the impact of a Cognitive Behavioral Therapy (CBT) intervention compared to a Supportive Psycho-educational Control (SPC) condition in reducing the frequency and intensity of suicidal…
- Conditions
- Suicide, Suicidal Ideation, Substance-Related Disorders
- Trial name
- NCT02439762
- Testing
- Cognitive Behavioral Therapy (CBT), Supportive Psycho-education (SPC)
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Diabetes, Type 2 Diabetes (T2DM)
CGM Use in Non-insulin Patients With DM2
The U.S. Food and Drug Administration (FDA) has approved multiple Continuous Glucose Monitoring (CGM) devices from different manufacturers to be used as an aide in patients with type 1 and type 2 diabetes who require medications…
- Conditions
- Diabetes, Type 2 Diabetes (T2DM), Obesity Type 2 Diabetes Mellitus, Non Insulin Dependent Diabetes Mellitus
- Trial name
- CGM-DWI (NCT07128342)
- Testing
- CGM Group, FSBG group
- Volunteers
- 100 people
- Sponsor
- Milwaukee VA Medical Center
Suicide
Veterans Coping Long-term With Active Suicide
The proposed study seeks to test the efficacy of an intervention to reduce suicide behaviors in Veterans. The Veterans Coping Long Term with Active Suicide Program (CLASP-VA) is an innovative, telephone-based intervention that…
- Trial name
- CLASP-VA (NCT01894841)
- Testing
- Coping Long Term with Active Suicide (CLASP), Safety Assessment and Follow Up Evaluation
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Peripheral Artery Disease
Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD
The present study aims to increase Veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of Veterans with PAD.
- Trial name
- MOVE-IT (NCT05048979)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
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