Clinical trials: Vibration
Amyotrophic Lateral Sclerosis
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression.
- Trial name
- IRM-SLA (NCT04691011)
- Testing
- Muscular MRI, Electrophysiological exam, Brain MRI
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Type2diabetes
Effects of Metformin Therapy on Pancreatic and Hepatic Fat Content in Patients of Type 2 Diabetes Mellitus
A sample size of 15 patients with T2DM visiting Fortis C DOC Hospital will be recruited with informed, written consent and will be requested to answer a validated questionnaire in a language known to them (English/Hindi).
- Trial name
- NCT05939921
- Testing
- Metformin
- Where
- India
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Rotator Cuff Tears
Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
The primary objective of this prospective randomized controlled trial is to compare pain and functional outcomes between two surgical modalities for irreparable rotator cuff tears as measured by the pain visual analog scale…
- Trial name
- NCT04742452
- Testing
- Superior Capusular Reconstruction, Partial Rotator Cuff Repair
- Where
- 3 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Marfan Syndrome
Towards Optimal Treatment of Marfan Syndrome
The purpose of this study is to determine whether new magnetic resonance imaging techniques can be used as a biomarker of aortic disease severity in patients with Marfan syndrome.
- Trial name
- TOWER (NCT05944614)
- Testing
- Magnetic Resonance imaging (MRI) examination
- Where
- 4 sites in Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cancer of Lymph Node
Clinical and Technical Feasibility of a Ultrasuperparamagnetic Nanoparticle Iron Oxide (USPIO)-Enhanced Magnetic Resonance Lymph Node Imaging
The goal of this clinical research study is to learn if the drug Feraheme ® (ferumoxytole) helps researchers most clearly to "see" cancerous lymph nodes on an MRI scan.
- Trial name
- NCT01815333
- Testing
- Feraheme, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Itch; Athlete
The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise
Intense itch on the legs sometimes associated with redness can be adverse effects of whole body vibration (WBV) according to own observations and numerous posts in non-professional online-blogs.
- Trial name
- VIBRA (NCT03455036)
- Testing
- Whole body vibration training
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Stroke
Physiology of Interregional Connectivity in the Human Brain
The purpose of this study is to understand the physiology of connectivity between cortical regions in the human brain in healthy participants and in patients with white matter lesions.
- Conditions
- Healthy, Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT03723434
- Testing
- Single-pulse transcranial magnetic stimulation (spTMS), Paired associative stimulation (PAS), Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Sarcopenia, Frailty at Older Adults
Targeting Sarcopenia and Frailty: Multicomponent Exercise With Focal Muscle Vibration
This study aimed to evaluate the efficacy of multicomponent exercises (aerobic exercises, strength exercises, and balance exercises), individualized with the application of a focal muscle vibration machine at the lower…
- Conditions
- Sarcopenia, Frailty at Older Adults, Cognitive Impairment, Adherence
- Trial name
- NCT07049809
- Testing
- Focal Muscle Vibration, Multicomponent Exercise
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Brain Arteriovenous Malformations
Language Function Reorganization in Patients With Arteriovenous Malformations
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the…
- Trial name
- NCT07537504
- Testing
- MRI
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Breast Cancer
Diffusion Weighted MR Imaging of the Breasts in Women at High Risk of Breast Cancer: A Pilot Study
Purpose: The purpose of this pilot study is to evaluate whether MRI of the breasts with diffusion-weighted MR imaging can identify features more specific for breast cancer in women at high-risk of developing breast cancer.
- Trial name
- NCT01938157
- Testing
- Diffusion-weighted MR imaging
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Range of Motion, Running
Effect of Whole-body Vibration on the Ankle Joint, Plantar Pressure, and Running Paramethers
The main purpose of this study was the assessment of whole-body vibration warm-up, modified drop jumps, and combination of both on the range of motion of dorsiflexion in the ankle joint and running time.
- Conditions
- Range of Motion, Running, Gait
- Trial name
- NCT06227312
- Testing
- LADY 1 Pro, New Life Balance, exercises
- Where
- Poland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Migraine Without Aura, Acupuncture Therapy
Brain Connectome for Acupuncture-treated Migraine Patients
Acupuncture has been a means of treating headaches and migraine since 2002 and is now a World Health Organisation-recognized prophylactic treatment for migraine.
- Trial name
- ACU-BRAIN (NCT04157192)
- Testing
- Real acupuncture
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
H-reflex, Spinal Reflexes
H-Reflex Suppression by Bone Myoregulation Reflex During Mechanical Loading in Standing Humans
This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing…
- Conditions
- H-reflex, Spinal Reflexes, Posture, Weight-Bearing
- Trial name
- BMR-HREF (NCT07043595)
- Testing
- Whole-Body Vibration (WBV)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Breast Cancer
Opportunistic Breast Cancer Screening Using Non-Contrast Chest CT
The goal of this observational study is to evaluate the feasibility and effectiveness of using non-contrast chest computed tomography scans for opportunistic breast cancer screening, and to further compare its diagnostic…
- Trial name
- OPBCS-CT (NCT07557654)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Chronic Low Back Pain, Diabetic Peripheral Neuropathy
MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
This study is designed to assess: Hypothesis #1: That there is a significant central pain component in a distinct subset of patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful diabetic…
- Conditions
- Chronic Low Back Pain, Diabetic Peripheral Neuropathy, Knee Osteoarthritis
- Trial name
- NCT01620775
- Testing
- MRIs, Pain testing
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Ulcerative Colitis, Irritable Bowel Syndrome
Cerebral Resonance Magnetic Imaging During Rectal Distention
Irritable bowel syndrome is responsible for chronic abdominal pain, diarrhea and/or constipation. It is a very frequent problem. However, the exact cause of irritable bowel syndrome remains unknown.
- Trial name
- NCT00213330
- Testing
- rectal distension
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Pain
The Effect of Vibration Stimulation on Intramuscular Injection Pain and Patient Satisfaction: A Single-blind, Randomized Cross-over Study
Intramuscular (IM) injection is the most frequently used nursing practice in the clinic.1 16 billion treatments are performed through injection per year all over the world.
- Trial name
- NCT04411992
- Testing
- Vibrating Device
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aging, Exercise
Effects of Exercise Intervention on Aging-related Motor Decline
The purpose of this research study is to test whether differing levels of physical fitness affects patterns of motor dexterity and brain activity that have been shown to differ due to aging.
- Trial name
- EIAMD (NCT01787292)
- Testing
- Stretching Exercise Intervention, Aerobic Exercise Intervention, Self Monitoring
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
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