Clinical trials: Viral Load
HIV Infections
Effectiveness of Treating HIV-Positive Patients With an HIV Vaccine (Remune)
The purpose of this study is to see if it is effective to add an HIV vaccine (Remune) to the anti-HIV drug combination of Combivir (zidovudine plus lamivudine) and nelfinavir.
- Trial name
- NCT00005002
- Testing
- Lamivudine/Zidovudine, HIV-1 Immunogen, Nelfinavir mesylate
- Where
- United States
- Volunteers
- 688 people
- Sponsor
- Agouron Pharmaceuticals
HIV
Study of the Influence of Vaccination in HIV Viral Load and Immunologic Responses Against HIV
The purpose of this study is to determine whether an immunization schedule is beneficial to HIV-infected patients with CD4 recount over 500 cells/mm3 and undetectable viral load.
- Trial name
- NCT00329251
- Testing
- Hepatitis A, Hepatitis B, Influenza
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Clinic of Barcelona
HCV Recurrence After Liver Transplantation
Legalon SIL for the Treatment of HCV Recurrence in Liver Transplanted Patients
Orthotopic liver transplantation (OLT) is the treatment of choice for patients with Hepatitis C Virus (HCV) infection and end-stage liver disease or hepatocellular carcinoma; infection of the graft and hepatitis C recurrence is…
- Trial name
- NCT01535092
- Testing
- Silibinin
- Volunteers
- 14 people
- Sponsor
- Rottapharm
HIV Infections
Study of HIV Patients With Undetectable Viral Load and Abnormal Lipids Switching to Atazanavir/Ritonavir
Patients with HIV who are virologically suppressed on a lopinavir/ritonavir combination highly active antiretroviral therapy (HAART) regimen but with elevated non-HDL cholesterol are randomized to remain on lopinavir/ritonavir or…
- Trial name
- NCT00120393
- Testing
- atazanavir/ritonavir +2 NRTIs (immediate Switch Group), LPV/r +2 NRTIs (Delayed/optional Switch Group)
- Where
- 14 sites in United States, Canada
- Volunteers
- 192 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection
The purpose of this study is to compare the effectiveness of various combinations of anti-HIV drugs in HIV-positive men and women.
- Trial name
- NCT00000919
- Testing
- Indinavir sulfate, Lamivudine/Zidovudine, Ritonavir
- Where
- 80 sites in United States, Italy and 1 more
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected With HIV
The purpose of this study is to find out whether these powerful combinations of anti-HIV drugs are safe and effective for use in patients in the early stages of HIV infection and to find out how patients' immune systems react to…
- Trial name
- NCT00001119
- Testing
- Tetanus Toxoid Vaccine, Indinavir sulfate, Lamivudine/Zidovudine
- Where
- 12 sites in United States, Australia
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
SARS-CoV Infection
Efficacy and Safety of Ozonised Oil (HOO) in COVID-19 Patients
The anti-viral efficacy of ozone against RNA viruses is already established. Ozone gas have been already proposed as possible therapy for Covid-19 infection with insofar limited success.
- Trial name
- HOO-COVID (NCT04651387)
- Testing
- Ozonized oil (HOO
- Sponsor
- Neuromed IRCCS
COVID-19
The Efficacy of Oral Antiseptics Against COVID-19
In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.
- Trial name
- NCT05214196
- Testing
- Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ataturk University
HIV, Alcohol Use
Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Alcohol use is increasingly recognized as a key factor in morbidity and mortality among HIV-positive individuals and represents an important public health concern, given its associations with medication non-adherence, increases…
- Conditions
- HIV, Alcohol Use, Medication Adherence
- Trial name
- PLUS (NCT02390908)
- Testing
- Immediate PLUS intervention, Wait-list PLUS intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
HIV-1
Phase 1, Open-label, Single Dose Study to Examine Safety, Tolerability, Pharmacokinetics and Virologic Impact of VRC01LS or VRC07-523LS in HIV-infected Viremic Adults
Background: The human body uses antibodies as one way to help fight infection. VRC01LS and VRC07-523LS are antibodies directed against the HIV virus. Researchers want to see if they are safe and well tolerated.
- Trial name
- NCT02840474
- Testing
- VRC-HIVMAB080-00-AB, VRC-HIVMAB075-00-AB
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
Study of Adherence Effects and Clinical Outcomes of Kaletra Based HIV Antiviral Therapy
The purpose of this study is to evaluate the effects of adherence on HIV antiviral response to treatment regimens containing Kaletra or other HIV protease inhibitors.
- Trial name
- NCT00234962
- Testing
- Lopinavir/Ritonavir
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abbott
HIV, Major Depressive Disorder
CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in Cameroon
The purpose of this study is to adapt depression treatment intervention for HIV patients in Cameroon. The PI will validate a depression severity measure, adapt key elements of the intervention to the Cameroon context, train…
- Trial name
- ADEPT (NCT02156622)
- Volunteers
- 55 people
- Sponsor
- University of North Carolina, Chapel Hill
Acquired Immunodeficiency Syndrome, HIV Infection
Clinic-based ART Diagnostic Evaluation
The study is funded through the Office of the Global AIDS Coordinator (OGAC #KE-07-0044). The purpose of this study is two-fold.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Infection, RNA Virus Infections, Virus Diseases
- Trial name
- CLADE (NCT01791556)
- Testing
- HIV-1 viral load testing
- Where
- Kenya
- Volunteers
- 820 people
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
COVID-19
Povidone-Iodine Oral Rinse Study
This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals.
- Trial name
- NCT05239598
- Testing
- Mouth rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
HIV Infections, HIV Wasting Syndrome
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children
The purpose of this study is to see how beginning or changing anti-HIV medications affects the body composition (weight, height, growth, body fat, and muscle mass, or fat and muscle distribution) of HIV-infected children.
- Conditions
- HIV Infections, HIV Wasting Syndrome, Lipodystrophy
- Trial name
- NCT00006064
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study of Abacavir Plus Indinavir Sulfate Plus Efavirenz in HIV-Infected Patients
To compare the virologic response between abacavir (ABC, 1592U89) regimens (drug vs. placebo) and between the 2 dosing regimens (BID vs.
- Trial name
- NCT00001086
- Testing
- Indinavir sulfate, Abacavir sulfate, Efavirenz
- Where
- 56 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Failure
IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load
Rationale: Parvovirus B19 (PVB19) persistence in the heart has been associated with progressive cardiac dysfunction and evolution to dilated cardiomyopathy.
- Trial name
- NCT00659386
- Testing
- Intravenous immunoglobulin therapy
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Immune Globulin, Prophylaxis, Telbuvidine, Vaccine
Efficacy of Antiviral Therapy in Pregnancy in Preventing Vertical Transmission of HBV in Mothers With a High Viral Load
Mother-to-child transmission (MTCT) is the most common route of hepatitis B virus (HBV) infection. After given standard immunoprophylaxis, MTCT still occurred in some infants born to a HBsAg positive mothers with high HBV DNA…
- Trial name
- NCT02253485
- Testing
- telbivudine
- Volunteers
- 600 people
- Sponsor
- Beijing Ditan Hospital
HIV Infections
A Study of Tucaresol in HIV-Infected Patients Who Are Taking Other Anti-HIV Drugs
The purpose of this study is to see if it is safe to give tucaresol to HIV-infected patients who are taking combination anti-HIV therapy (HAART).
- Trial name
- NCT00006209
- Testing
- Tucaresol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Aaron Diamond AIDS Research Center
Chronic Hepatitis B
Study of Entecavir for Reducing the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients
To analyze the incidence of liver cancer after entecavir administration among patients with low viral load and cirrhosis due to chronic hepatitis B infection.
- Trial name
- NCT04646928
- Where
- 11 sites in South Korea
- Volunteers
- 245 people
- Sponsor
- CHA University