Clinical trials: Viral Meningitis
Hiv, Meningitis, Meningococcal
Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population
This study aims to evaluate the immunogenicity, safety and tolerability of co-administration of vaccinations for meningitis B (Bexsero®) and meningitis ACWY (Menveo®) in adults and children aged 10-45 years living with HIV.
- Conditions
- Hiv, Meningitis, Meningococcal, HIV Infections
- Trial name
- ProPositive (NCT03682939)
- Testing
- Bexsero® (meningitis B vaccine), Menveo® (meningitis ACWY vaccine)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- St George's, University of London
Optic Neuritis, Transverse Myelitis
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
The Swiss-Ped-IBrainD is a national patient registry that collects information on diagnosis, symptoms, treatment, and follow-up of pediatric patients with an inflammatory brain disease in Switzerland.
- Conditions
- Optic Neuritis, Transverse Myelitis, Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- NCT05017142
- Where
- 13 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Tick Bites, Encephalitis
Evolving Diagnostic Approaches to Undocumented Lymphocytic Meningitis and Meningoencephalitis
Tick-borne encephalitis (TBE) is a viral infection transmitted by ticks. TBE is the third most common cause of encephalitis in France.
- Conditions
- Tick Bites, Encephalitis, Meningitis, Viral Encephalitis
- Trial name
- CHAN-MEE (NCT07186881)
- Testing
- Recommendation from the infectious diseases team
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Meningococcal Meningitis, Human Papillomavirus Infection
A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Conjugate Vaccine In Adolescents
This study will evaluate the safety and immune response of the Novartis Meningococcal ACWY conjugate vaccine when administered with Tdap and HPV vaccinations to healthy adolescents
- Conditions
- Meningococcal Meningitis, Human Papillomavirus Infection, Pertussis, Tetanus
- Trial name
- NCT00518180
- Testing
- Novartis Meningococcal ACWY Conjugate Vaccine, Tdap Vaccine
- Where
- Costa Rica
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Meningococcal Disease, Meningococcal Meningitis
Study to Evaluate the Safety and Immunogenicity of Combined Hepatitis A/B Vaccine With MenACWY-CRM Conjugate Vaccine
This study compares the safety and immunogenicity profile of combined hepatitis A/B vaccine given alone or concomitantly with MenACWY-CRM to healthy adults.
- Conditions
- Meningococcal Disease, Meningococcal Meningitis, Hepatitis A, Hepatitis B
- Trial name
- NCT01453348
- Testing
- MenACWY-CRM, Combined inactivated hepatitis A & recombinant hepatitis B, Recombinant hepatitis B vaccine
- Where
- 4 sites in Germany
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Neuropsychiatric Systemic Lupus Erythematosus, Systemic Lupus Erythematosus (SLE)
EG-501 for Cognitive Impairment in Neuropsychiatric SLE (NPSLE): Efficacy and Safety Study
Neuropsychiatric systemic lupus erythematosus with cognitive impairment (NPSLE-CI) is a serious, disabling, and potentially life-threatening manifestation of SLE, affecting up to 80% of patients with cognitive impairments ("brain…
- Conditions
- Neuropsychiatric Systemic Lupus Erythematosus, Systemic Lupus Erythematosus (SLE), Cognitive Impairment
- Trial name
- NCT07281105
- Testing
- EG-501
- Where
- 3 sites in United States
- Volunteers
- 131 people
- Sponsor
- Evergreen Therapeutics, Inc.
Acquired Immunodeficiency Syndrome, Histoplasmosis AIDS
Point of Care Tests to Identify Opportunistic Infections in Advanced HIV Patients in Mexico City
In Mexico City, the main cause of mortality among people living with HIV (PLHIV) continues to be opportunistic infections (OIs). Early detection of OIs allows their timely treatment and improves their prognosis.
- Conditions
- Acquired Immunodeficiency Syndrome, Histoplasmosis AIDS, Tuberculosis Infection, Cryptococcal Meningitis
- Trial name
- PREVALIOCDMX (NCT05685641)
- Testing
- Histoplasma Urine Antigen Lateral Flow Antigen test, Cryptococcal Lateral Flow Antigen test, Tuberculosis-lipoarabinomannan Lateral Flow Antigen test
- Where
- 4 sites in Mexico
- Volunteers
- 211 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology)
Adjunctive Doxycycline for Central Nervous System Tuberculosis
Although tuberculosis is now considered a treatable disease, central nervous system tuberculosis (CNS-TB) when managed with the current standard-of-care (SOC), still has mortality rates ranging from 30-50% even in tertiary…
- Conditions
- Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology), Tuberculosis, Central Nervous System, Tuberculosis; Meningoencephalitis (Etiology)
- Trial name
- DIRECT (NCT06446245)
- Testing
- Doxycycline, Anti Tuberculosis Drug, Adjunctive corticosteroid
- Where
- 6 sites in Indonesia, Malaysia and 1 more
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Meningitis, Cryptococcal, HIV Infections
Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
To compare the safety and effectiveness of fluconazole and amphotericin B, alone or in combination with flucytosine, as treatment for acute cryptococcal meningitis.
- Trial name
- NCT00002075
- Testing
- Flucytosine, Fluconazole, Amphotericin B
- Where
- United States
- Sponsor
- Pfizer
Hiv, Cryptococcal Meningitis
Platform Trial For Cryptococcal Meningitis (PLATFORM-CM)
Cryptococcal meningitis is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy.
- Trial name
- PLATFORM-CM (NCT06666322)
- Testing
- Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2
- Where
- 2 sites in Uganda
- Volunteers
- 2,000 people
- Sponsor
- David Boulware
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients
Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern.
- Trial name
- NCT02207647
- Testing
- no intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Meningococcal Disease, Meningococcal Meningitis
A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults
This study compares the safety and immunogenicity profile of several travel vaccines given alone or concomitantly with MenACWY-CRM to healthy adults.
- Conditions
- Meningococcal Disease, Meningococcal Meningitis, Typhoid, Yellow Fever
- Trial name
- NCT01466387
- Testing
- Typhoid Vi Polysaccharide Vaccine, Yellow Fever Vaccine, Japanese Encephalitis Vaccine
- Where
- 5 sites in Czechia, Germany
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Novartis
Encephalitis, Meningitis
Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment
Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways.
- Conditions
- Encephalitis, Meningitis, Meningoencephalitis, Next-Generation Sequencing
- Trial name
- NCT04946682
- Testing
- Types of etiological diagnostic methods
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- Wen-hong Zhang
Cryptococcal Meningitis
Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report
CRICS financial report for the first budget year of the study
- Trial name
- NCT02955862
- Testing
- Vietnam Cryptococcal Retention in Care Study (CRICS)
- Where
- Vietnam
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- National Hospital for Tropical Diseases, Hanoi, Vietnam
Systemic Lupus Erythematosus (SLE), Lupus Nephritis
Lupus Landmark Study: A Prospective Registry and Biorepository
The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Erythematosus (SLE), including…
- Conditions
- Systemic Lupus Erythematosus (SLE), Lupus Nephritis, Neuropsychiatric Systemic Lupus Erythematosus
- Trial name
- NCT05934149
- Where
- 25 sites in United States, Canada
- Volunteers
- 3,500 people
- Sponsor
- Lupus Research Alliance
Meningitis, Bacterial Infections
Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis
Prospective, multicenter, observational clinical registry of pediatric patients with acute infectious meningitis across approximately 20 public and private hospitals in Brazil.
- Conditions
- Meningitis, Bacterial Infections, Viral Meningitis, Fungal Meningitis
- Trial name
- ATLAS-II (NCT07062445)
- Where
- Brazil
- Volunteers
- 600 people
- Sponsor
- Hospital Israelita Albert Einstein
Diphtheria, Hepatitis B
Immunogenicity & Safety Study of a Vaccine Against Meningitis in Infants (2,4,6 Months) After a Hepatitis B Birth Dose.
The purpose of the study is to demonstrate consistent results in 3 production lots of Hib-MenAC vaccine when extemporaneously mixed with Tritanrix™-HepB and administered as a single injection, with respect to immunogenicity…
- Conditions
- Diphtheria, Hepatitis B, Haemophilus Influenzae Type b, Whole Cell Pertussis
- Trial name
- NCT00317161
- Testing
- DTPw-HBV/Hib-MenAC conjugate vaccine
- Where
- 3 sites in Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
West Nile Virus, West Nile Fever
Prospective Investigation of Oxidative Stress in West Nile Virus Infection
The investigator hypothesizes that oxidative stress responses to West Nile virus infection in the central nervous system determine the severity of infection and the long-term neurological, neuropsychological and functional…
- Conditions
- West Nile Virus, West Nile Fever, West Nile Fever Encephalitis, West Nile Fever Meningitis
- Trial name
- PROWENI (NCT04371003)
- Where
- Romania
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health