Clinical trials: Viral Pneumonia
COVID-19 (Healthy Volunteers)
Safety, Reactogenicity, and Immunogenicity Study of Heterologous Booster Vaccination of a SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510)
This is randomized, placebo-controlled, observer-blinded, multi-center study to assess safety, reactogenicity and immunogenicity of booster vaccination of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted…
- Trial name
- NCT05175950
- Testing
- SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine (GBP510) (RBD of SARS-CoV-2 25ug / dose) Adjuvanted with AS03, Normal saline
- Where
- 9 sites in South Korea
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Covid19, Thrombotic Microangiopathies
Ravulizumab and COVID-19
Ultomiris (Ravulizumab), is a monoclonal antibody that specifically targets terminal complement products and is proposed for the treatment of COVID-19 induced microvasculature injury and endothelial damage leading to thrombotic…
- Conditions
- Covid19, Thrombotic Microangiopathies, Acute Kidney Injury
- Trial name
- NCT04570397
- Testing
- Ravulizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Brigham and Women's Hospital
Depression
Assessment of Stress, Depression and Anxiety in Healthcare Caring for Patients With COVID-19
Medical personnel working in the Intensive Care Unit will be examined by means of tests. Their aim is to check how work-related stress in a potentially lethal threat affects the occurrence of depression, stress, anxiety and sleep…
- Trial name
- NCT04631497
- Testing
- test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
- Trial name
- NCT04486313
- Testing
- Nitazoxanide, Vitamin Super B-Complex
- Where
- 2 sites in United States
- Volunteers
- 935 people
- Sponsor
- Romark Laboratories L.C.
COVID-19 Drug Treatment
Ivermectin Effect on SARS-CoV-2 Replication in Patients With COVID-19
In the context of COVID-19 pandemic, a report on ivermectin suppression of SARS-CoV-2 viral replication in cell cultures has been published, and the use of this medication seems to be potentially useful for the therapy.
- Trial name
- NCT04381884
- Testing
- IVERMECTIN (IVER P®) arm will receive IVM 600 µg / kg once daily plus standard care. CONTROL arm will receive standard care.
- Where
- 3 sites in Argentina
- Volunteers
- 45 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
COVID-19
Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial
Double-blind randomized controlled clinical trial (RCT) of low-dose lenalidomide in the treatment of elderly patients (> 60 years of age) with mild to moderate clinical signs of COVID-19 disease from the Hospital Universitario of…
- Trial name
- GETAFE (NCT04361643)
- Testing
- Lenalidomide as a 5 mg capsule PO daily, days 1, 3, and 5.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitario Getafe
Covid19, SARS (Severe Acute Respiratory Syndrome)
A Phase 3 Randomized Double Blind Efficacy and Safety Study of Oral Polio Vaccine and NA-831 for Covid-19
In this randomized double blind Phase 3 clinical trial we will study the efficacy and safety of oral polio vaccine with and without NA-831 versus placebo.
- Conditions
- Covid19, SARS (Severe Acute Respiratory Syndrome), SARS-CoV Infection, SARS-CoV-2
- Trial name
- OPV-NA831 (NCT04540185)
- Testing
- Biological: oral polio vaccine, NA-831, Combination of oral polio vaccine and NA-831
- Where
- 10 sites in United States, New Zealand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Biomed Industries, Inc.
Occupational Health
Influence of the COVId-19 Pandemic on STRESS of Occupational Health Workers
Coronavirus has caused containment of more than half of the world's population and a major and rapid reorganization of clinical and support services.
- Trial name
- COVISTRESSWork (NCT04619576)
- Testing
- Occupational health workers
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
SARS-CoV2 Infection, Ventilator Associated Pneumonia
Ventilation Associated Pneumonia and Covid-19
In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation.
- Conditions
- SARS-CoV2 Infection, Ventilator Associated Pneumonia, Ards, COVID-19
- Trial name
- ECOLCOVID (NCT05089968)
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Corona Virus Infection, Pneumonia
COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused mass mortality in the last 3 months that necessitates urgent development of new therapeutical agents.
- Trial name
- NCT04389385
- Testing
- COVID-19 Specific T Cell derived exosomes (CSTC-Exo)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Activities, Mental Health Issue
Effects of the COVID-19 Health Emergency on Biopsychosocial Health
There is a critical need to determine the impact of the COVID-19 emergency on the comprehensive well-being of people as they are living through the emergency and sequelae of the emergency period.
- Conditions
- Activities, Mental Health Issue, Life Style
- Trial name
- NCT04409535
- Testing
- WHOQOL-BREF survey
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
EGD, Covid19
Aerosol Particle From EGD in Patients With and Without Head Box in COVID-19 Era
According to preexisting data, it has revealed the fundamental role that aerosols play in the transmission of the COVID-19 virus.
- Conditions
- EGD, Covid19, Aerosol Disease, Head Box
- Trial name
- NCT04981535
- Testing
- Head box during upper gastrointestinal endoscopy
- Where
- Thailand
- Volunteers
- 190 people
- Sponsor
- King Chulalongkorn Memorial Hospital
COVID-19
Echocardiographic Manifestation in Patients With Omicron Variant of COVID-19
The cardiovascular scenario associated with omicron, the new variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), remains unclear.
- Trial name
- NCT05379543
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
COVID-19
Phase Ⅰ Clinical Trial of a Candidate COVID-19 Vaccine
In this trial, a single-arm, open-label study design will be used to evaluate the safety and tolerability after vaccination with escalating doses of the investigational vaccine (Recombinant COVID-19 Vaccine (chimpanzee adenovirus…
- Trial name
- NCT05706324
- Testing
- Recombinant COVID-19 Vaccine (chimpanzee adenovirus vector) for Inhalation
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wuhan BravoVax Co., Ltd.
COVID-19, Vaccine Adverse Reaction
Adverse Events Report of Inactivated COVID-19 Vaccine
Numerous vaccination studies are conducted to protect against COVID-19 infection, and preclinical and clinical studies are still ongoing worldwide.
- Trial name
- NCT05026879
- Testing
- Inactivated COVID-19 vaccine (CoronaVac)
- Where
- Turkey (Türkiye)
- Volunteers
- 4,040 people, healthy volunteers welcome
- Sponsor
- Bozyaka Training and Research Hospital
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
CoV2 SARS Pneumonia
Predicting the Progression to Chronic Fibrosis of Lung Lesions Related to Covid-19 Infection From Chest CT Images
The main differences observed between SARSCoV-2 pneumonia and other epidemic viral pneumopathies (e.g., seasonal influenza) are the greater infectivity of SARSCoV-2, the clinical severity of the disease, particularly in young…
- Trial name
- PREDISCAN (NCT04483752)
- Testing
- CHEST CT SCAN
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Coronavirus Disease 2019
Inhaled Interferon α2b for the Treatment of Coronavirus Disease 19 (COVID-19)
The IN2COVID Study is a 2-staged phase I/II double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of AP-003 (Interferon α2b) when administered via inhalation twice daily for 10 days.
- Trial name
- IN2COVID (NCT04988217)
- Testing
- Interferon-Alpha2B
- Where
- Chile
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
COVID-19
Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial
This is a a randomized double blind placebo controlled Phase 2 trial with a 12 patient lead-in to evaluate safety, prior to full enrollment to an additional 28 patients (for a total of 40 patients) to assess efficacy of…
- Trial name
- DART (NCT04482621)
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
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