Clinical trials: Viral Respiratory Tract Infections
SARS-CoV2 Infection, COVID-19
Viral Dynamics of Omicron in Children
SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment.
- Trial name
- NCT05240183
- Testing
- Daily SARS-CoV-2 PCR Testing for 10 days
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- The Hospital for Sick Children
COVID-19
Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients
Evidence has shown that COVID-19 infections can lead to an increased risk of blood clots. These blood clots can lead to individuals being admitted to hospital, or, unfortunately in severe cases, death.
- Trial name
- ETHIC (NCT04492254)
- Testing
- Enoxaparin
- Where
- 3 sites in Australia, Belgium and 1 more
- Volunteers
- 219 people
- Sponsor
- Thrombosis Research Institute
Covid19
The Impact of Fecal Microbiota Transplantation as an Immunomodulation on the Risk Reduction of COVID-19 Disease Progression With Escalating Cytokine Storm and Inflammatory Parameters
The gut microbiota provides an intestinal biological barrier against pathogens and has a pivotal role in the maintenance of intestinal homeostasis and modulation of the host immune system.
- Trial name
- FeMToCOVID (NCT04824222)
- Testing
- Human fecal microbiota, MBiotix HBI, SOC
- Volunteers
- 366 people
- Sponsor
- Medical University of Warsaw
COVID-19
Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)
The study will evaluate the efficacy and safety of aprepitant injectable emulsion added to standard of care for hospitalized patients with COVID-19.
- Trial name
- NCT04470622
- Testing
- Aprepitant injectable emulsion
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Heron Therapeutics
COVID-19, Dysglycemia
Can Intensive Insulin Therapy Improve Outcomes of COVID-19 Patients
Evaluation of the reciprocal relation between hyperglycemia/diabetes mellitus (HG/DM) and COVID-19 disease and the effect of mode of insulin therapy; intensive (IIT) or conventional (CIT) on patients' outcomes All patients…
- Trial name
- NCT05441631
- Testing
- Insulin, Subcutaneous Insulin
- Where
- Egypt
- Volunteers
- 436 people
- Sponsor
- Benha University
COVID-19
Breath Samples Collection Clinical Trial, for Development of the TERA BioStation T101, Intended for CoV-19 Exhalation Products Detection.
The Sponsor has developed a rapid screening tool intended to determine if the subject tested has COVID-19.
- Trial name
- NCT05162495
- Testing
- BioStation T101 and TeraTube
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tera Group
Covid19
BARCONA: A Study of Effects of Bardoxolone Methyl in Participants With SARS-Corona Virus-2 (COVID-19)
This multi-center, double-blind, placebo-controlled, randomized Phase 2 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in patients hospitalized with confirmed COVID-19.
- Trial name
- NCT04494646
- Testing
- Bardoxolone Methyl
- Where
- 8 sites in United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
COVID-19
Study Design of the Diacerein in Patients With Covid-19
This is a randomized, placebo-controlled, double-blind trial pilot study. This study will include individuals over 18 years of age who have been hospitalized with a confirmed diagnosis of COVID-19 to assess whether DIACEREIN…
- Trial name
- NCT05226754
- Testing
- Diacerein
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Covid19, Post-acute Covid-19 Syndrome
Physical Training in Patients With POTS After Covid-19
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Covid19, Post-acute Covid-19 Syndrome, Postural Orthostatic Tachycardia Syndrome
- Trial name
- POTS-ReCOV (NCT05094622)
- Testing
- Physical exercise program
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Long COVID-19 Syndrome
Long COVID-19 Syndrome Lifestyle Intervention Study
Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19.
- Trial name
- NCT05836402
- Testing
- Low carbohydrate diet intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
covid19
Predictive Factors COVID-19 Patients
This is a monocentric retro-prospective observational study that will be conducted on all COVID19 positive patients hospitalized at the S. Gerardo Hospital in Monza.
- Trial name
- MI-COVID (NCT04427345)
- Testing
- Predictive factors for clinical response in patients with COVID-19.
- Where
- Italy
- Sponsor
- University of Milano Bicocca
COVID-19
Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19
This prospective randomized single Center study investigates to what extent the physical elimination of the inflammatory mediators using the CytoSorb adsorber reduces the morbidity of severely and critically ill patients with…
- Trial name
- CYTOCOV-19 (NCT04344080)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
COVID-19
Evaluation of Molecular Point-of-care Xpert® Xpress SARS-CoV-2 Detection Implementation in Resource-limited Settings
This study evaluated the diagnostic accuracy and effectiveness of POC viral load (VL) assay in improving the availability of SARS-CoV-2 detection for COVID-19 patient management in decentralised healthcare facilities of…
- Trial name
- EXPERT-CoV-2 (NCT05514886)
- Testing
- Gene Expert molecular Point-of-Care (POC) (Xpert® Xpress SARS-CoV-2/Flu/RSV test
- Where
- Tanzania
- Volunteers
- 3,429 people
- Sponsor
- National Institute for Medical Research, Tanzania
Parosmia
Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia
Chronic olfactory dysfunction, both hyposmia and parosmia, from the COVID-19 pandemic is a growing public health crisis, affecting up to 1.2 million people in the United States.
- Trial name
- Stella (NCT06055270)
- Testing
- Stellate Ganglion Block
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
COVID-19, SARS-CoV-2
Assessing Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19)
This is a prospective, randomized, double-blinded, placebo-controlled, pilot study to assess the preliminary efficacy and safety of hydroxychloroquine for the treatment of patients with lower respiratory tract SARS-CoV-2…
- Trial name
- NCT04363866
- Testing
- Hydroxychloroquine
- Where
- United States
- Sponsor
- Oregon Health and Science University
COVID-19, Pregnancy Complications
Maternal Morbidity and Mortality During the COVID-19 Pandemic
A cohort study of women who deliver at select sites on randomly selected days in 2019 and 2020, and all confirmed COVID-19 infections among pregnant or immediately postpartum women in 2020.
- Trial name
- MFMU COVID-19 (NCT04519502)
- Where
- 12 sites in United States
- Volunteers
- 25,604 people
- Sponsor
- The George Washington University Biostatistics Center
Healthy Participant
A Study to Learn How the Study Medicine Called Ibuzatrelvir is Taken up Into the Blood in Healthy Chinese Adults
A study to learn how the study medicine called Ibuzatrelvir is taken up into the blood in healthy Chinese adults.
- Trial name
- NCT07235137
- Testing
- Ibuzatrelvir
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
COVID-19
COVID-19 Huashi Baidu Formula Clinical Study
Combined with the regional and population characteristics of Asia and Africa, Huashi Baidu Granule was used to intervene in mild and moderate patients with COVID-19, evaluate its efficacy and safety, and clarify its…
- Trial name
- NCT05638672
- Testing
- Huashi Baidu Granule, Monapiravir
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
SARS-CoV-2 Infection, COVID-19
A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom
This is a study to evaluate the efficacy, immune response, and safety of a coronavirus disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in adults aged 18-84 years in the United Kingdom.
- Trial name
- NCT04583995
- Testing
- SARS-CoV-2 rS/Matrix M1-Adjuvant, Licensed seasonal influenza vaccine
- Where
- 33 sites in United Kingdom
- Volunteers
- 15,185 people, healthy volunteers welcome
- Sponsor
- Novavax
Covid19
Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes
Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index…
- Trial name
- NCT05777720
- Testing
- Filtration Fan, Safe-home pamphlet, Mid-week phone call
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Stanford University