Clinical trials: Visceral Hypersensitivity
Obesity
Egg Diet to Improve Metabolic Health and Function
The purpose of this study is to determine the effects of change in diet quality (carbohydrate restriction versus fat restriction) on body composition, fat distribution, cardiometabolic risk factors, physical function, and quality…
- Trial name
- NCT02760641
- Testing
- Egg-based diet (EBD), Carbohydrate-based diet (CBD)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Irritable Bowel Syndrome, Visceral Hypersensitivity
Gut Permeability, Sensitivity and Symptomatology
To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).
- Trial name
- GPSS (NCT02358564)
- Testing
- Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Insulin Resistance, Insulin Sensitivity
Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Obesity, Inflammation
- Trial name
- NCT04708535
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Glucose Metabolism Disorders, Obesity, Visceral
The "Metabolically-obese Normal-weight" Phenotype and Its Reversal by Calorie Restriction
The prevalence of overweight and obesity in Singapore is approximately half of that in the United States, yet the incidence of type 2 diabetes is similar, and is expected to double in the near future.
- Conditions
- Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine, Insulin Sensitivity/Resistance
- Trial name
- NCT03239782
- Testing
- Calorie restriction
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Irritable Bowel Syndrome
The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients
Serotonin, 5-hydroxytryptamin (5-HT), plays an important role in regulating the gastrointestinal functions. In this study we will modulate the serotonin system with acute tryptophan depletion (ATD) and administration of…
- Trial name
- NCT00731003
- Testing
- Oxitriptan, Acute tryptophan depletion, Amino acid drink with tryptophan
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Irritable Bowel Syndrome
Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome
Irritable bowel syndrome is a common digestive disorder worldwide. However, there is no effective treatment of irritable bowel syndrome.
- Trial name
- NCT01139736
- Testing
- VSL#3
- Where
- Hong Kong
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
IBS, Ulcerative Colitis, Active
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
Aim: More insight in pathogenesis of IBS and IBD. Samples are collected in context of an European research project.
- Conditions
- IBS, Ulcerative Colitis, Active, Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms), Healthy Controls
- Trial name
- NCT02421705
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 99,999,999 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Major Depression, Pain
Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder
Patients with major depressive disorder (MDD) commonly have many gastrointestinal complaints. Gastrointestinal pain is classified into 2 categories: visceral and somatic pain.
- Conditions
- Major Depression, Pain, Abdominal Pain
- Trial name
- NCT00209807
- Testing
- escitalopram, Reboxetine, No intervention
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Irritable Bowel Syndrome
Manipulation of Visceral Sensitivity and Immune System in IBS
Irritable bowel syndrome (IBS) is a common condition. At least 20% of the population suffer from IBS. The symptoms of abdominal pain, diarrhoea, constipation, bloating and difficulty with bowel motions are often disabling.
- Trial name
- NCT00418340
- Testing
- probiotic (bacterial/dietary supplement)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
HIV Infections, Insulin Resistance
Diet, Exercise and/or Rosiglitazone for HIV-Associated Insulin Resistance
The purpose of this study is to determine if, in men and women with excess abdominal fat and insulin resistance, people with HIV infection respond differently than people without HIV to interventions that typically improve body…
- Conditions
- HIV Infections, Insulin Resistance, Obesity
- Trial name
- NCT00264251
- Testing
- Weight loss through diet and exercise, Rosiglitazone insulin sensitizing agent
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Visceral (Hyper)Sensitivity
The Effects of Butyrate Enemas on Visceral Perception
During this double blind, placebo controlled, randomised cross over study, healthy volunteers received an enema once daily for one week containing either placebo (saline), 50mM butyrate or 100mM of butyrate.
- Trial name
- NCT00726817
- Testing
- Butyrate
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Irritable Bowel Syndrome, Visceral Hypersensitivity
Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag
BACKGROUND \& AIMS: Bowel hypersensitivity (lower threshold for discomfort in response to distention of a balloon in the rectum compared to healthy controls) is a key documented feature in Irritable Bowel Syndrome (IBS)…
- Trial name
- NCT03224494
- Testing
- Rapid Barostat Bag, IBS severity scoring system questionnaire (IBS-SSS), HAD scale questionnaire
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen's University
Fibromyalgia, Irritable Bowel Syndrome
Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain.
- Trial name
- NCT00222209
- Testing
- Experimental heat pain model
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Irritable Bowel Syndrome
Fructo-oligosaccharides and Irritable Bowel Syndrome
Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria.
- Trial name
- NCT00806104
- Testing
- Fructo-oligosaccharides, Maltodextrins
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beghin-Meiji
Irritable Bowel Syndrome
Are Sleeping Disorders Associated With Visceral Hypersensitivity in Irritable Bowel Syndrome Patients ?
Visceral hypersensitivity is frequent in IBS population up to 60% and is correlated with severity and altered quality of life. Sleeping troubles are most frequent in IBS population.
- Trial name
- S3i (NCT04168047)
- Testing
- Barostat procedure, Anxiety and Depression Evaluation, Assessment of sleep quality
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Lactose Intolerance, Irritable Bowel Syndrome
The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Lactose is a carbohydrate found in milk,and Lactase Deficiency (LD) is a condition in which the small intestine cannot digest this carbohydrate due to absent or insufficient amounts of lactase.Individuals with LD may be…
- Trial name
- NCT01286597
- Testing
- dietary restriction
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Irritable Bowel Syndrome
Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients
Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently.
- Trial name
- NCT00925223
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Menopause
Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
The purpose of this study is to determine the effect of menopause on obesity, energy balance, and insulin in postmenopausal, obese women.
- Trial name
- NCT00412269
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Rumination
Role of Vagal Tone in Rumination Syndrome
Rumination syndrome is a condition in which people repeatedly and unintentionally regurgitate undigested or partially digested food from the stomach, rechew it, and then either re-swallow it or spit it out.
- Trial name
- NCT03912636
- Testing
- Diaphragmatic breathing, Deep Slow Breathing, Normal breathing
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Healthy, Glucose Metabolism Disorders
Energy Metabolism and Acute Effects of Protein Diets in Metabolically Obese Normal Weight Individuals
Asians tend to develop type 2 diabetes (T2D) at lower body mass index (BMI) levels and younger ages compared to other populations.
- Conditions
- Healthy, Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine
- Trial name
- MONW (NCT06802341)
- Testing
- Normal protein diet, Animal protein diet, Plant based diet
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation