Clinical trials: Visual Suppression
Healthy
Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
CAR is short for cortisol awakening response. The neural mechanism of CAR effect on high-order cognition and social cognition is less known...
- Trial name
- NMCARSEHHSC (NCT02799134)
- Testing
- Dexamethasone, Vitamin C
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- qinshaozheng
Cirrhosis, Liver, Immune Suppression
S100A8/A9 and Innate Immunity in Liver Disease
This observational study evaluates the concentration of immune protein S100A8/A9 in different liver failure syndromes, its interaction with the immune system and validity as an immunotherapeutic target to improve survival in…
- Conditions
- Cirrhosis, Liver, Immune Suppression, Liver Failure, Acute on Chronic, Ascites Hepatic
- Trial name
- NCT05793983
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Obesity
Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone
Background: Supplementation with the combination of Yerba maté, guarana and damiana (YGD) has been found to slow gastric emptying by 15 to 58%, and to induce a substantial weight loss over 45 days without changes in diet.
- Trial name
- YGD (NCT02185638)
- Testing
- Appetite suppressant properties of YGD and A20-50
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Circadian Disruption
Evaluation of Circadian OS Technology on Melatonin Suppression
Primary Objective: Evaluate how the Circadian OS iPad-based light intervention suppresses melatonin. This small pilot study is designed to validate the Circadian OS technology by testing physiological response using melatonin…
- Trial name
- NCT07095270
- Testing
- Circadian OS software
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Antiretroviral Treatment Outcomes
Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression
The HIV/AIDS pandemic remains among the investigators greatest public health challenges. In the absence of an effective vaccine, focus has shifted to other prevention strategies such as pre-exposure prophylaxis.
- Trial name
- TOAST (NCT01387022)
- Testing
- Tenofovir, lamivudine and efavirenz
- Where
- South Africa
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
HIV, HIV Linkage to Care
Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama
The purpose of this study is to adapt and evaluate a combination intervention that includes: (1) a data-driven approach to directed community-based HIV testing to areas with high need, (2) Project Connect to expedite linkage to…
- Conditions
- HIV, HIV Linkage to Care, HIV Testing, HIV Treatment
- Trial name
- COAST-AL (NCT05384145)
- Testing
- COAST-AL
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Malaria
Impact of Antimalarial Treatment on Measures of T Cell Suppression/Regulation in Healthy Adults From Doneguebougou, Mali
Background: Malaria is a disease that affects many people in the country of Mali and other parts of Africa. It is caused by germs that are spread by mosquito bites.
- Trial name
- NCT02659566
- Where
- Mali
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adrenal Suppression
NeSST2: The Development of a Noninvasive Short Synacthen Test
Recently there has been concern about the effect of inhaled steroids, routinely used in the treatment of asthma, on the body's ability to produce its natural stress hormone cortisol.
- Trial name
- NeSST2 (NCT03514589)
- Testing
- nasal Tetracosactide, IV tetracosactide
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Pedophilia
Lupron Sex Offender Therapy
This study compared cognitive-behavioral psychotherapy with leuprolide acetate (LA) to cognitive-behavioral psychotherapy with saline injections for 12 months.
- Trial name
- NCT00220350
- Testing
- leuprolide acetate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Schober, Justine, M.D.
Hiv
Clinical Opportunities and Management to Exploit Biktarvy as Asynchronous Connection Key (COMEBACK)
COMEBACK is an investigator-initiated, 48-week study. The study will be conducted in 100 persons living with HIV (PLWH) who have been off ART for two or more weeks.
- Trial name
- COMEBACK (NCT04519970)
- Testing
- Case Management
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gregory Huhn
Prostate Cancer
Study to Monitor the Effects of Androgen Suppression Treatment on the Heart
Suppression of effects of androgens with male sex hormones, androgen suppression treatment (AST), has been known to reduce deaths and prolong life in advanced prostate cancer.
- Trial name
- AST (NCT01230905)
- Testing
- PET scan and ultrasound
- Where
- Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Hepatitis C Infection
Herpes Simplex Type 1 Suppression in Hepatitis C
The purpose of this study is to examine the effects of valacyclovir in patients who have chronic hepatitis C, antibodies to herpes simplex type 1 infection but do not have antibodies to herpes simplex type 2 infection.
- Trial name
- HSV1/HCV (NCT01580995)
- Testing
- Valacyclovir
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parathyroid Hormone Suppression Test With Cinacalcet
Evaluation of a Cincalcet Suppression Test
The aim of the study is to compare the results of a parathyroid hormone (PTH)suppression test using a single oral tablet of cinacalcet in two groups of subjects: 1- a group of healthy adults in whom the results of the test with…
- Trial name
- NCT01103206
- Testing
- cinacalcet, cinacalcet dose 1, cinacalcet dose 2
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Vestibular, Performance
VOR Suppression in Non-Gymnast Adults
The researchers hypothesize that there is a correlation between Vestibulo-ocular reflex (VOR) performance and innate athletic skill level.
- Trial name
- NCT03227718
- Testing
- VOR and coordination measurements
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Respiration Disorders
Validation of RespiLife for Detection of Respiratory Suppression
The purpose of this study is to evaluate the accuracy of RespiLife diagnostic technology for detection of respiratory rate and oxygen saturation in human subjects.
- Trial name
- NCT03819023
- Testing
- Respilife monitor
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bioresp Technologies, Inc.
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Delirium, Cognitive Disorders
Anesthetic Depth and Postoperative Delirium Trial - 2
Recent limited evidence suggests that anesthetic depth may influence postoperative cognitive outcomes, however, the mechanism between this association is unclear.
- Trial name
- ADAPT2 (NCT01983384)
- Testing
- Processed EEG-guided anesthetic depth
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contraception
Lower Dose Depo Provera® Contraceptive Injection
This is a randomized, partially-blinded, multi-center, parallel-group study to evaluate and compare the PD and PK of MPA after a single SC injection of either 45 mg/0.3 mL, 75 mg/0.5 mL or 105 mg/0.7 mL of Depo-Provera CI, and…
- Trial name
- NCT02732418
- Testing
- Depo-Provera CI, Depo-subQ 104
- Where
- 3 sites in Brazil, Chile and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- FHI 360
Menstrual Cycle, Healthy
The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function
The purpose of this study is to determine the safety and efficacy of a continuous combined oral contraceptive pill (CCOCP) regimen.
- Trial name
- NCT00128726
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Polycystic Ovary Syndrome, Hyperandrogenism
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low.
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
- Trial name
- NCT01428089
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia