Clinical trials: Visual Suppression
Healthy, Type 2 Diabetes
Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
This study is being done to better understand how amino acids alter the release of glucagon and insulin compared to glucose alone in health and disease.
- Conditions
- Healthy, Type 2 Diabetes, Obesity
- Trial name
- NCT05264727
- Testing
- Dextrose, Clinisol 15%
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Human Immunodeficiency Virus, HIV/AIDS
Incentives to Promote Sustained Linkage to HIV Care
This study aims to test if small incentives promote linkage to care and 6-month viral suppression among individuals recently tested for HIV at selected sites within Johannesburg, South Africa.
- Trial name
- NCT04431154
- Testing
- Provision of HIV self-screen kit with incentives and linkage promotion
- Where
- South Africa
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hot Flashes
Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy
This study will look at the effects of a soy supplement called Revival on memory, quality of life, and hot flashes in men with prostate cancer who are being treated with testosterone suppression therapy.
- Trial name
- NCT00245518
- Testing
- Isoflavone
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Myocardial Suppression
Suppression With Empagliflozin as an Alternative To High-Fat Low-Carbohydrate Diet for Myocardial F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Imaging
The overall objective of this study is to assess if the empagliflozin has the potential to substitute the high fat low carb (HFLC) diet for the preparation of cardiovascular FDG-PET studies.
- Trial name
- SWEET-HEART (NCT06350903)
- Testing
- Fast + High-fat low-carbohydrate diet, Fast + Empagliflozin
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Matthieu Pelletier-Galarneau, MD MSc
Healthy, Men
Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
This is a Phase IIa multicenter, double-blind, placebo-controlled study in healthy men to evaluate the spermatogenesis suppression after oral administration of Dimethandrolone Undecanoate (DMAU) alone or with Levonorgestrel (LNG)…
- Conditions
- Healthy, Men, Male Contraception
- Trial name
- NCT03455075
- Testing
- Dimethandrolone-Undecanoate, Levonorgestrel 0.03 MG
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Premier Research
Neonatal Hearing Loss
Otoacoustic Emission Suppression Study
The focus of this project is on a physiologic auditory response called the Medial Olivocochlear Reflex (MOCR) that assesses peripheral neural function.
- Trial name
- NCT04749524
- Testing
- Medial-Olivocochlear Reflex (MOCR) Strength Measurement
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Intelligent Hearing Systems
HIV, Mental Health
NOLA GEM: Feasibility and Acceptability of an MHealth Intervention for Violence-affected PLWH
The objective of the proposed research is to conduct formative work to develop, pilot and refine a smartphone delivered intervention for violence affected people living with HIV utilizing a novel spatial-temporal methodology…
- Conditions
- HIV, Mental Health, Substance Use
- Trial name
- NCT05784714
- Testing
- NOLA GEM
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tulane University
Suppression of Ovulation
Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol
The aim of the present study was to evaluate the ability of several doses of NOMAC in combination with E2 to inhibit ovulation and to assess changes in the gonadotropin and ovarian hormone profiles, in comparison to a control…
- Trial name
- NCT01361958
- Testing
- NOMAC
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theramex
Nicotine Exposure, Nicotine Withdrawal Suppression
The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects
This study examines the acute effects in ECIG users of the two primary vehicles in ECIG liquids, propylene glycol and vegetable glycerin.
- Trial name
- NCT02500615
- Testing
- ECIG liquid vehicles
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Contraception
Study of the Safety, and Sperm and Gonadotropin Suppression of a Contraceptive Gel in Normal Men
To determine the number of men who have suppression of sperm production when using a daily regimen of Nestorone® Gel (0, 8 or 12 mg) and Testosterone Gel applied transdermally.
- Trial name
- CCN007 (NCT00891228)
- Testing
- Testosterone, Nestorone®
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Premier Research
Pulmonary Disease, Chronic Obstructive
GSK1325756 Relative Bioavailability Study in Healthy Elderly Subjects
This 2-part study will be carried out on healthy elderly subjects to evaluate relative bioavailability of danirixin formulations.
- Trial name
- NCT03457727
- Testing
- Danirixin, Omeprazole
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Oxidative Stress, Muscle Strength
The Short Term Effects of Oceanix Supplementation on Recovery
The purpose of this study will be to examine the effects of Oceanix supplementation on isometric mid-thigh pull force kinetics and salivary immunoglobulin A (indice of immune function) following a one-week intense resistance…
- Conditions
- Oxidative Stress, Muscle Strength, Resistance Training, Muscle Damage
- Trial name
- NCT04315077
- Testing
- Oceanix®, Resistance Training
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Hormone Receptor-Positive Breast Cancer
Estradiol Levels According to Body Mass Index in Premenopausal Patients With Breast Cancer
his prospective observational study will evaluate whether body mass index (BMI) is associated with serum estradiol levels in premenopausal women with hormone receptor-positive breast cancer.
- Trial name
- SIMPEC-E2 (NCT07833501)
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- D'Or Institute for Research and Education
Ovarian Neoplasms, Ovarian Cancer
OveRcoming immunosupprEssion aNd rebAlancing the Immune reSponSe in ovAriaN CancEr Study
Ovarian cancer (OC) is one of the most lethal cancers in the world due to late-stage disease at diagnosis. Standard therapy consists of debulking surgery and chemotherapy.
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Ovarian Carcinoma, Immune Suppression
- Trial name
- RENAISSANCE (NCT06611072)
- Testing
- Bone marrow aspiration, Vena puncture, Peritoneal fluid
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gynaecologisch Oncologisch Centrum Zuid
HIV
City-Wide Implementation and Evaluation of the B-OK Bottles for HIV Treatment Adherence Support in the Philadelphia Ryan White Medical Case Management Network
The researchers will conduct a hybrid implementation-effectiveness study of a city-wide B-OK rollout led by PDPH with research and evaluation support from the University of Pennsylvania.
- Trial name
- B-OK PDPH (NCT07807137)
- Testing
- B-OK Bead Bottles
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Infertility/Sterility
Cetrorelix and Ganirelix Flexible Protocol for (IVF)
Recombinant gonadotropins are currently used for ovarian stimulation in women undergoing to IVF for infertility. Recently new flexible protocols have been introduced: the "single dose" and "multiple dose" protocol.
- Trial name
- IVF (NCT03477929)
- Testing
- Ganirelix Acetate, Cetrorelix Acetate
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Obesity, Hyperinsulinism
Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men
The purpose of this study is to explore diazoxide efficacy in treatment of obese men and assessment of maximal insulin suppression in obese men without hyperglycaemia.
- Trial name
- NCT00151684
- Testing
- Diazoxide
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Efficacy of Rilpivirine-based Regimens as Switch Therapy
Efficacy of Rilpivirine-based Regimens as Switch Therapy From Nevirapine-based Regimens in HIV-infected Patients
Background: Nevirapine (NVP)-based antiretroviral therapy (ART) remains to be used in HIV-infected patients in resource limited countries despite its compliance and adverse effect concerns.
- Trial name
- NCT03664440
- Testing
- Nevirapine, Rilpivirine
- Where
- Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Seizure
Sedline 4 Channel Electroencephalogram (EEG) Monitoring During Suppression of Unilateral Hemispheric Function (Wada Test
Masimo Sedline brain function monitors are sensors (stickers) placed on a the forehead to monitor levels of "sedation" based on a bilateral 4-channel electroencephalogram (EEG).
- Trial name
- NCT02503878
- Testing
- Masimo Sedline brain function monitors
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Obsessive Compulsive Disorder, Healthy
Inhibitory Control of the Mind : Neural Bases and Impact for Obsessive-compulsive Disorders
Mental-health conditions affect million people worldwide. The economic burden of mental illness is enormous and the economic health of both developing and developed nations will depend on controlling the staggering growth in…
- Trial name
- SUPTOC (NCT02850393)
- Testing
- Functional magnetic resonance imaging, behavioral measures, physiological measurements
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen