Clinical trials: Visually Impaired Persons
Alzheimer' s Disease
A Clinical Trial of AK152 in Healthy Volunteers and Patients With Alzheimer' s Disease
This is a randomized, double-blind phase I clinical trial to evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of AK152 in Healthy Volunteers and Patients with Alzheimer' s Disease.
- Trial name
- NCT07301502
- Testing
- AK152
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Akeso
Monkeypox
A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines
This was a dose-escalation, Phase I/II study evaluating the safety, tolerability, reactogenicity and immunogenicity of the investigational RNA-based multivalent vaccine candidate BNT166a for active immunization against monkeypox…
- Trial name
- NCT05988203
- Testing
- BNT166a
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty
Effects on Postoperative Pain of Liposomal Bupivacaine in Interscalene Blocks for Total Shoulder Arthroplasty Patients
The purpose of this trial is to compare the difference in the proportion of patients with tolerable pain scores, VAS pain scores, quality of recovery and opioid use in milligram equivalents (at 24, 48, 72, 96 and 120 hours…
- Trial name
- NCT05900427
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Johnny K. Lee
Healthy Japanese Subjects
The Effect of Oral Hyaluronic Acid (UltraHA®) on the Knee Function
This clinical trial aims to clarify the effect of UltraHA® on knee joint conditions.
- Trial name
- NCT05683327
- Testing
- UltraHA® 75 mg/capsule, UltraHA® 40 mg/capsule
- Where
- 2 sites in Japan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Orthomedico Inc.
Mental Fatigue
A Study to Evaluate Efficacy of IP on Alertness and Mental Fatigue
The current study is design to asses the effect of E-AG-01/ E-AG-02/ E-AG-03 on mental alertness as compared to placebo.
- Trial name
- ALERMEN (NCT02816827)
- Testing
- AG-01, AG-05, AG-06
- Where
- India
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Opioid Overdose, Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of CSX-1004
This is a Phase 1a, randomized, double-blind, single ascending dose study, designed to assess the safety, tolerability, and PK of a single CSX-1004 injection, administered by IV infusion across a range of doses in healthy adult…
- Trial name
- NCT06005402
- Testing
- CSX-1004
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cessation Therapeutics, Inc.
Healthy
Single Rising Oral Doses of BI 10773 in Healthy Male Volunteers
Study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 10773 administered to healthy Japanese male subjects with single rising oral doses (1, 5, 10, 25, and 100 mg).
- Trial name
- NCT02182453
- Testing
- BI 10773 - single rising dose
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Overweight, Obesity
A Study to Investigate the Effects of Zovaglutide (ZT002 Injection) on QTc Interval in Healthy Adults
This study is designed to investigate the effect of treatment with Zovaglutide (ZT002 Injection) on the corrected cardiac QT interval relative to a placebo control in healthy participants.
- Trial name
- NCT07697846
- Testing
- ZT002 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Influenza
CT18 Infant Influenza Priming Study in Vaccine Naive Infants
This study evaluates whether priming influenza naive infants, age six to 23 months, with a MF59-adjuvanted (oil in water emulsion) influenza vaccine is preferred to priming with an inactivated unadjuvanted influenza vaccine.
- Trial name
- NCT03669627
- Testing
- aTIV Primer, QIV Primer, aTIV Booster
- Where
- 4 sites in Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Canadian Immunization Research Network
Healthy, Schizotypal Personality
Exceptional Experiences (EE), Salience & Dopaminergic Neurotransmission
The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis.
- Trial name
- NCT03333369
- Testing
- 200 mg levodopa/50 mg benserazide, Dextrose
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Invasive Aspergillosis
Single Ascending Oral Dose Study of F901318
Double blind, placebo controlled, ascending single oral dose, sequential group study. Forty subjects will complete the study in 5 cohorts (Groups A to E), each group consisting of 8 subjects.
- Trial name
- NCT02394483
- Testing
- F901318 safety, F901318 tolerability, F901318 pharmacokinetics
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Healthy Volunteers
A Single and Multiple Ascending and Food Effect Study of RP7214, a DHODH Inhibitor in Healthy Adult Subjects
This is a randomized, double-blind study to evaluate the safety, tolerability and PK of single and multiple ascending oral doses of RP7214.
- Trial name
- NCT04680429
- Testing
- RP7214
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Rhizen Pharmaceuticals SA
Condylomata Acuminata (External)
Pharmacodynamics, Safety and Efficacy of Topical Omiganan in Patients With External Genital Warts
The purpose of this study is to assess the pharmacodynamics, safety and efficacy of omiganan in patients with external genital warts.
- Trial name
- NCT02849262
- Testing
- Omiganan (CLS001) topical gel, Vehicle topical gel
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maruho Co., Ltd.
Drug Safety
Ascending Single-Dose Study to Evaluate VIA-3196 in Healthy Subjects
This is a single-center, randomized, double-blind, placebo-controlled, ascending single-dose study of VIA-3196 to evaluate the Safety, Pharmacokinetics and Pharmacodynamics of VIA-3196 in Healthy Subjects.
- Trial name
- NCT01367873
- Testing
- VIA-3196
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Muscle Anabolism
Biomarkers of Muscle Anabolism (MK-0000-082)
This study will evaluate the ability of comparative proteomics to identify early biomarkers of muscle anabolism.
- Trial name
- NCT00812396
- Testing
- Comparator: low dose testosterone, Comparator: high dose testosterone
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Acute Standardized Cutaneous Wounds (Punch-biopsy Wounds)
Topical GHK-Cu Gel for Acute Skin Wound Healing
This study will evaluate whether a topical gel containing GHK-Cu (a copper(II)-peptide complex) can safely speed up healing of small, standardized skin wounds in healthy adults compared with a matching vehicle gel.
- Trial name
- CuHeal (NCT07437586)
- Testing
- GHK-Cu Gel (Copper(II)-peptide complex)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hudson Biotech
Substance Use Disorders, Methamphetamine Abuse
A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants
The purpose of this Phase 1a study is to evaluate safety, tolerability, and pharmacokinetics (PK) of single, ascending doses of CS-1103, administered by intravenous (IV) infusion in healthy participants.
- Conditions
- Substance Use Disorders, Methamphetamine Abuse, Methamphetamine Intoxication
- Trial name
- NCT06316973
- Testing
- CS-1103, Sterile Saline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Smoking
Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction
Smoking is a significant risk factor for heart, lung, and respiratory system diseases, and is particularly prevalent among young people and university students.
- Trial name
- NCT07488741
- Testing
- Chest PNF Techniques Group, Chest Mobility Exercises Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Elderly, Sleep Quality
The Effect of a Foot Bath on Sleep Quality in The Elderly
This study was carried out as a single-blind randomized controlled study to investigate the effect of a foot bath on sleep quality in the elderly.
- Conditions
- Elderly, Sleep Quality, Complementary Therapy, Chronic Disease
- Trial name
- NCT05572554
- Testing
- Foot Bath Group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hatice Demirağ, Ph.D
Healthy Subjects
Bioequivalence Study of Aripiprazole in Healthy Adult Subjects Under Fasting Condition
To evaluate and compare the relative plasma bioavailability and therefore the bioequivalence of two different immediate release products each containing Aripiprazole 10 mg, after administering a single oral dose, to healthy adult…
- Trial name
- NCT05532254
- Testing
- Aripiprazole 10 mg tablet, Abilify® 10 mg tablet
- Where
- Egypt
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
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