Clinical trials: Visually Impaired Persons
Bipolar Disorder, Panic Disorder
Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD
The specific aim of this study is to evaluate the efficacy, tolerability, and safety of quetiapine SR monotherapy and divalproex sodium ER monotherapy in comparison to placebo in the treatment of ambulatory bipolar disorder with…
- Conditions
- Bipolar Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00579280
- Testing
- quetiapine SR, divalproex sodium ER
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy Subjects
Study of TAVO101 in Healthy Volunteers
This is a Phase 1, single ascending dose study designed to investigate TAVO101, administered as an IV infusion in healthy subjects.
- Trial name
- NCT05298046
- Testing
- Experimental: TAVO101
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tavotek Biotherapeutics
Persons With Mild to Moderate Knee Osteoarthritis
Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis
Study wishes to determine if the use of injectable bee venom is a safe and effective treatment for persons with mild to moderate knee Osteoarthritis and would result in decreased report of pain and discomfort, increased function…
- Trial name
- NCT00253942
- Testing
- Injecting bee venom as a treatment for OA
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rheumatology Therapeutics Medical Center
Malaria,Falciparum
Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali
Background: Researchers are trying to develop a vaccine that will safely reduce the spread of malaria in the community by preventing mosquitos from carrying malaria from person to person.
- Trial name
- NCT05135273
- Testing
- Pfs230D1-EPA/Matrix-M Vaccine, Verorab Rabies Vaccine
- Where
- Mali
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers
AZD6088 Single Ascending Dose Study
The aims of the study are to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD6088 following single ascending dose administration in healthy male and non-fertile females.
- Trial name
- NCT00931541
- Testing
- AZD6088
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mild Cognitive Impairment (MCI), Cognitive Dysfunction, Cognitive Disorder
A Study of Sabroxy™ (Oroxylum Indicum Extract) for Improving Cognitive Function in Adults With Mild Memory Concerns
This study is testing whether Sabroxy™ (Oroxylum indicum extract) can improve memory and thinking in older adults who report mild problems with their cognition.
- Conditions
- Mild Cognitive Impairment (MCI), Cognitive Dysfunction, Cognitive Disorder, Memory Problems
- Trial name
- NCT07189754
- Testing
- Sabroxy™ (Oroxylum indicum extract)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Refractory Solid Tumors, Lymphomas
A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
This is a double-blind (vis-a-vis lenvatinib), randomized, placebo-controlled, three-treatment, three-way crossover study in healthy subjects. There are two phases in this study: Pre-Randomization and Randomization.
- Trial name
- NCT01525394
- Testing
- Lenvatinib, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Schizophrenia
Safety, Tolerability and Pharmacokinetic Study of Multiple Rising Doses of TAK- 063 in Participants With Stable Schizophrenia and Healthy Participants
The purpose of this study is to characterize the safety and tolerability of TAK-063 when administered as multiple oral doses at escalating dose levels in participants with stable schizophrenia and in healthy Japanese participants.
- Trial name
- NCT01879722
- Testing
- TAK-063
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Takeda
Anaemia
Single Dose, Pharmacokinetic, Safety, Tolerability and QTc Study of GSK1278863 in Healthy Volunteers
This study is being performed to comply with regulatory requirements that all new non-antiarrhythmic drugs must be assessed for potential effects on cardiac repolarization through electrocardiographic evaluation in a 'Thorough…
- Trial name
- NCT02293148
- Testing
- GSK1278863 75 mg, GSK1278863 500 mg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Participants
A Safety and Tolerability Study of BPR-30221616 Injection in Healthy Subjects
The purpose of this study is to determine the safety, tolerability, pharmacokinetics、 pharmacodynamics and immunogenicity of BPR-30221616 in healthy subjects.
- Trial name
- NCT06760455
- Testing
- BPR-30221616 Injection, Sodium Chloride Injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chengdu Brilliant Pharmaceutical Co., Ltd.
Corneal Defect
Evaluating the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects
The subjects of this study were patients who underwent corneal endothelial transplantation,who were randomly divided into 3 groups, 2 groups (0.002% and 0.004% ZKY001 eye drops) and 1 placebo control group.
- Trial name
- NCT04228926
- Testing
- ZKY001 eye drops 0.3g:0.006mg, ZKY001 eye drops 0.3g:0.012mg, ZKY001 simulated eye drops
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Healthy Subjects
Evaluation of the Effects of a Food Supplementation on the Improvement of Cognitive Functions in Healthy Seniors
The hypothesis of this study is to evaluate the effect of supplementation for 8 weeks on the improvement of cognitive functions in healthy seniors with or without mild cognitive decline.
- Trial name
- BioMind (NCT05472285)
- Testing
- Verum
- Where
- 2 sites in France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Perceived Alcohol Intoxication
Possible Effects of Energy Drink Ingestion on Perceived Alcohol Intoxication
The purpose of this study is to determine whether the ingestion of caffeine, Energy Drinks has an effect on perceived alcohol intoxication.
- Trial name
- NCT01350089
- Testing
- Comparator 1 (with alcohol; without caffeine and energy drink), Comparator 2 (with alcohol and caffeine; without energy drink), Comparator 3 (with alcohol and energy drink)
- Where
- Austria
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Inflammatory Diseases
Safety and Tolerability of Single and Multiple Doses of ISIS 353512 in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerability of single and multiple doses of ISIS 353512, to evaluate the blood concentration and rate elimination of ISIS 353512 from the blood, and to evaluate the…
- Trial name
- NCT00734240
- Testing
- ISIS 353512
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Tooth Bleaching, Tooth Sensitivity
Combined Bleaching Technique: Efficacy and Tooth Sensitivity
The aim of this clinical study is to evaluate the efficacy and dental sensitivity associated with Combined Bleaching Technique (in-office + at-home) varying in-office bleaching application under two different time protocols, and…
- Trial name
- NCT03089216
- Testing
- Combined Bleaching(2x20), Combined Bleaching(2x20) with arginine, Combined Bleaching (1x20)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Terezinha de Jesus Esteves Barata
Acute Gastroenteritis, Norwalk Virus Infection
Norwalk Vaccine Study
The purpose of this study was to evaluate the efficacy of the Norwalk virus-like particle (VLP) vaccine as determined by the illness rate of viral acute gastroenteritis (AGE) during the inpatient stay.
- Trial name
- NCT00973284
- Testing
- Norwalk VLP vaccine, mannitol and sucrose, Norwalk virus
- Where
- 3 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Takeda
TQT Study
A Phase 1, Single Ascending Dose, Randomized, Double-Blind, Placebo and Positive Controlled Study to Evaluate the Cardiovascular Effect of Tetrodotoxin in Healthy Adult Subjects
To determine if a single subcutaneous (SC) administration of TTX at various dose levels has an effect on the QT/QTc intervals when assessing concentration QT (C-QT) relationship (i.e., QT/QTc intervals prolongation in relation to…
- Trial name
- NCT04083833
- Testing
- Tetrodotoxin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wex Pharmaceuticals Inc.
AD
A Phase I Study of SSGJ-716 in Healthy Adults and Participants With Moderate-to-Severe Atopic Dermatitis
The purpose of this Phase 1 study is to evaluate the safety and tolerability of a new investigational drug called SSGJ-716 in healthy adults and in participants with moderate-to-severe atopic dermatitis (AD).
- Trial name
- NCT07693738
- Testing
- SSGJ-716
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Skin Graft Complications
Study to Assess the Safety and Efficacy of DERMASEAL for the Treatment of Split-Thickness Skin Graft Donor Site Wounds
The goal of this study to determine whether the combination biologic/drug DERMASEAL will safely decrease donor wound pain after split-thickness skin graft surgery.
- Trial name
- NCT06134843
- Testing
- DERMASEAL
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hobart W. Harris
Healthy
Study of Multiple Oral Doses of PF-06835919 in Healthy Adult Japanese Participants
This is a Phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of multiple oral doses of PF-06835919 in healthy adult Japanese participants.
- Trial name
- NCT04427917
- Testing
- PF-06835919
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
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