Clinical trials: Vitamin B1
Vitamin B1 Deficiency, Thiamine Deficiency
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
In Part 1, subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim. Part 2 will expand on Part 1 and subjects will be administered thiamine and thiamine with trimethoprim.
- Trial name
- NCT03746106
- Testing
- Trimethoprim, Metformin, Vitamin B1
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Heart Failure, Diabetes
Thiamine and Acute Decompensated Heart Failure: Pilot Study
Heart failure remains an increasing cause of morbidity and mortality in the United States even in the face of recent advances in the treatment of cardiovascular disease.
- Trial name
- NCT00680706
- Testing
- Thiamine
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Baystate Medical Center
Congenital Heart Disease, Thiamine Deficiency
The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease
Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of…
- Conditions
- Congenital Heart Disease, Thiamine Deficiency, Patent Ductus Arteriosus, Ventricular Septal Defect
- Trial name
- NCT06298344
- Testing
- Thiamine
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Sumatera Utara
Heart Diseases
Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs
The purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.
- Trial name
- NCT03989700
- Testing
- Thiamine Mononitrate
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Septic Shock, Critical Illness
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock
Despite recent medical advances, sepsis and septic shock remain a major cause of death. Sepsis is a syndrome with a wide array of physiologic, pathologic, and biochemical abnormalities.
- Trial name
- HYVITS (NCT03380507)
- Testing
- Triple therapy group
- Where
- Qatar
- Volunteers
- 106 people
- Sponsor
- Hamad Medical Corporation
Shock, Septic, Critically Ill
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Sepsis has been characterised as a dysregulated host response to infection. Adjunctive therapies targeting the inflammatory cascade are being increasingly explored, although to date, have failed to demonstrate consistent benefit…
- Conditions
- Shock, Septic, Critically Ill, Vasoplegic Syndrome, Sepsis
- Trial name
- VITAMINS (NCT03333278)
- Testing
- Vitamin C, Thiamine, Hydrocortisone,
- Where
- 8 sites in Australia, Brazil and 1 more
- Volunteers
- 216 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Ischemic Heart Disease
Creatine, D-Ribose, B1 Vitamin, and B6 Vitamin in Ischemic Heart Disease
Recently, researchers have paid attention to the development of new products such as supplements food and nutraceuticals for identify and develop integrative therapies to be used in cardiovascular disease.
- Trial name
- NCT03411369
- Testing
- Creatine, D-Ribose, B1 Vitamin, and B6 vitamin
- Volunteers
- 55 people
- Sponsor
- University of Pavia
Obesity, Child
Thiamin Deficiency in Obese Thai Children
This study is aimed to assess the prevalence of thiamin deficiency in obese Thai children.
- Conditions
- Obesity, Child, Thiamine Deficiency
- Trial name
- NCT02464865
- Testing
- Thiamine 1, Non-thiamine, Thiamine 2
- Where
- Thailand
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Healthy, Thiamine and Niacin Deficiency States
Natural Versus Synthetic Vitamin B Complexes in Human
In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) (Pan [Greek] = all; moles [Latin] = molecules/particles - brand name) versus synthetic vitamin B complexes to identify the bioavailability…
- Conditions
- Healthy, Thiamine and Niacin Deficiency States, Pyridoxine Deficiency, Folic Acid Deficiency Anemia, Dietary
- Trial name
- NCT03444155
- Testing
- Natural Panmol-B-Complex, Synthetic Vitamin B-Complex
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Septic Shock
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.
- Trial name
- NCT03872011
- Testing
- Vitamin C,thiamine,hydrocortisone
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Northern Jiangsu People's Hospital
Coronary Heart Disease, Coronary Artery Bypass Grafting
Thiamine Intervention and Coronary Artery Bypass Grafting
The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a…
- Trial name
- B1&CABG (NCT06326996)
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Meningitis, Bacteremia
THiamine for Recovery In Vulnerable Early-life Infections
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
- Trial name
- THRIVE (NCT07868679)
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Milton S. Hershey Medical Center
Alcoholism
High Dose Vitamin B1 to Reduce Abusive Alcohol Use
B1AS tests the hypothesis that increased vitamin B1 (thiamine) intake can repair brain systems damaged by alcohol and help people with alcohol problems control their alcohol use.
- Trial name
- B1AS (NCT00680121)
- Testing
- Benfotiamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas
Diet, Carbohydrate-restricted
B1 and Magnesium Supplements on Glucose Metabolism in Low-carb Dieters
Magnesium (Mg) and thiamine (vitamin B1) are micronutrients involved in the regulation of blood sugar level. Avoidance of wholegrains or fruits and starchy vegetables could impact on Mg and vitamin B1 intakes and status.
- Trial name
- B-Mag (NCT04651205)
- Testing
- vitamin B1 and magnesium supplements
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Necrotizing Soft Tissue Infection, Sepsis
HAT for the Treatment of Sepsis Associated With NASTI
Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.
- Trial name
- NCT05157360
- Testing
- HAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ascension Health
Sepsis, Septic Shock
Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial
In this study, we aim to determine whether the combination of Ascorbic Acid (Vitamin C), Thiamine (Vitamin B1), and Corticosteroids improves the trajectory of organ failure and reduces mortality in patients with sepsis and septic…
- Conditions
- Sepsis, Septic Shock, Metabolic Disturbance
- Trial name
- NCT03389555
- Testing
- vitamin C, vitamin B1, hydrocortisone, Normal saline
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sepsis, Thiamine Deficiency
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)
This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels…
- Trial name
- NCT05663164
- Testing
- Vitamin B
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Sumatera Utara
Huntington Disease
Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease
Evaluate the safety and tolerability of combined oral thiamine with biotin therapy in patients with Huntington´s disease in mild to moderate stages and it is intended to evaluate the biological effect of the treatment in the…
- Trial name
- HUNTIAM (NCT04478734)
- Testing
- Moderate doses of Thiamine y Biotin, High doses of Thiamine y Biotin
- Where
- 3 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Neurocognition, Child
Early Life Thiamine Study
Thiamine (vitamin B1) is an important nutrient needed for energy metabolism, brain development, and overall health. However, low thiamine intake is a concern in countries where white rice is the main staple since it contains…
- Trial name
- NCT07795996
- Testing
- Multiple micronutrient supplementation
- Where
- Cambodia
- Volunteers
- 1,972 people
- Sponsor
- Mount Saint Vincent University