Clinical trials: Vitamin K-status
Renal Insufficiency, Chronic
Underlying Causes of Low Vitamin K Status in Hemodialysis Patients
Studies have shown that patients with chronic kidney disease in hemodialysis have a low vitamin K status which is believed to be related to an increased risk of atherosclerosis and increased bleeding tendency.
- Trial name
- NCT03493087
- Testing
- Menakinon 7, Diet rich in vitamin K
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- University of Copenhagen
Vitamin K-status
Dose-finding Study for Vitamin K2 in Human Volunteers
Earlier studies have shown that high vitamin K-intake leads to improved bone and vascular health by increased carboxylation of Gla-proteins in these tissues.
- Trial name
- NCT00483431
- Testing
- MK7
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Kidney Calculi, Calcium Oxalate Kidney Stones
Evaluating the Vitamin K2 Status of Calcium-based Stone Formers
This is an observation, single site-study with one study visit during which all data and samples will be collected. Study participants will be asked to provide blood, urine, and fecal samples so that the investigators may study…
- Conditions
- Kidney Calculi, Calcium Oxalate Kidney Stones, Vitamin K 2, Human
- Trial name
- NCT05081960
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Rheumatic Heart Disease
Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status
VKA in RHD patients with MHV: our current status
- Trial name
- VKA and RHD (NCT07146282)
- Volunteers
- 165 people
- Sponsor
- Ahmed Hassan Rostom Ibrahim
Vascular Stiffness
Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status
Vitamin K is required for the activation of the inhibitor of vascular calcification: Matrix Gla Protein (MGP). In an earlier study the beneficial effect of menaquinone-7 (MK-7), a vitamin K2 form, was observed on the stiffness of…
- Trial name
- NCT02404519
- Testing
- Menaquinone-7
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bone Health, Vascular Health
Biocomparison Study
The effects of two vitamin K-forms on carboxylation of the vitamin K-dependent proteins osteocalcin and matrix-gla protein will be compared after supplementing these vitamins in a nutritional dose range.
- Trial name
- NCT01638182
- Testing
- Vitamin K1-capsules, Vitamin K2-capsules
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation and Flutter
INR Control and Atrial Fibrillation in Primary Care in Spain (PAULA)
The primary objective of this study was to determine rates of INR control of patients with nonvalvular AF daily attended in primary care in Spain. PAULA is an observational retrospective/cross-sectional and multicenter study.
- Trial name
- PAULA (NCT02273609)
- Testing
- Vitamin K antagonists (acenocoumarol or warfarin)
- Volunteers
- 1,524 people
- Sponsor
- Vivencio Barrios
Vitamin K Status
Vitamin K Supplementation Study in Healthy Volunteers (Aim 2B)
The overall purpose of this study is to determine how variation in the CYP4F2 gene modulates the synthesis of vitamin K-dependent clotting factors.
- Trial name
- NCT04450212
- Testing
- Phase I, Buccal Swab Collection for DNA Isolation, Phase II, Vitamin K (Vitacost) Supplementation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Washington
Vascular Calcification
Vitamin k1 and Its Relation to Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) represents one of the major complications associated with progressive renal impairment. Matrix Gla-protein (MGP) is a vitamin K-dependent protein that acts as a powerful inhibitor of vascular…
- Trial name
- NCT05060809
- Testing
- oral vitamin k1 (phylloquinone)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Obesity, Insulin Resistance
Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk (Vita-K 'n' Kids Study II)
Animal studies have found that vitamin K-dependent proteins matrix Gla protein and osteocalcin beneficially influence lipid and glucose metabolism, respectively.
- Conditions
- Obesity, Insulin Resistance, Obesity in Diabetes, Nutritional and Metabolic Diseases
- Trial name
- NCT02959762
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45-mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Vitamin K-status, Vascular Health
Effects of Dairy on Vitamin K-status
In this study, the beneficial effect of a nutrient enriched dairy product will be investigated on vitamin K-status. To achive this benefit, the study product contains extra vitamin K2.
- Trial name
- NCT01672099
- Testing
- nutrient enriched product, basic dairy product
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Orthostatic Hypotension
Vitamin K Status and Markers of Vascular Function in Patients With and Without Postural Hypotension
Postural hypotension is common in older people, leading to falls, decline in function, and dependence. Available treatments have limited efficacy and tolerability; novel approaches to treatment are therefore needed.
- Trial name
- VITKOH (NCT02505282)
- Testing
- Vitamin K status
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Micronutrient Status
Bioavailability of Micronutrients With a Special Focus on Vitamin K Dependent on Consumed Diet
Objectives The main objectives are: Study part II: to investigate the effect of a plant-based diet on micronutrient status compared to an average Danish diet Hypotheses Study part II: it is hypothesised that the status of some…
- Trial name
- BioMicro (NCT06921018)
- Testing
- change in diet
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Infant Vitamin K Status, Vitamin K Deficiency Bleeding
The OK Daily Study
The OK Daily Study is a multi-centred, part-randomised, part blinded, four cohort study. We are exploring daily dietary supplementation with vitamin K2, specifically menaquinone-7 (MK-7), given to breastfed infants or…
- Trial name
- NCT07620236
- Testing
- Combined MK-7 + vitamin D3 drops, Vitamin D3 Drops, MK-7 capsules
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Atrial Fibrillation, Venous Thrombosis
Safer Warfarin Treatment
The study is a national multicenter prospective observational study, including 200 patients. The main purpose of this study is to explore in more detail the influence of genetic variability (CYP enzymes and vitamin K dependent…
- Conditions
- Atrial Fibrillation, Venous Thrombosis, Pulmonary Embolism, Heart Valve Prosthesis
- Trial name
- CYKOWAR (NCT01042067)
- Testing
- Blood specimens (whole blood, serum, plasma)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital