Clinical trials: Vitreomacular Adhesion
Symptomatic Vitreomacular Adhesion
Follow-up Study to Assess Visual Function in Subset of Patients Who Have Previously Participated in the TG-MV-006 and TG-MV-007 Ocriplasmin Studies
The primary objective of this study is to assess visual function in up to 44 patients who have previously participated in either of the placebo controlled, ocriplasmin Phase III studies (TG-MV-006 or TG-MV-007).
- Trial name
- NCT01287988
- Testing
- ocriplasmin
- Where
- 2 sites in United States, Belgium
- Volunteers
- 24 people
- Sponsor
- ThromboGenics
Vitreomacular Adhesion Including Macular Hole
Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole
The purpose of this study is to evaluate the treatment of symptomatic vitreomacular adhesion / (VMT) including macular hole with ocriplasmin.
- Trial name
- OASIS (NCT01429441)
- Testing
- Ocriplasmin
- Where
- 25 sites in United States
- Volunteers
- 220 people
- Sponsor
- ThromboGenics
Vitreomacular Adhesion
Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial.
This trial will evaluate the safety and efficacy of microplasmin, administered as an intravitreal injection, in subjects with focal vitreomacular adhesion.
- Trial name
- NCT00798317
- Testing
- Ocriplasmin 125µg
- Where
- 48 sites in United States, Belgium and 5 more
- Volunteers
- 326 people
- Sponsor
- ThromboGenics
Symptomatic Focal Vitreomacular Adhesion
A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion
Evaluate the safety and efficacy of ophthalmic intravitreal injection of ALG-1001 in human subjects with symptomatic focal vitreomacular adhesion
- Trial name
- NCT02153476
- Testing
- 2.0mg of ALG-1001, Balanced Salt Solution
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Allegro Ophthalmics, LLC
Vitreomacular Traction, Vitreomacular Adhesion
Assessment of Patients Treated With JETREA® for Vitreomacular Traction
The purpose of this study is to observe the anatomical and functional outcomes of ocriplasmin (JETREA®) over a 6-month follow-up period.
- Trial name
- NCT02035748
- Testing
- Ocriplasmin
- Volunteers
- 628 people
- Sponsor
- Alcon Research
Vitreomacular Adhesion
Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial.
The objective of this trial is to evaluate the safety and efficacy of intravitreal microplasmin 125µg dose in subjects wiht focal vitreomacular adhesion.
- Trial name
- NCT00781859
- Testing
- 125 µg Ocriplasmin
- Where
- 41 sites in United States
- Volunteers
- 326 people
- Sponsor
- ThromboGenics
Focal Vitreomacular Adhesion
Safety and Efficacy Study of Microplasmin in for Non-Surgical Treatment of Focal Vitreomacular Adhesion
This study will evaluate the safety and efficacy of Microplasmin administered as an intravitreal injection, in subjects with focal vitreomacular adhesion.
- Trial name
- MIVI-8 (NCT01055535)
- Testing
- Microplasmin
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- ThromboGenics
Symptomatic Vitreomacular Adhesion
Ocriplasmin Research to Better Inform Treatment (ORBIT)
This is a multicenter, prospective, observational, Phase 4 study that will assess clinical outcomes and safety of JETREA® administered in a real-world setting for the treatment of symptomatic vitreomacular adhesion (VMA) by…
- Trial name
- ORBIT (NCT02079883)
- Where
- 110 sites in United States
- Volunteers
- 540 people
- Sponsor
- ThromboGenics
Exudative Age-Related Macular Degeneration, Focal Vitreomacular Adhesion
Safety and Efficacy Study of Intravitreal Ocriplasmin in Subjects With AMD With Focal Vitreomacular Adhesion
This study will evaluate the safety and efficacy of Ocriplasmin intravitreal injection, in subjects diagnosed with exudative AMD with focal vitreomacular adhesion.
- Trial name
- MIVI-5 (NCT00913744)
- Testing
- Ocriplasmin
- Where
- 27 sites in United States, Belgium and 4 more
- Volunteers
- 100 people
- Sponsor
- ThromboGenics
Symptomatic Vitreomacular Adhesion
A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion
The purpose of this study is to evaluate the superiority regarding vitreomacular adhesion (VMA) resolution of a single intravitreal injection of A01016 (Ocriplasmin) compared to sham-injection in subjects with symptomatic VMA.
- Trial name
- NCT01889251
- Testing
- Ocriplasmin
- Where
- Japan
- Volunteers
- 251 people
- Sponsor
- Alcon Research
Vitreoretinal Detachment, Vitreo-Retinal Adhesion
Microarchitecture of Vitreoretinal Contact
Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.
- Trial name
- NCT04802889
- Testing
- scanning electron microscopy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Neovascular Age-related Macular Degeneration
Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion
The main objective is to determine the efficacy of intravitreal administration of Ranibizumab combined with intravitreous injection of expansile gas and induction of posterior vitreous detachment on best-corrected visual acuity…
- Trial name
- NCT01291121
- Testing
- Intravitreal expansile gas and ranibizumab injection
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Vitreomacular Adhesion
Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older
The purpose of this study is to evaluate the prevalence of vitreomacular adhesion (VMA) in patients 40 years and older using Spectral Domain Optical Coherence Tomography.
- Trial name
- VAST (NCT02160340)
- Where
- 18 sites in United States
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Macular Degeneration
Study of Intravitreal Microplasmin in Relieving Vitreo-Macular Adhesion in Neovascular Age-related Macular Degeneration
The purpose of this study is to determine whether microplasmin given by intravitreal injection is effective and safe for the treatment of wet age-related macular degeneration (AMD) in patients who have focal vitreomacular…
- Trial name
- AMD (NCT00996684)
- Testing
- Microplasmin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Vitreomacular Traction, Vitreomacular Adhesion
Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion
The purpose of this study is to observe the anatomical and functional outcomes of ocriplasmin (JETREA™®) over a 6-month period.
- Trial name
- NCT02322229
- Testing
- Ocriplasmin 0.125 mg in a 0.1 mL volume
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Alcon Research
Vitreomacular Traction Syndrome
Pneumovitreolysis for Vitreomacular Traction
In this prospective, non-randomized, single-arm pilot study, conducted at the Eye Clinic of the University Hospital Split, the investigators are going to evaluate the utility of a single intravitreal injection of sulfur…
- Trial name
- NCT03945695
- Testing
- Pneumatic Vitreolysis in combination with "Drinking-Bird-Technique"
- Where
- Croatia
- Volunteers
- 12 people
- Sponsor
- University of Split, School of Medicine
Vitreomacular Attachment, Vitreomacular Traction
A Safety and Efficacy Assessment of Resolvine for Treatment of Vitreomacular Attachment
This research is studying the effect that Resolvine injection will have on patients with vitreomacular adhesion.
- Conditions
- Vitreomacular Attachment, Vitreomacular Traction, Vitreomacular Adhesion
- Trial name
- NCT01966328
- Testing
- 36% Resolvine Intravitreal Injection, 9% Resolvine Intravitreal Injection
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Jeffrey S Heier
Symptomatic Vitreomacular Adhesion (VMA)
A Retrospective Chart Review of Patients Treated With Ocriplasmin for Symptomatic VMA
The purpose of this study is to retrospectively review and further characterize anatomic and symptomatic changes over six months immediately following treatment of symptomatic vitreomacular adhesion (VMA) with JETREA®…
- Trial name
- OZONE (NCT02193945)
- Where
- 24 sites in United States
- Volunteers
- 134 people
- Sponsor
- ThromboGenics
Vitreomacular Adhesion
Intravitreal Gas for Vitreomacular Adhesion
Vitreomacular adhesion causes symptoms of blurry vision, distortion, and double vision. It is due to an abnormal separation of the vitreous gel from the surface of the retina and macula.
- Trial name
- RELEASE (NCT02001701)
- Testing
- Intravitreal Injection of sulfahexafluoride gas
- Where
- United States
- Sponsor
- Northern California Retina Vitreous Associates