Clinical trials: Vitreous Disorder
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Sarcoidosis-associated Ocular Inflammation
Diagnostic Yield of Vitreous Biopsy in Sarcoid Uveitis
The usefulness of diagnostic vitrectomy in patients with suspected sarcoidosis with posterior segment involvement (in whom a diagnosis cannot be determined by conventional methods) has not been well described.
- Trial name
- NCT00609687
- Testing
- Diagnostic Vitrectomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Vitreous Detachment
YAG Laser Vitreolysis for Floaters
Vitreous fluid, containing 95% water, fills the space behind the lens. Its gelatinous consistency is due to the presence of hyaluronic acid, mucopolysaccharide and collagen fibers.
- Trial name
- NCT03970148
- Testing
- Nd: YAG laser
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital of Split
Diabetic Retinopathy, Vitreous Hemorrhage Due to Diabetes Mellitus
Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy
In this phase IV, randomized, double-masked, sham-controlled study the investigators hope to determine the efficacy in peri-operative faricimab (Vabysmo) compared to sham in limiting complications from pars plana vitrectomy for…
- Trial name
- NCT06191094
- Testing
- Faricimab Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
Anti-inflammatory Effect of Curcumin, Homotaurine, Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy
Dosage of pro-inflammatory cytokines and soluble mediators (TNFα, IL6, IL2 and PDGF-AB) performed on 25 vitreous biopsies taken from patients with diabetic retinopathy and treated with increasing doses of curcumin (0.5uM and…
- Trial name
- NCT04378972
- Testing
- curcumin, homotaurine, vitamin D3, control
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Molise
Proliferative Diabetic Retinopathy
A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathy
The purpose of this study is to assess whether preoperative pegaptanib sodium safely improves vitreous hemorrhage prior to surgical intervention and to evaluate the stability of pre-existing tractional retinal detachment.
- Trial name
- No-Crunch01 (NCT01589718)
- Testing
- Macugen
- Where
- United States
- Sponsor
- Greater Houston Retina Research
Vitreous Disorder, Cataract
Outcome of Zeiss AT LARA EDOF Lens Implantation in Vitrectomized Eyes
To determine the surgical outcome and patient satisfaction in patients who underwent AT LARA lens implantation during or after vitrectomy at a relatively young age (around 55 years of age), mostly to treat (urgent) retinal…
- Trial name
- LARA (NCT05427526)
- Testing
- intraocular lens implantation
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Posterior Vitreous Detachment, Vitreomacular Traction
Vitreopapillary Interface and Optic Disc Morphology
The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH).
- Conditions
- Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction
- Trial name
- NCT02290795
- Testing
- OCT imaging/HRT imaging
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Vitreous Hemorrhage, Proliferative Diabetic Retinopathy
Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N)
This study is being conducted to determine if intravitreal injections of ranibizumab decrease the proportion of eyes in which vitrectomy is performed compared with saline injections in eyes presenting with vitreous hemorrhage…
- Trial name
- N (NCT00996437)
- Testing
- Ranibizumab, Saline
- Where
- 67 sites in United States
- Volunteers
- 261 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Complications
Preoperative Intravitreal Ranibizumab for Persistent Diabetic Vitreous Haemorrhage:
This study will enrol patients with diabetes who have already elected to undergo pars plana vitrectomy (eye surgery) to remove persistent vitreous haemorrhage (a complication of severe diabetic eye disease in which blood fills…
- Trial name
- NCT01030770
- Testing
- Ranibizumab, 0.9% Sodium Chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Eye Diseases, Ophthalmic Trauma
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease.
- Conditions
- Eye Diseases, Ophthalmic Trauma, Mitochondrial DNA, Age Related Macular Degeneration
- Trial name
- NCT04334499
- Testing
- Sample collection from tissue discard
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Uveitis
Grading Scale of Vitreous Haze in Patients With Uveitis Using Ultrasonography
This study is aimed at creation and validation of a vitreous haze scoring system using ultrasonography B-scan of the eye. Images will be obtained from patients with uveitis and quantification of inflammation will be done to…
- Trial name
- NCT02311192
- Testing
- Ultrasonography B-scan
- Sponsor
- University of Nebraska
Posterior Vitreous Detachment
High-frequency-ultrasound Annular Arrays for Ophthalmic Imaging
The objective of this research is to improve the care of ocular disease and disorders, in particular the changes in the eye associated with diabetes, by providing clinicians with dramatically improved ultrasonic images of the…
- Trial name
- NCT00633854
- Testing
- Ultrasound examination
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Proliferative Diabetic Retinopathy
Changes in Vitreous Temperature During Phacoemulsification
Temperature in the vitreous cavity decreases during vitrectomy, and the same effect is seen during an uneventful phaco surgery. Significant changes occur between the baseline temperature and after every step of the surgery.
- Trial name
- NCT01568242
- Testing
- Phacoemlsification
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Proliferative Diabetic Retinopathy, Vitreous Hemorrhage
Anti-VEGF vs. Prompt Vitrectomy for VH From PDR
Although vitreous hemorrhage (VH) from proliferative diabetic retinopathy (PDR) can cause acute and dramatic vision loss for patients with diabetes, there is no current, evidence-based clinical guidance as to what treatment…
- Trial name
- AB (NCT02858076)
- Testing
- 2-mg Intravitreous Aflibercept Injection, Prompt Vitrectomy Plus Panretinal Photocoagulation
- Where
- 62 sites in United States, Canada
- Volunteers
- 205 people
- Sponsor
- Jaeb Center for Health Research
Cataract, Corneal Disease
Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome
Pupillary movement during eye surgery can be a challenge for eye surgeons. Despite the risk of intraocular lens damage and malpositioning due to mechanical manipulation1, iris manipulation may lead to a significant elevation of…
- Conditions
- Cataract, Corneal Disease, Vitreous Disorder
- Trial name
- NCT06160960
- Testing
- OCT Scan, Video of pupil movement, video of toric lens
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Klinikum Klagenfurt am Wörthersee
Proliferative Vitreoretinopathy, Rhegmatogenous Retinal Detachment
Effects of 0.1% Nepafenac on Vitreous Inflammatory Biomarkers in Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy
PVR remains the major cause of surgical failure in RRD repair.1 Prompt surgical management is the standard therapy in RRD repair.
- Trial name
- NCT07162818
- Testing
- Nepafenac 0.1% eyedrops
- Where
- Indonesia
- Volunteers
- 61 people
- Sponsor
- Universitas Indonesia
Diabetic Retinopathy
A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects
The purpose of this study is to determine the safety and efficacy of Vitreosolve® in diabetic retinopathy patients.
- Trial name
- NCT00908778
- Testing
- Vitreosolve
- Where
- 5 sites in India, Mexico
- Volunteers
- 160 people
- Sponsor
- Vitreoretinal Technologies, Inc.
Vitreous Hemorrhage, Macula Hole
Performance, Safety and Efficiency Comparison Between 10,000 and 5,000 Cuts Per Minute Vitrectomy Using a 25G Cutter - A Prospective Randomized Controlled Study
As technology advances, vitrectomy cutters are smaller and cut rates have become faster. In this prospective study, the vitrectomy efficiency and safety between 5,000 cuts per minute with 10,000 cuts per minute are compared
- Conditions
- Vitreous Hemorrhage, Macula Hole, Epiretinal Membrane, Retinal Detachment
- Trial name
- NCT04859556
- Testing
- Alcon 25Gauge, 10,000 cuts per minute Ultravit cutter, Alcon 25Gauge, 5,000 cuts per minute Ultravit cutter
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong