Clinical trials: Vocal Cord Disease
Thyroid Diseases, Hypocalcemia
Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction
Total thyroidectomy for benign surgical pathologies is associated with risks related to temporary hypocalcaemia and vocal quality dysfunction.
- Conditions
- Thyroid Diseases, Hypocalcemia, Vocal Cord Dysfunction
- Trial name
- NCT04752852
- Testing
- Dexamethasone
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Pakistan
Larynx Disease
Effect of Acid Suppression With Esomeprazole on Vocal Cord Granulomas
The purpose of this research study is to measure the effects of the drug, esomeprazole 40 mg (Nexium) or placebo (inactive drug) on vocal cord granulomas.
- Trial name
- NCT00567658
- Testing
- Esomeprazole
- Where
- United States
- Sponsor
- Vanderbilt University
Vocal Cord Paralysis
Administration of Platelet-rich Fibrin to Autologous Fat Tissue in Injection Laryngoplasty for Vocal Cord Paralysis
The study tries to see the effect of using a combination of platelet-rich fibrin (PRF) and autologous fat as a filler for injection laryngoplasty procedures to treat unilateral adductor vocal cord paralysis.
- Trial name
- NCT04839276
- Testing
- Injection Laryngoplasty with Platelet-rich Fibrin and Autologous Fat, Injection Laryngoplasty with Autologous Fat
- Where
- Indonesia
- Volunteers
- 19 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Vocal Cord Paralysis, Recurrent Laryngeal Nerve Palsy
Single Dose 4-Aminopyridine for Diagnosing Recurrent Laryngeal Nerve Paralysis Continuity After Trauma
This study aims to evaluate the role of single-dose 4-aminopyridine on the diagnosis of recurrent laryngeal nerve (RLN) paralysis.
- Trial name
- NCT07832331
- Testing
- 4-Aminopyridine
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Percent of Vocal Cords (Glottic) Opening
Vocal Cord Views With the Classical Miller, Wis-Hipple and C-MAC Size 1 Blades in Young Children
The purpose of this study is to compare straight blades in obtaining best vocal cord view in children. The investigators will compare size 1 Classical Miller, size 1 Wis-Hipple, and size 1 C-MAC straight blades in young children.
- Trial name
- POGO (NCT03053583)
- Testing
- Laryngoscope blade
- Volunteers
- 96 people
- Sponsor
- State University of New York at Buffalo
Laryngospasm
Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children. To determine whether the co-administration of lidocaine blunts these reflex responses.
- Trial name
- LR6 (NCT01222169)
- Testing
- NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Thomas Erb
Intubation Complication, Vocal Cord Dysfunction
Evaluation of Laryngeal Morbidity After Orotracheal Intubation by Vocal Analysis and Laryngostroboscopy
The delicate structures of the larynx can be compromised by innumerable causes, one of these is represented by endotracheal intubation.
- Conditions
- Intubation Complication, Vocal Cord Dysfunction, Vocal Tone Disorder, Intubation;Difficult
- Trial name
- NCT03501095
- Testing
- Vocal analysis and Laryngostroboscopy
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Post-Thyroidectomy Dysphonia
Effects of Therapeutic Exercise With and Without Nerve Stimulation on Dysphonia in Post Thyroidectomy Patients
This clinical trial evaluates rehabilitation strategies for post-thyroidectomy dysphonia. Voice impairment is a frequent complication following thyroid surgery. It often occurs even without direct laryngeal nerve transection.
- Trial name
- NCT07811154
- Testing
- therapeutic exercise, therapeutic exercise + transcutaneous nerve stimulation
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Presbylarynx, Atrophy; Larynx
Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis
This study will investigate the safety and efficacy of four serial monthly vocal fold injections of platelet-rich plasma to treat dysphonia secondary to vocal fold atrophy, scar, and/or sulcus vocalis with glottal insufficiency
- Conditions
- Presbylarynx, Atrophy; Larynx, Dysphonia, Vocal Cord Atrophy
- Trial name
- NCT03749863
- Testing
- Serial PRP injections
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Vocal Cord Dysfunction, Vocal Cord Paralysis
Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure
The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation…
- Conditions
- Vocal Cord Dysfunction, Vocal Cord Paralysis, Vocal Cord Paresis, Recurrent Laryngeal Nerve Palsy
- Trial name
- NCT06406725
- Testing
- Point-of-Care Ultrasound of the Airway
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Easy of Laryngoscopy Manipulation, Vocal Cord Position or Movement
Intubating Condition After Magnesium Pre-treatment
Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released at the motor nerve terminal by decreasing the…
- Conditions
- Easy of Laryngoscopy Manipulation, Vocal Cord Position or Movement, Patient Reaction to Intubation and Cuff Inflation, Mean Arterial Pressure
- Trial name
- NCT01153256
- Testing
- magnesium sulphate, normal saline
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Bundang Hospital
Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion
Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced…
- Conditions
- Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
- Trial name
- EILO (NCT07420530)
- Testing
- Carbon Dioxide, Mechano-acoustic device
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vocal Cord Paralysis
Dynamic Laryngeal Opening for Bilateral Vocal Fold Paralysis by an Implanted Stimulator
People who had paralysis of the vocal cords are often prevented from breathing by this problem because the cords will not open, and the patients have to wear a tracheostomy (neck breathing tube) to bypass this airway obstruction.
- Trial name
- NCT00845442
- Testing
- pacemaker
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University Hospitals Cleveland Medical Center
Goiter
Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter
The aim of this three-arm randomized study was to evaluate results of different thyroid resection modes among patients with bilateral multinodular non-toxic goiter, with special emphasis put on recurrence rate and morbidity rate…
- Trial name
- NCT00946894
- Testing
- Total thyroidectomy, Dunhill operation, Bilateral subtotal thyroidectomy
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Laryngeal Neoplasms
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma
comparison results of treatment of early stage glottic cancer between two methods of surgical treatment - CO2 laser and KTP laser
- Trial name
- NCT02672904
- Testing
- CO2 laser, KTP laser
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Kaplan Medical Center
Vocal Cord Dysfunction
Symptom Scoring for Predicting Vocal Cord Dysfunction (VCD)
Dr. Russell Traister, et al, describes a symptom scoring system based on retrospective chart review to help identify subjects with VCD. Dr.
- Trial name
- NCT05114083
- Testing
- symptom assessment
- Sponsor
- Ohio State University
Unilateral Vocal Cord Paralysis
Surgery for Vocal Cord Paralysis
Unilateral vocal fold paralysis (UVFP) is caused by injury to the nerve to the affected vocal fold. The injury to the vocal fold makes the affected person's voice sound "breathy".
- Trial name
- NCT00064571
- Testing
- vocal fold medialization, vocal fold reinnervation
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Gastric Cancer, Hepatic Carcinoma
Laryngopharyngeal Injury After Endotracheal Intubation Under General Anesthesia
This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025…
- Conditions
- Gastric Cancer, Hepatic Carcinoma, Pulmonary Carcinoma, Pancreatic Carcinoma
- Trial name
- NCT07359586
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Zhejiang University
Paralysis, Unilateral, Vocal Cord
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
This is a prospective, 2-part, multi-center, open-label, non-randomized clinical trial to assess safety and effectiveness of APrevent® VOIS Implants for the treatment of patients with Unilateral Vocal Fold Paralysis (UVFP).
- Trial name
- NCT05119842
- Testing
- APrevent® VOIS-Implant
- Where
- 7 sites in United States, Austria and 1 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- APrevent Biotech GmbH
Thyroid Nodule
Comparison of the Vocal Cord Imaging Techniques After Thyroidectomy
Recurrent nerve palsy is a complication of thyroidectomy. Most surgeons want to visualize the vocal cords after tyroidectomy. The aim is to compare the direct laringoscopy, videolaringoscopy, fiberoptic laringoscopy and…
- Trial name
- NCT02410928
- Testing
- direct laringoscopy, fiberoptic nasal laringoscopy, ultrasonograph
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Diskapi Teaching and Research Hospital