Clinical trials: Vocal Cord Paralysis
Bilateral Vocal Fold Paralysis
Selective Bilateral Laryngeal Reinnervation as a Secondary Treatment in Case of Bilateral Vocal Fold Paralysis
Selective laryngeal bilateral reinnervation as a secondary treatment in patients with bilateral vocal fold paralysis, previously treated by endoscopy, without residual arytenoids ankylosis.
- Trial name
- SEQLAR (NCT02400008)
- Testing
- Surgery for bilateral laryngeal reinnervation
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Rouen
Iatrogenic Hypocalcemia, Iatrogenic Hypoparathyroidism
Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort
In the present study, the severity of recurrent laryngeal nerve injury (RLNI) and hypocalcemia (H) will be followed-up and the probable interrelation between them will be proposed considering the clinical situation of patients…
- Conditions
- Iatrogenic Hypocalcemia, Iatrogenic Hypoparathyroidism, Vocal Cord Paralysis, Vocal Cord Paresis
- Trial name
- NCT04396912
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Umraniye Education and Research Hospital
Vocal Fold Palsy, Vocal Cord Paralysis
A Histological Study Evaluating Silk Voice and Crosslinked Hyaluronic Acid
The primary study goal is to evaluate the histological characteristic of Silk Voice to evaluate the potential for Silk Voice to deliver long-term results to patients.
- Conditions
- Vocal Fold Palsy, Vocal Cord Paralysis, Vocal Cord Atrophy
- Trial name
- NCT04315415
- Testing
- Silk Voice
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sofregen Medical, Inc.
Vocal Cord Paralysis, Recurrent Laryngeal Nerve Palsy
Single Dose 4-Aminopyridine for Diagnosing Recurrent Laryngeal Nerve Paralysis Continuity After Trauma
This study aims to evaluate the role of single-dose 4-aminopyridine on the diagnosis of recurrent laryngeal nerve (RLN) paralysis.
- Trial name
- NCT07832331
- Testing
- 4-Aminopyridine
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Vocal Cord Paralysis
Dynamic Laryngeal Opening for Bilateral Vocal Fold Paralysis by an Implanted Stimulator
People who had paralysis of the vocal cords are often prevented from breathing by this problem because the cords will not open, and the patients have to wear a tracheostomy (neck breathing tube) to bypass this airway obstruction.
- Trial name
- NCT00845442
- Testing
- pacemaker
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University Hospitals Cleveland Medical Center
Presbylarynx, Aspiration
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders.
- Conditions
- Presbylarynx, Aspiration, Spasmodic Dysphonia, Globus Pharyngeus
- Trial name
- NCT06078527
- Testing
- Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Paralysis of Vocal Cords or Larynx, Bilateral Vocal Cord Paralysis
A Novel Approach for VC Lateralization, With Prolene Suture Stabilized Over Prolene Mesh
The larynx performs important functions of the aero-digestive tract, it has a vital role in the control of breathing, phonation, deglutition, and protection of the lower respiratory tract from aspiration.
- Trial name
- NCT05285423
- Testing
- Novel technique of Vocal cord Laterlization with Prolene suture.
- Where
- Pakistan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Vocal Cord Paralysis, Recurrent Laryngeal Nerve
Effect of IONM on Efficacy and Safety Using Sugammadex in Thyroid Surgery
Thyroidectomy is a frequently performed surgeon by the head and neck and endocrine surgeons. In recent years, surgical techniques and technological developments have resulted in a significant reduction in complication rates.
- Trial name
- NCT03634956
- Testing
- Group B. Sugammadex sodium-IONM
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Lütfiye Nuri Burat Government Hospital
Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis
Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery
This research studies whether a device used during surgery can help doctors better protect the nerve that moves a child's vocal cords. Damage to this nerve can affect speaking, swallowing, and sometimes breathing.
- Trial name
- NCT07604623
- Testing
- Intraoperative laryngeal nerve monitor
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Paralysis, Unilateral, Vocal Cord
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
This is a prospective, 2-part, multi-center, open-label, non-randomized clinical trial to assess safety and effectiveness of APrevent® VOIS Implants for the treatment of patients with Unilateral Vocal Fold Paralysis (UVFP).
- Trial name
- NCT05119842
- Testing
- APrevent® VOIS-Implant
- Where
- 7 sites in United States, Austria and 1 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- APrevent Biotech GmbH
Post-Thyroidectomy Dysphonia
Effects of Therapeutic Exercise With and Without Nerve Stimulation on Dysphonia in Post Thyroidectomy Patients
This clinical trial evaluates rehabilitation strategies for post-thyroidectomy dysphonia. Voice impairment is a frequent complication following thyroid surgery. It often occurs even without direct laryngeal nerve transection.
- Trial name
- NCT07811154
- Testing
- therapeutic exercise, therapeutic exercise + transcutaneous nerve stimulation
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Paralysis, Unilateral, Vocal Cord
Early Intracordal Hyaluronic Acid Injection During Spontaneous Reinnervation for Unilateral Recurrent Laryngeal Nerve Paralysis
Backgrounds: Unilateral vocal cord paralysis caused from recurrent laryngeal nerve (RLN) injury is not an unusual disease and may deteriorate patients'voice and swallowing outcomes.
- Trial name
- NCT02163772
- Testing
- Intracordal hyaluronate injection
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- Chang Gung Memorial Hospital
Laryngeal Carcinoma, Bilateral Vocal Cord Paresis
Thulium Contact Laser of Laryngotracheal Stenosis
The purpose of the study is to compare results of the treatment of tumorous and non-tumorous laryngotracheal stenosis using thulium contact laser versus carbon dioxide laser used in the past.
- Conditions
- Laryngeal Carcinoma, Bilateral Vocal Cord Paresis, Subglottic Stenosis
- Trial name
- NCT02587546
- Testing
- laryngeal carcinoma, bilateral vocal cord paralysis, subglottic stenosis
- Where
- Czechia
- Volunteers
- 31 people
- Sponsor
- University Hospital Ostrava
Laryngeal Disease, Spastic Dysphonia
Characteristics of Idiopathic Familial Voice Disorders
The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions; 1. Spasmodic dysphonia 2.
- Conditions
- Laryngeal Disease, Spastic Dysphonia, Voice Disorder
- Trial name
- NCT00001552
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Vocal Cord Paralysis Unilateral, Dysphonia
Silk Protein Microparticle-based Filler for Injection Augmentation
This study will investigate the safety and efficacy of a silk protein microparticle-based filler for vocal fold injection augmentation to treat dysphonia/dysphagia secondary to vocal fold paralysis.
- Conditions
- Vocal Cord Paralysis Unilateral, Dysphonia, Dysphagia, Oropharyngeal
- Trial name
- NCT03790956
- Testing
- Silk Microparticle Filler Injection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Southern California
Airway Obstruction, Vocal Cord Paralysis
Total Versus Partial Arytenoidectomy in Bilateral Vocal Fold Paralysis
Total arytenoidectomy is claimed to increase risk of aspiration and cause more voice loss than other operations performed for bilateral vocal fold paralysis (BVFP). However, objective evidence for such conclusion is lacking.
- Trial name
- NCT01824849
- Testing
- Total arytenoidectomy, Partial arytenoidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Vocal Cord Paralysis Unilateral
Laryngeal Reinnervation Versus Thyroplasty in Patients With Vocal Fold Weakness.
The purpose of this study is to help determine the most effective treatment for participants with Unilateral Vocal Fold Paralysis. There are currently two types of operations used to treat this condition.
- Trial name
- VOCALIST (NCT02973152)
- Testing
- Thyroplasty, Reinnervation
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Royal National Throat, Nose and Ear Hospital
Laryngeal Paralysis
Very Long Term VHI Voice Outcome After MTIS
Long term assesment of voice outcome after Montgomery Thyroplastie by performing a Survey of operated patients using the voice handicap index scale
- Trial name
- NCT02969993
- Testing
- Questionnaires
- Where
- 3 sites in Belgium, Spain
- Volunteers
- 53 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Recurrent Laryngeal Nerve Palsy, Risk Factors of Vocal Cord Palsy
Predisection Risk Factors for Vocal Cord Palsy After Total Thyroid Surgery
In patients undergoing total thyroidectomy, intraoperative nerve monitoring according to the International Standards Guideline Statement may detect nerves more susceptible to injury.
- Conditions
- Recurrent Laryngeal Nerve Palsy, Risk Factors of Vocal Cord Palsy, Neuromonitoring in Thyroid Surgery
- Trial name
- NCT04986592
- Volunteers
- 106 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Vocal Cord Paralysis, Unilateral
Injection Laryngoplasty Using Autologous Fat Enriched With Adipose Derived Regenerative Stem Cells (ADRC)
This is the first Development Safety Update Report prepared for Phase I-IIA Clinical Trial- FIBHGM-ECNC007-2010 (PHASE I / IIA CLINICAL TRIAL, UNICENTRIC, RANDOMIZED, CONTROLLED, TWO PARALLEL-GROUPS, TO EVALUATE THE SAFETY OF A…
- Trial name
- NCT02904824
- Testing
- adipose derived regenerative cells, centrifuged autologous fat
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Hospital General Universitario Gregorio Marañon