Clinical trials: Voice Tremor
Laryngeal Dystonia, Spasmodic Dysphonia
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
- Trial name
- NCT05150093
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Essential Tremor
Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation
Botulinum toxin is the common treatment of choice for patients with Essential Voice Tremor (EVT), but results are not universally beneficial to all patients.
- Trial name
- NCT02711995
- Testing
- RenuGel, Botulinum Toxin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Weill Medical College of Cornell University
Voice Disorders
Brain Mapping of Voice Control
Some voice disorders are caused by uncontrolled muscle actions that affect the larynx or voice box. The purpose of this study is to understand 1) how the brain controls voice production; 2) how changes in sensation within the…
- Trial name
- NCT00066911
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Essential Vocal Tremor, Essential Voice Tremor
Propranolol and Botulinum Toxin for Essential Vocal Tremor
Essential tremor is the most common adult-onset movement disorder, and essential voice tremor is the vocal manifestation of essential tremor.
- Conditions
- Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor
- Trial name
- NCT02111369
- Testing
- Propranolol, Botulinum Toxin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Voice Disorders
Dextromethorphan to Treat Patients With Voice Spasms
This study will examine how dextromethorphan, a drug that alters reflexes of the larynx (voice box), might change voice symptoms in people with voice disorders due to uncontrolled laryngeal muscle spasms.
- Trial name
- NCT00055549
- Testing
- Dextromethorphan, Lorazepam
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance
Effects of Transcutaneous Vagus Nerve Stimulation in Older Adults
The autonomic nervous system consists of two branches, the sympathetic and the parasympathetic, which must work in balance. Its functioning can be measured indirectly by heart rate variability, which is the time between…
- Conditions
- Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance, Transcutaneous Vagus Nerve Stimulation
- Trial name
- tVNS_older (NCT07292623)
- Testing
- Active location tVNS
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Spasmodic Dysphonia, Voice Tremor
Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor
Using a comprehensive approach of clinico-behavioral testing, neuroimaging and pharmacogenetics, the researchers will examine the clinical effects of sodium oxybate and the matched placebo on voice symptoms in spasmodic dysphonia…
- Trial name
- NCT03292458
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Kristina Simonyan
Spasmodic Dysphonia, Voice Tremor
Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response
The proposed research aims to determine brain abnormalities in patients with spasmodic dysphonia (SD) and voice tremor (VT) as the basis for characterization of central mechanisms underlying symptom improvement following the use…
- Trial name
- NCT01961297
- Testing
- Sodium oxybate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Kristina Simonyan
Speakers With Neurogenic Voice Disorders
Evaluating the Efficacy of Voice Therapy for Neurogenic Voice Disorders
The goal of this study is to evaluate the efficacy of voice therapy for neurogenic voice disorders. The main questions are: Does voice therapy improve patient-reported quality of life in speakers with neurogenic voice disorders?…
- Trial name
- NCT07474740
- Testing
- Breathy voice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
Essential Voice Tremor, Deep Brain Stimulation
Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?
Deep Brain Stimulation (DBS) is the gold standard treatment for Essential Tremor (ET). ET is a movement disorder which causes the arms, feet, fingers, head or voice to involuntarily shake.
- Conditions
- Essential Voice Tremor, Deep Brain Stimulation, Essential Tremor, Laryngeal Diseases
- Trial name
- EVT (NCT02960243)
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Laryngeal Dystonia, Unaffected Relatives of Laryngeal Dystonia Patients
Imaging Genetics of Laryngeal Dystonia
The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different…
- Conditions
- Laryngeal Dystonia, Unaffected Relatives of Laryngeal Dystonia Patients, Voice Tremor, Muscle Tension Dysphonia
- Trial name
- NCT03042975
- Testing
- MRI, Blood draw
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- Kristina Simonyan
Laryngeal Dystonia, Spasmodic Dysphonia
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05216770
- Testing
- Brain imaging, Laryngeal sensory block with topical bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Parkinson Disease
A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)
This is a web-based study that involves monitoring hallmark symptoms of Parkinson's Disease (PD), specifically dysphonia and tremor, using smartphone sensor data.
- Trial name
- NCT04288804
- Testing
- Smartphone microphone sensor, Smartphone accelerometer sensor
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Goalspal LLC
Vocal Tremor
False Vocal Fold vs EMG Guided Botox for Vocal Tremor
This is a prospective, non-randomized, two-arm comparative clinical trial evaluating outcomes of false vocal fold (FVF) botulinum toxin injections versus standard EMG-guided botulinum toxin injections in patients with essential…
- Trial name
- NCT07577310
- Testing
- False Vocal Fold (FVF) botulinum toxin injections, Electromyography (EMG)-Guided Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Laryngeal Dystonia, Spasmodic Dysphonia
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05150106
- Testing
- Clinical assessments of laryngeal function
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Essential Voice Tremor, Vocal Tremor
Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Essential voice tremor is a neurological condition that produces a regular, shaking quality in the voice. One form of drug treatment that produces some improvement in tremor of the hands is octanoic acid, which is a food additive…
- Conditions
- Essential Voice Tremor, Vocal Tremor, Voice Tremor, Essential Tremor of Voice
- Trial name
- NCT01864525
- Testing
- Octanoic acid, Inactive capsule
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Syracuse University
Parkinson Disease, Dystonia
Clinical and Physiological Studies of Tremor Syndromes
Background: Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known.
- Conditions
- Parkinson Disease, Dystonia, Essential Tremor
- Trial name
- NCT03027310
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)