Clinical trials: Volatile Organic Chemicals
Tuberculosis, Gastric Cancer
Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendly novel nano-chemo sensors that can…
- Conditions
- Tuberculosis, Gastric Cancer, Peptic Ulcer, Atrophic Gastritis
- Trial name
- Volatolome (NCT03228095)
- Testing
- VOC detection in breath and in skin headspace, Breath sampling, Upper endoscopy with biopsies
- Where
- Latvia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
The Phenomenon of the Decrease in the Electrical Resistance Within the Conducting Chambers, Making the Increase in a Conducting Property
The Target Urine VOCs Biosensor for Genitourinary Malignancy Detection
Volatile organic compounds (VOCs) have grown due to their crucial role in transitioning from invasive to noninvasive cancer diagnostic methods.
- Trial name
- NCT06211010
- Testing
- the semiconductor metal oxide sensors.
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suranaree University of Technology
COVID-19
Analysis of Volatile Organic Compounds by Electronic Noses in Hospitalised Patients for an Infection by SARS-COV-2 (COVID-19)
The study of volatile organic compounds (VOCs) detected in exhaled air is an innovative research area for respiratory diseases. This analysis can be done by the technique of electronic nose, simpler and faster, which provides an…
- Trial name
- VOC-COVID (NCT04379154)
- Testing
- Volatile Organic Compounds analysis
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Hopital Foch
Nutritional and Metabolic Diseases
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.
- Trial name
- VOCs (NCT03451994)
- Testing
- Breath test
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- Mebo Research, Inc.
Liver Diseases
Volatile Organic Compounds (VOCs) and Liver Diseases
Liver diseases such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and viral hepatitis have the potential to progress to cirrhosis and finally hepatocellular carcinoma (HCC).
- Trial name
- NCT01279356
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Maastricht University Medical Center
Asthma, Chronic Obstructive Lung Disease
The Identification of Different Lung Diseases by Analysis of Volatile Organic Compounds in Breath Samples
The investigators assume that by analysis of different volatile organic compounds in the breath, using nanotechnology, the investigators will be able to identify a unique respiratory signature of different diseases including…
- Trial name
- PHNOSE (NCT01631162)
- Testing
- Breath sample in all patients
- Where
- Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Pulmonary Arterial Hypertension, Systemic Sclerosis
Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH)
Aim: to investigate the role of inflammation and auto-immunity in pulmonary arterial hypertension by using the profile of volatile organic compounds.
- Conditions
- Pulmonary Arterial Hypertension, Systemic Sclerosis, Systemic Lupus
- Trial name
- VOC-PAH (NCT03819777)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
PDAC - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma
Patients with early pancreatic cancer often have symptoms that could also be caused by many common benign conditions, or no symptoms at all.
- Trial name
- VAPOR (NCT05727020)
- Testing
- Breath test, Collection of matched samples of breath, biofluids and pancreatic tissue
- Where
- United Kingdom
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cystic Fibrosis, Children
Prevention of CF Exacerbation in Childhood: PREVEC Study
Pulmonary exacerbations of CF are an important cause for the experienced disability of patients, respiratory symptoms, and decreases in lungfunction, which require antibiotic therapy at home or in the hospital.
- Conditions
- Cystic Fibrosis, Children, Exhaled Breath Condensate, Non-invasive Inflammatory Markers
- Trial name
- PREVEC (NCT01241890)
- Where
- 3 sites in Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University Medical Center
Acute Coronary Syndrome, Acute Aortic Syndrome
VOCs in Patients With Acute Cardiogenic Chest Pain
The goal of this observation study is to compare VOCs in cardiogenic chest pain population/health conditions, to answer：Establishment and promotion of the application system of emergency rapid detection of expiratory Volatile…
- Trial name
- NCT06277895
- Testing
- VOCs
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Lung Cancer, Circulating Tumor DNA
NSCLC Liquid Biopsies and Exhaled VOC
The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for…
- Trial name
- NCT06707519
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Electronic Cigarette
Nicotine Pharmacokinetic in Blood and Analysis of Exhaled Breath After E-cigarette Smoking.
Electronic or e-cigarettes are battery-powered devices that deliver vapor which may be inhaled in the manner tobacco is smoked. The e-liquid is usually a solution containing propylene glycol and/or vegetable glycerin, nicotine…
- Trial name
- VAPexp'Air (NCT03573154)
- Testing
- administration of the liquid 1 and then the liquid 2, administration of the liquid 2 and then the liquid 1
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Healthy
Effect of a Proprietary Dietary Supplement on Fecal Volatile Organic Compounds
The purpose of the study is to determine the effects of both an anthocyanin-rich polyphenol blend and an anthocyanin-rich polyphenol blend combined with a prebiotic blend on fecal microbiota metabolism (assessed by gas…
- Trial name
- NCT02871596
- Testing
- Flavonoids, Flavonoids+Prebiotics
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Colorectal Cancer, Polyp of Colon
Breath Analysis as an Additional Test for Colorectal Cancer Screening to Reduce the Number of Unnecessary Colonoscopies
In the past decade, the demand for colonoscopy procedures has increased significantly since the introduction of population-based colorectal cancer (CRC) screening in many western countries.
- Conditions
- Colorectal Cancer, Polyp of Colon, Colorectal Neoplasms
- Trial name
- SCREENER (NCT04357158)
- Testing
- AeonoseTM
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Radboud University Medical Center
Pilonidal Abscess, Non-healing Wound
Development of Volatile Organic Compounds (VOC) Analysis as a Potential Diagnostic for Infected and Non-Healing Wounds
The study aims to assess the feasibility of detecting volatile organic compounds (VOCs) from pilonidal wound dressings to assemble a VOC profile for the assessment of wound healing trends.
- Trial name
- AROMA (NCT05154838)
- Testing
- Drainage and packing of pilonidal abscess
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Cardiff and Vale University Health Board
Intestinal Transit
Gut Transit Effect on Enterohepatic Circulation
A study to determine the influence of changing intestinal transit time of the enterohepatic recirculation of bile acids.
- Trial name
- NCT03501498
- Testing
- Loperamide, Senna
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Volatile Organic Compounds, Microbiome
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis
- Trial name
- NCT05412758
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Liver Transplant Rejection, Kidney Transplant; Complications
VOCs in Kidney and Liver Transplants
Kidney and liver trasplants represent very challenging lifesaving and effective surgical procedures for patients with end-stage kidney and/or liver disease.
- Trial name
- NCT04514666
- Testing
- Breath analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Lung Cancer
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)
The goal of this observational study is to learn whether a urine-based test that measures volatile organic compounds (VOCs) can help detect lung cancer in people who have never smoked.
- Trial name
- NCT07871656
- Testing
- Biosensor Platform
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Thomas Jefferson University
Diabetes, Hyperglycemia
Miniaturized Breath-based Sensor for the Detection of Hypo- and Hyperglycemia
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia (Diabetic)
- Trial name
- NCT07696273
- Testing
- Sensing Device and Tedlar Bags
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University