Clinical trials: Volatile Organic Chemicals
Asthma; Eosinophilic
Evaluation of Volatile Organic Compounds in Mepolizumab Therapy
This study will recruit patients who are being prescribed Mepolizumab as part of their standard clinical care for the treatment of severe eosinophilic asthma.
- Trial name
- EVOC4M (NCT04924478)
- Testing
- Mepolizumab
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Colorectal Cancer, Colon Polyp
Volatile Organic Compounds (VOCs) Profile in Colorectal Cancer Patients and Healthy Controls.
Volatile organic compounds (VOCs) are low molecular weight (<1 kDa) compounds which represent the final products of cell metabolism.
- Trial name
- NCT04217083
- Testing
- Breath sampling
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Diabetes Mellitus
First Clinical Evaluation of a Novel Glucose Non-invasive Sensor Technology in Patients With Type 1 Diabetes
The primary aim of this clinical study is to find signal characteristics of VOCs detected by Sokru device during fasting, insulin injection and after glucose intake and to find the association with blood glucose variation in…
- Trial name
- VAARA (NCT05771090)
- Testing
- Sokru device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- DCB Research AG
Cystic Fibrosis
The Use of Breath Volatile Organic Compounds in Early Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis
This is a single-centre, prospective observational cohort study assessing the potential utility of the Owlstone Medical "Breath Biopsy" in early diagnosis of pulmonary infections in patients with cystic fibrosis (CF).
- Trial name
- NCT05944367
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Breast Cancer
Testing Spectrosense EVA System for Detection of Breast Cancer by Analyzing Volatile Organic Compounds (VOCs) in Exhaled Air
Volatile Organic Compounds (VOC) in human breath are captured and analyzed by the Spectrosense EVA system, which is combination of a gas chromatography (GC) and software algorithm.
- Trial name
- NCT01849328
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Rauscher, Gregory E., M.D. PA
Lung Transplant Rejection
Analysis of Volatile Organic Compounds in the Breath of Lung Transplant Rejection Patients Using Infrared Spectroscopy
This study will sample and analyze volatile organic compounds (VOCs) from participants considered to be at risk for developing rejection following lung transplant by using infrared spectroscopy.
- Trial name
- NCT06309628
- Testing
- Breathe sample
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Paragonix Technologies
Pulmonary Sarcoidosis
Breath Analysis in Patients With Suspected Sarcoidosis: The VOCs-IS Study
Sarcoidosis is a chronic condition which predominantly affects the lungs and lymph glands within the chest, however, may affect any organ within the body.
- Trial name
- NCT04318392
- Testing
- Breath Analysis, Pulmonary Function Tests, Blood sampling and storage for genetic analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Healthy Adults, Dietary Fiber Fermentation
The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals
The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three…
- Trial name
- FIBRE-MATCH (NCT07594600)
- Testing
- Low, High Fiber Diet, High, Low Fiber Diet
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Upper GI Bleeding
Analysis the Vocs in Upper GI Bleeding Patients
This project aims to collect the exhaled breath of patients with acute upper gastrointestinal bleeding clinically, divide them into large, small and no bleeding groups according to the results of gastroscopy, analyze the…
- Trial name
- NCT05457062
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
OESOPHAGO-GASTRIC CARCINOMA, Oesophageal Adenocarcinoma
AUGMENTED RESPONSE OF VOLATILE BIOMARKERS IN THE ASSESSMENT OF OESOPHAGOGASTRIC CANCER (AROMA2)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- OESOPHAGO-GASTRIC CARCINOMA, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma, Oesophageal Cancer Nos
- Trial name
- AROMA2 (NCT07260734)
- Testing
- Breath Test
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Oxidative Stress
Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers
High inspiratory oxygen fractions are known to induce oxidative stress and lipid peroxidation. The degrading products of oxidative stress induced lipid peroxidation are in part volatile and appear in breath where they can be…
- Trial name
- NCT02577692
- Testing
- Oxygen, Ambient
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Pneumonia, Ventilator-associated
Early Detection of Ventilator-associated Pneumonia (VAP)
The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation.
- Trial name
- cheqVAP (NCT02753608)
- Testing
- Collection of exhaled breath condensate
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Volatile Organic Compounds, Inflammatory Bowel Disease
Analysis of Volatile Organic Compounds in the Exhaled Air in Inflammatory Bowel Disease
The availability of noninvasive biomarkers for diagnosis and stratification of inflammatory bowel disease (IBD) courses is lacking.
- Trial name
- NCT03414580
- Testing
- Breath sampling for volatile organic compounds
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Keimyung University Dongsan Medical Center
Breath Tests, Human Volunteers
Breath Test for Chemicals (Volatile Organic Compounds)
Background: Some types of cancer, like cancer of the esophagus, are difficult to detect at an early stage. A possible detection method involves collecting breath samples to look for chemicals that may be signs of cancer.
- Conditions
- Breath Tests, Human Volunteers, Pilot Study
- Trial name
- NCT01437033
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Cirrhosis, Cirrhosis, Liver
Volatile Organic Compounds for the Assessment of Liver Disease
This study aims to determine whether a breath test could be used for early detection of hepatic fibrosis, cirrhosis or hepatocellular carcinoma.
- Conditions
- Cirrhosis, Cirrhosis, Liver, Fibrosis, Liver, Hepatocellular Carcinoma
- Trial name
- VOCAL (NCT04620538)
- Testing
- Breath Analysis
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Colorectal Cancer, Colorectal Polyps
The Colorectal Breath Analysis (COBRA) Study
This study aims to determine whether a breath test could be used for early detection of colorectal cancer and colorectal polyps.
- Conditions
- Colorectal Cancer, Colorectal Polyps, Colorectal Adenocarcinoma
- Trial name
- COBRA (NCT03699163)
- Testing
- Breath sample
- Where
- 8 sites in United Kingdom
- Volunteers
- 1,855 people
- Sponsor
- Imperial College London
Ovarian Cancer, Endometrial Cancer
Improved Early Diagnosis in Female Pelvic Cancer With OC Detect
The goal of this observational study is to learn if so called Volatile Organic Compounds (VOCs) in blood can be used for early diagnosis of ovarian cancer.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Breast Cancer, Lymphoma
- Trial name
- NCT06613230
- Where
- 2 sites in Sweden
- Volunteers
- 490 people
- Sponsor
- Region Skane
Malaria
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in Ethiopia
This is a diagnostic efficacy study to evaluate a set of biomarkers in human breath indicative of an acute malaria infection. The investigators plan to enroll 75 malaria patients and 175 febrile non-malaria patients in Ethiopia.
- Trial name
- NCT02793414
- Sponsor
- Menzies School of Health Research
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Identify Postoperative Delirium Using Exhaled Gas Patterns
Organic Compounds and Postoperative Delirum
This study involves collecting exhaled breath containing hundreds of volatile organic compounds (VOCs) that are present in very low quantity (parts per billion).
- Trial name
- NCT05875220
- Testing
- No intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia