Clinical trials: Volatile Organic Compounds
Breath Tests, Human Volunteers
Breath Test for Chemicals (Volatile Organic Compounds)
Background: Some types of cancer, like cancer of the esophagus, are difficult to detect at an early stage. A possible detection method involves collecting breath samples to look for chemicals that may be signs of cancer.
- Conditions
- Breath Tests, Human Volunteers, Pilot Study
- Trial name
- NCT01437033
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Anastomotic Leak
Non-invasive Detection of Anastomotic Leakage
Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with malignant tumors of the esophagus or pancreatic head.
- Trial name
- NCT03203434
- Testing
- Urinary volatile organic compound analysis
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Thyroid Neoplasm
Validation of the Diagnostic Accuracy of the Electronic Nose in the Detection of Thyroid Cancer
Patients with a suspected thyroid nodule face an invasive and patient unfriendly diagnostic work-up to determine the risk of malignancy.
- Trial name
- NCT04883294
- Testing
- Electronic Nose
- Volunteers
- 1,500 people
- Sponsor
- Maastricht University Medical Center
Invasive Pulmonary Aspergillosis, Breath Samples
VOC in Breath Samples for the Diagnosis of IPA
The diagnosis of invasive pulmonary aspergillosis (IPA) bears grave implications for the prognosis and treatment plan of the immunosuppressed patient.
- Conditions
- Invasive Pulmonary Aspergillosis, Breath Samples, Volatile Organic Compounds
- Trial name
- NCT05982912
- Testing
- breath sampling
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Ovarian Cancer, Endometrial Cancer
Improved Early Diagnosis in Female Pelvic Cancer With OC Detect
The goal of this observational study is to learn if so called Volatile Organic Compounds (VOCs) in blood can be used for early diagnosis of ovarian cancer.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Breast Cancer, Lymphoma
- Trial name
- NCT06613230
- Where
- 2 sites in Sweden
- Volunteers
- 490 people
- Sponsor
- Region Skane
Transplant; Complication, Rejection
Volatile Organic Compounds as Markers of Acute Rejection in Lung Transplant
The aim of research is to identify markers of acute rejection by VOC analysis in exhaled breath of bilateral-lung transplanted patients.
- Trial name
- VOC-TP (NCT03172091)
- Testing
- eNose (electronic nose), Spectrometry
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hopital Foch
Healthy Subjects
Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject.
The dyspnea is a common symptom in patients with many respiratory diseases particularly chronic obstructive airway diseases, but also cardiovascular pathologies, obesity, or also in the deconditioned healthy subjects.
- Trial name
- Volatopnee (NCT04418973)
- Testing
- VOCs analysis in exhaled air
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Electronic Cigarette
Nicotine Pharmacokinetic in Blood and Analysis of Exhaled Breath After E-cigarette Smoking.
Electronic or e-cigarettes are battery-powered devices that deliver vapor which may be inhaled in the manner tobacco is smoked. The e-liquid is usually a solution containing propylene glycol and/or vegetable glycerin, nicotine…
- Trial name
- VAPexp'Air (NCT03573154)
- Testing
- administration of the liquid 1 and then the liquid 2, administration of the liquid 2 and then the liquid 1
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy
Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures
The unpredictable nature of epileptic seizures places people with epilepsy under permanent psychological stress, which contributes significantly to a restriction in their quality of life.
- Trial name
- ICONE (NCT05865561)
- Testing
- VOC sampling
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Pilonidal Abscess, Non-healing Wound
Development of Volatile Organic Compounds (VOC) Analysis as a Potential Diagnostic for Infected and Non-Healing Wounds
The study aims to assess the feasibility of detecting volatile organic compounds (VOCs) from pilonidal wound dressings to assemble a VOC profile for the assessment of wound healing trends.
- Trial name
- AROMA (NCT05154838)
- Testing
- Drainage and packing of pilonidal abscess
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Cardiff and Vale University Health Board
Vapors; Inhalation, Cancer
Addressing Tetrachloroethylene Exposure in an Impacted Community
Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE).
- Conditions
- Vapors; Inhalation, Cancer, Volatile Organic Compounds
- Trial name
- NCT05819996
- Testing
- Environmental educational campaign
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Purdue University
Axial Spondyloarthritis
The Impact of Simulated Forest Immersion Therapy on Pain and Anxiety in Patients Axial Spondyloarthritis (axSpA)
The purpose of the study is to learn about the ease of using a humidified fragrant citrus forest oil, along with a virtual simulation of a forest environment (i.e., with sights and sounds of nature using a personal tablet Surface…
- Trial name
- NCT06072859
- Testing
- Humidified Forest Oils, Forest oils and audio-visual forest exposure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Colorectal Cancer, Polyp of Colon
Hybrid-sensor Breath Analysis for Colorectal Cancer Screening
The aim of this project is to promote the breath volatile marker concept for colorectal cancer (CRC) screening by advancing developing the application of a novel hybrid analyzer for the purpose.
- Trial name
- HYCOR (NCT05173077)
- Testing
- Identification of specific VOCs in CRC tissue surgery material, Secondary validation study in general CRC screening settings, Breath sampling for VOC detection
- Where
- Latvia
- Volunteers
- 3,000 people
- Sponsor
- University of Latvia
Urine VOCs From DKD and Nephrotic Syndrome Pateints
The Biosensor Using the Target Urine VOCs for Detecting DKD Diabetic Kidney Disease
Volatile organic compounds (VOCs) are easily evaporated substances produced by pathophysiologic metabolism and have been utilized in research as potential new biomarkers for differentiating various diseases, acting as the odor…
- Trial name
- VOCs in DKD (NCT07137351)
- Testing
- The Biosensor Using the Target Urine Volatile Organic Compounds
- Where
- Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Suranaree University of Technology
Liver Transplant Rejection, Kidney Transplant; Complications
VOCs in Kidney and Liver Transplants
Kidney and liver trasplants represent very challenging lifesaving and effective surgical procedures for patients with end-stage kidney and/or liver disease.
- Trial name
- NCT04514666
- Testing
- Breath analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Lung Cancer
The Contribution of Induced Glycolysis to the Exhaled Volatile Organic Compounds' (VOCs) Signature in Lung Cancer
Lung cancer is the most lethal cancer, killing ~1.3 million people worldwide every year. Early diagnosis could increase its survival by 3-4 folds.
- Trial name
- NCT01852838
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Malaria
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in Ethiopia
This is a diagnostic efficacy study to evaluate a set of biomarkers in human breath indicative of an acute malaria infection. The investigators plan to enroll 75 malaria patients and 175 febrile non-malaria patients in Ethiopia.
- Trial name
- NCT02793414
- Sponsor
- Menzies School of Health Research
Covid19
Detection of Covid-19 by Volatile Organic Compounds in Exhaled Breath
Our primary aim is to collect breath samples from COVID-19 positive patients at the time of diagnosis, during and after recovery using the same patient as his/her own control to identify VOCs specific to SARS-COV-2 viral…
- Trial name
- Covid-VOC (NCT04714333)
- Where
- 2 sites in Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Circulating Tumor Cell, Volatile Organic Chemicals
Diagnostic Power Comparison Between VOCs and CTCs
Early diagnosis of malignant tumors is pivotal for improving their prognoses. Circulating tumor cells (CTC) in peripheral blood and Volatile organic compounds (VOCs) in exhaled breath are newly developed diagnosis method.
- Conditions
- Circulating Tumor Cell, Volatile Organic Chemicals, Breast Cancer, Gastric Cancer
- Trial name
- NCT03958812
- Testing
- Circulating tumor cells, Volatile organic compounds
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Advanced Breast Cancer
Omic Technologies to Track Resistance to Palbociclib in Metastatic Breast Cancer
This is a monocentric cohort study, prospective and interventional with minimal risks and constraints for advanced breast cancer. The planned interventions are collection of biological samples at different times.
- Trial name
- OMERIC (NCT04653740)
- Testing
- specimen sample collection
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Oscar Lambret