Clinical trials: Volatile Organic Compounds, open to volunteers
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Healthy Adults, Dietary Fiber Fermentation
The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals
The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three…
- Trial name
- FIBRE-MATCH (NCT07594600)
- Testing
- Low, High Fiber Diet, High, Low Fiber Diet
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Malaria Fever
Non-invasive Malaria Diagnostic Data Collection in Ethiopia
This project supports the development of a non-invasive diagnostic tool for malaria, focusing on validating the link between VOCs (volatile organic compounds) and malaria infection using thermodynamic sensors.
- Trial name
- NCT07456969
- Where
- Ethiopia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Cancer of the Breast, Cancer of Stomach
Vocorder Device Validation in Clinical Settings - Continuous Monitoring of Individuals (Vocorder Clinical Validation-VCV)
This is performed under Vocorder project that is Co-Funded by the European Union. (Grant Agreement 101115442 VOCORDER HORIZON EIC-2022-PATHFINDERCHALLENGE-01).
- Conditions
- Cancer of the Breast, Cancer of Stomach, Colon Cancer, Lung Cancers
- Trial name
- VCV (NCT06711939)
- Where
- Greece
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- Mitera Hospital
Acute Respiratory Illness, Viral Respiratory Infection
Vocxi Breath Analyzer Study in Pediatric Respiratory Infection
This pilot study will evaluate whether the MBP® Breath Analyzer can collect measurable volatile organic compound signals from pediatric participants with acute respiratory illness and from healthy pediatric controls.
- Trial name
- NCT07902115
- Testing
- MBP® Breath Analyzer
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Malignant Pleural Mesothelioma
Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma
The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure how people respond to standard treatment for malignant pleural mesothelioma (MPM).
- Trial name
- NCT06037941
- Testing
- E-Nose testing, Research blood
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Identifying Patterns in the Breath of Individuals With Breast Cancer
Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be leveraged to facilitate breast cancer detection.
- Trial name
- NCT06512350
- Where
- 5 sites in United States, Canada
- Volunteers
- 5,175 people, healthy volunteers welcome
- Sponsor
- Breathe BioMedical Inc
Diabetes Mellitus
The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes
Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type…
- Trial name
- VOCircle (NCT05984979)
- Testing
- Standardized meal
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Ulcerative Colitis
Non-Invasive Biomarker Monitoring in UC on Biologics
Ulcerative colitis (UC) is a long-term inflammatory bowel condition. Many patients are treated with intravenous biologic drugs such as infliximab or vedolizumab.
- Trial name
- VIBRANT (NCT07920367)
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Respiratory Infections, COVID-19
Volatile Organic Compounds Analysis by GC-MS for Diagnostic of Hospitalised Patients With Respiratory Infections Using Exhaled Breath
Emerging respiratory diseases represent a global threat. Viruses such as influenza and coronaviruses have been the main drivers of pandemics over the past century.
- Conditions
- Respiratory Infections, COVID-19, Influenza Virus Infection, Legionella Pneumophila Infections
- Trial name
- VORTEX-2 (NCT07352462)
- Testing
- Volatile Organic compounds (VOC) analysis in Exhaled breath using GC-MS
- Where
- 7 sites in France
- Volunteers
- 777 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Colorectal Cancer
COlorectal BReath Analysis (COBRA2)
Colorectal cancer (CRC) is the second most common cause of cancer death in the United Kingdom, with approximately 17,000 deaths per year.
- Trial name
- NCT05844514
- Testing
- Breath test
- Where
- 5 sites in United Kingdom
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Vapors; Inhalation, Cancer
Addressing Tetrachloroethylene Exposure in an Impacted Community
Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE).
- Conditions
- Vapors; Inhalation, Cancer, Volatile Organic Compounds
- Trial name
- NCT05819996
- Testing
- Environmental educational campaign
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Purdue University
Diabetes, Hyperglycemia
Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia
- Trial name
- NCT06893341
- Testing
- The Sensing Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma (VAPOR2)
The investigators are developing a non-invasive breath test to help us detect pancreatic cancer earlier. The test detects small molecules called volatile organic compounds that are made by pancreatic cancers.
- Trial name
- NCT07243262
- Testing
- Breath test
- Where
- United Kingdom
- Volunteers
- 6,079 people
- Sponsor
- Imperial College London
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital