Clinical trials: Volume, open to volunteers
Anemia
Phenotyping Acute Non-Severe Anemia in the Emergency Department
Anemia is traditionally diagnosed and managed using circulating hemoglobin concentration ([Hb]). However, [Hb] is influenced by plasma volume and may not accurately reflect the total amount of hemoglobin available for oxygen…
- Trial name
- PHENOEMEMIA (NCT07761104)
- Testing
- Total hemoglobin mass measurement, Focused transthoracic echocardiography, Near-infrared spectroscopy
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Hospices Civils de Lyon
Placental Thickness, PLACENTA VOLUME
Placental Thickness -To-Fetal Weight Ratio as a Predictor of Adverse Pregnancy Outcome
The aim of this study is to evaluate the placental thickness-to-fetal weight ratio as a predictor of adverse pregnancy outcomes.
- Trial name
- NCT07467148
- Volunteers
- 70 people
- Sponsor
- Radia Atef Elzokm
High-volume, Metastatic, Hormone-sensitive Prostate Cancer (mHSPC)
Dalpiciclib Isethionate Tablets Combined With Abiraterone Acetate Tablets (I) and Prednisone Tablets (AA-P) Versus Placebo Combined With AA-P in Treatment of High-volume, Metastatic, Hormone-sensitive Prostate Cancer (mHSPC)
This study was to evaluate the safety and efficacy of dalcilide tablets in combination with AA-P in the treatment of subjects with high tumor burden mHSPC and to determine the second stage starting dose and progression-free…
- Trial name
- NCT06099990
- Testing
- dalpiciclib isethionate tablets; abiraterone acetate tablets; prednisone tablets
- Volunteers
- 660 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Lipedema
Manual and Self-Lymphatic Drainage Combined With Exercise in Women With Lipedema
This randomized controlled study aims to compare the effects of two physiotherapy approaches in women with lipedema. Participants will be assigned to either manual lymphatic drainage combined with supervised aerobic exercise or…
- Trial name
- LipoMOVE (NCT07803926)
- Testing
- Manual Lymphatic Drainage, Aerobic Exercise, Self-Lymphatic Drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Merve SEVINC GUNDUZ
Cervical Cancer, Squamous Cell Carcinoma of Cervix
Intra-lesional Tumor Boost for Bulky Cervical Cancer
The goal of this clinical trial is to learn if adding a radiation boost (intra-lesional boost) works to treat patients with large-sized cervical cancer. It will also learn about the safety of this treatment.
- Trial name
- INTLECTUAL (NCT07435376)
- Testing
- intra-lesional boost IMRT, High Dose Rate Brachytherapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Seoul National University Bundang Hospital
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anterior Cruciate Ligament (ACL)
Preoperative Rehabilitation for Patient With an ACL Injury
Muscle qualities are critical for the recovery after an anterior cruciate ligament (ACL) injury. Before ACL reconstruction (ALCR), resistance training aims to maintain patient strength and volume in order to optimize recovery.
- Trial name
- K-POP (NCT07411625)
- Testing
- Resistance training, Traditional exercises
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Nantes University Hospital
Obstructive Sleep Apnea
Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a…
- Trial name
- DISE-Pulm (NCT05350332)
- Testing
- Negative Pressure Ventilator, Pulmonary Function Testing (PFT), Transcutaneous Phrenic Nerve Stimulation
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Emory University
Chronic Obstructive Pulmonary Disease
Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function
The goal of this type of study: clinical trial is to evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function in Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT05775588
- Testing
- Lung volume reduction surgery with endobronchial valve implantation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Gastric Insufflation, I-gel
Gastric Insufflation Volume Using I-gel Versus Ambu AuraGain in Pediatric Patients Undergoing Elective Orthopedic Operations Under General Anesthesia
Our study aimed to compare the gastric insufflation volume between Ambu AuraGain and i-gel and its relationship with the oropharyngeal sealing pressure and the incidence of postoperative complications in generally anesthetized…
- Conditions
- Gastric Insufflation, I-gel, Ambu AuraGain, Pediatric
- Trial name
- NCT06853756
- Testing
- Ambu Auragain, I-gel
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Breast Neoplasms, Breast Cancer
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early…
- Conditions
- Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma
- Trial name
- I-SPY (NCT01042379)
- Testing
- Standard Therapy, AMG 386 with or without Trastuzumab, AMG 479 (Ganitumab) plus Metformin
- Where
- 42 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- QuantumLeap Healthcare Collaborative
Hemodynamic Changes
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
According to Guyton's model of venous return, the fluids that effectively increase cardiac output are those that, once administered, increase the vascular stressed volume, thereby increasing the mean systemic filling pressure…
- Trial name
- PSM-PVC-RITVEN (NCT07499388)
- Testing
- Fluid challenge of 500ml of crystalloid
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università Politecnica delle Marche
Dental Crowding, Gingival Recession
Evaluating the Clinical Efficacy of Collagen Scaffold (Ossix VOLUMAX) With Piezo-Surgical Decortication in Enhancing Orthodontic Treatment Outcomes: A Randomized Controlled Trial
Recent advances in orthodontic treatment have explored various materials to enhance treatment efficacy, particularly focusing on collagen scaffolds.
- Conditions
- Dental Crowding, Gingival Recession, Thin Phenotype
- Trial name
- NCT07097714
- Testing
- Piezocision with ribose cross-linked collagen matrix (Ossix® Volumax), control
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- NMSI DENTMASTER
Heart Failure With Preserved Ejection Fraction
SHort Of Pace - Heart Failure (SHOP-HF)
This study is designed as a multicenter, prospective, controlled, randomized, two-arms, cross-over, two parallel cohorts, efficacy Clinical research with CE-marked medical device .
- Trial name
- NCT06992089
- Testing
- Dual-chamber cardiac pacemaker (Essentio MRI L111 Boston Scientific®), Single-chamber cardiac pacemaker (Essentio MRI L110 Boston Scientific®)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Incentive Spirometer, Diaphragmatic Breathing
Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease
The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.
- Conditions
- Incentive Spirometer, Diaphragmatic Breathing, Gastroesophageal Reflux Disease (GERD), Breath Exercise
- Trial name
- NCT07179250
- Testing
- Volume-Oriented Incentive Spirometer, Diaphragmatic Breathing Exercise (DBE), Usual Care and Education
- Volunteers
- 51 people
- Sponsor
- Changhua Christian Hospital
Critical Illness
Nutrient Uptake During Continuous Enteral Feeding
Continuous enteral nutrition is used to feed patients in intensive care who are unable to eat normally. The goal of this observational study is to learn about the uptake of nutrients from feeding formula.
- Trial name
- NCT05628844
- Testing
- Continuous enteral feeding
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Felix Liebau
Hemodialysis Patient, Dry Weight
VEXUS and Assessment of Dry Weight of Patients on Hemodialysis
This is a prospective, single-arm study that will be conducted over a period of 24 weeks. The same maintenance HD patients will be followed sequentially in two study phases, with each patient serving as their own control.
- Trial name
- NCT07721636
- Testing
- ULTRASOUND for volume assessment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Breast Implant Complication, Breast Implant Shell Defect
Prospective Longitudinal Cohort Study of Implant Age, Pocket Plane, Incision, Surface Texture, and Volume as Predictors of Breast Implant Shell Fissure
This prospective implant-surveillance cohort will evaluate predictors of breast implant shell fissure. Women with aesthetic implants without baseline fissure or rupture will undergo annual clinical and imaging assessment for up…
- Trial name
- NCT07810257
- Testing
- Breast Implant Exposure, Structured Implant Shell Imaging
- Where
- Colombia
- Volunteers
- 3,000 people
- Sponsor
- Research Inc