Clinical trials: Volunteer
Idiopathic Pulmonary Arterial Hypertension
The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects
The purpose of this study is to Determine blood peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers.
- Trial name
- EXAP (NCT01590108)
- Testing
- (Pyr1)apelin-13, Saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Schizophrenia
A PET Study With RO5545965 in Healthy Male Volunteers
This single center, open-label study will evaluate the PK-PDE10A Enzyme Occupancy Relationship of RO5545965 after a single dose in healthy male volunteers by positron emission tomography (PET).
- Trial name
- NCT01923025
- Testing
- RO5545965
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy
A Study To Evaluate The Safety, Tolerability And Plasma Drug Levels Of PF-04447943 When Administered With Donepezil To Healthy Volunteer Subjects
The purpose of this study is to evaluate the safety and tolerability of PF-04447943, before and after multiple doses of donepezil in healthy volunteers. Evaluate the plasma drug levels of both PF-04447943 and donepezil.
- Trial name
- NCT01097876
- Testing
- PF-04447943 25 mg
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
This study is designed to evaluate the relative bioavailability (rBA) of multiple test tablet formulations of BMS-986435 compared to an equal dose of the BMS-986435 reference tablet formulation.
- Trial name
- NCT07226817
- Testing
- BMS-986435
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy
A Study to Compare the Pharmacodynamics of Canagliflozin and Dapagliflozin in Healthy Volunteers
The purpose of this study is to compare the pharmacodynamics (ie, how the drug affects the body) of canagliflozin with the pharmacodynamics of dapagliflozin.
- Trial name
- NCT01877889
- Testing
- Canagliflozin, Dapagliflozin
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag International NV
Influenza
Safety and Efficacy of Oral Colostrum Derived Anti Influenza Antibodies in Healthy Volunteers
Administration of colostrum enriched with anti-Flu antibodies may alter host's response to the flu virus.
- Trial name
- NCT01026350
- Testing
- colostrum enriched with anti flu antibodies
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Healthy
Safety, Tolerability and Pharmacokinetics of Danoprevir/r in Healthy Volunteers China
The purpose of this study is to evaluate the Pharmacokinetics of Danoprevir in single dose (100mg QD on day 1, day 4 and day 14) and Ritonavir-boosted Danoprevir (100mg QD on day 4 and day 14) in single and multiple doses (100mg…
- Trial name
- NCT03019991
- Testing
- Danoprevir, Ritonavir
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
Healthy
Study To Compare Safety and Pharmacokinetic Properties of Surfolase Capsule and HT-002-01 in Healthy Male Volunteers
Study to compare safety and pharmacokinetic properties of surfolase capsule and HT-002-01 after oral administration for one day in healthy male volunteer.
- Trial name
- NCT01723891
- Testing
- Surfolase capsule, HT-002-01
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharmaceutical Co., LTD.
Healthy Volunteers
A Combined Single and Multiple Ascending Dose Study of ASP6858 in Healthy Subjects
The purpose of this study is evaluate the safety and tolerability of single and multiple ascending oral doses of ASP6858. This study will also evaluate the pharmacokinetics (PK) of ASP6858 and its metabolites as well as the…
- Trial name
- NCT02359032
- Testing
- ASP6858
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Healthy
Impact of Butyricicoccus Pullicaecorum in Healthy Subjects
During this project the safety, tolerability and effect on gut microbiota of oral administration of Butyricicoccus pullicaecorum was investigated in healthy human volunteers by a placebo-controlled cross-over randomized study.
- Trial name
- NCT02477033
- Testing
- Butyricicoccus pullicaecorum 25-3T, Maltodextrin
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy
Evaluation of Four Different Dosing Regimens of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers
This is a study to determine the effect of four different dosing regimens of CLP in normal healthy volunteers.
- Trial name
- NCT02079233
- Testing
- Cross-Linked Polyelectrolyte (CLP)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sorbent Therapeutics
Gut Inflammation, Overweight and Obese Volunteers
Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.
Inflammatory bowel disease (IBD) affects over 6.8 million people worldwide, with current treatments often causing side effects and poor patient compliance.
- Trial name
- NCT07253155
- Testing
- Probiotic Arm
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy
Mechanism of Dipyridamole Action in Platelets: in Vivo Study With Healthy Volunteers
Investigation of the mechanism of dipyridamole action in platelets in an in-vivo study with healthy volunteers treated Aggrenox in comparison with volunteers treated with Persantin Retard or Acetylsalicylic Acid using platelet…
- Trial name
- NCT02226926
- Testing
- Aggrenox, Persantin Retard, Acetylsalicylic acid
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Malaria,Falciparum
Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants
This four-cohort, first-in-human, healthy participant study aims to assess the test medicine's safety and tolerability, including injection site reactions and how it is taken up by the body when given as a single dose.
- Trial name
- NCT06558643
- Testing
- MMV371 LAI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Celiac Disease
Study of ALV003 in Healthy Adult Volunteers and Subjects With Well-Controlled Celiac Disease Following a Gluten-Containing Meal
ALV003-0812 is a study of the safety and tolerability of a study drug (ALV003) in healthy adult volunteers and in patients with well-controlled celiac disease, following a meal that contains gluten.
- Trial name
- FED (NCT00669825)
- Testing
- ALV003
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Alvine Pharmaceuticals Inc.
Healthy Volunteers
A Study of Evacetrapib (LY2484595) and Warfarin in Healthy Participants
All study participants will receive both warfarin and a study drug called evacetrapib. The main purpose of this study is to look at how much warfarin gets into the blood stream and how long it takes the body to get rid of…
- Trial name
- NCT01825876
- Testing
- Evacetrapib, Warfarin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Volunteers
Limitation of the Ventilatory Response to Exercise in the Master Athlete
It is generally accepted that the ventilatory system is not a limiting factor in physical exercise in terms of performance or exercise tolerance in healthy subjects.
- Trial name
- LAHMESS (NCT05307276)
- Testing
- Heliox, Air
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy
Pharmacokinetics and Pharmacodynamics of BIWH 3 in Healthy Duffy Positive vs. Duffy Negative Male Volunteers
Study to compare the pharmacokinetic and pharmacodynamic effects of escalating dosages of recombinant human pyro-Glu MCP-1 (BIWH 3) in Duffy positive vs.
- Trial name
- NCT02249117
- Testing
- BIWH 3
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus
Comparison of PK After Administration of HCP1201 and Co-administration of Metformin SR 750mg and Rosuvastatin 10mg
To compare the pharmacokinetic characteristics between HCP1201 tablet 750/10 mg and co-administration of metformin 750 mg plus rosuvastatin 10 mg under fed state condition.
- Trial name
- NCT02026817
- Testing
- HCP1201 750/10mg, Metformin SR 750mg, Rosuvastatin 10mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Healthy Volunteers
Relative Bioavailability of BI 1467335 Tablet and Oral Solution, and Food Effect on Tablet in Healthy Male Subjects
The primary objective of this trial is to investigate the relative bioavailability of BI 1467335, given as film-coated tablet compared to BI 1467335, given as oral solution.
- Trial name
- NCT02999191
- Testing
- BI 1467335 (Treatment A), BI 1467335 (Treatment B), BI 1467335 (Treatment C)
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
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