Clinical trials: Vulnerable Populations
Hypertension
Effect of Peer Mentoring and Blood Pressure Self-monitoring on Hypertension Control.
Cardiovascular diseases are increasing throughout the developing world and are the cause of almost 16.7 million deaths each year, of which 80% occur in low and middle-income countries.
- Trial name
- NCT03297229
- Testing
- Peer mentoring, Self-monitoring
- Where
- 10 sites in Argentina
- Volunteers
- 442 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Global Mental Health
Improving Mental Health in Vulnerable Populations Through Micro-Interventions and Social Prescribing: A Factorial Randomized Trial
This full factorial trial is part of the RECONNECTED project (www.reconnected-project.eu). RECONNECTED involves a consortium of 11 European partners responding to global societal developments affecting mental wellbeing of…
- Trial name
- ReconnectedTRI (NCT07697807)
- Testing
- Moodbuster mobile application
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with…
- Trial name
- NCT07786467
- Testing
- Osteopathic Manipulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lake Erie College of Osteopathic Medicine
Heart Failure
BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups
This would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the Virtual Coach Program in elderly patients with heart failure.
- Trial name
- NCT03877328
- Testing
- BiotechCoachForAll
- Where
- 2 sites in Greece
- Volunteers
- 13 people
- Sponsor
- Aristotle University Of Thessaloniki
COVID-19
Using a Community-level Just-in-Time Adaptive Intervention to Address COVID-19 Testing Disparities
In collaboration with community partners, this study will identify disparities and dynamics of COVID-19 testing and infections in three Texas regions; and implement a multilevel intervention that increases access to testing and…
- Trial name
- NCT05606003
- Testing
- Multi-Level Multi-Component Intervention (MLI), Community Just-In-Time Adaptive Intervention (Community JITAI)
- Where
- 3 sites in United States
- Volunteers
- 1,280 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
The proposed study will use a randomized clinical trial design with non-equivalent control group and longitudinal design to evaluate the feasibility, acceptability, and preliminary effects of the Diabetes LIVE JustICE…
- Trial name
- LIVE JustICE (NCT05286892)
- Testing
- Diabetes LIVE JustICE, Enhanced Education
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Louise Reagan
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Apnea
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 2 (NCT06687655)
- Testing
- Ketone-IQ
- Where
- United States
- Sponsor
- Johns Hopkins University
Aging, Veterans
Geri Pride: Feasibility Pilot of a Group Intervention for Older Veterans
There are over one million Veterans who identify as lesbian, gay, bisexual, (LGB) or a related identity. Older LGB Veterans face unique hurdles as they age, including stress, anxiety, heart disease, cancer, decreased ability to…
- Conditions
- Aging, Veterans, Social Determinants of Health, Health Disparate Minority and Vulnerable Populations
- Trial name
- NCT07831759
- Testing
- Geri Pride Health Promotion Group
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus
Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior
This randomized controlled trial tests how digital health monitoring with financial incentives (DFI) and community health worker (CHW) support may affect how a person manages their diabetes.
- Trial name
- NCT03939793
- Testing
- IMPaCT Community Health Worker, Digital health monitoring with financial incentives, Usual Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Pregnancy
Effect of a Dairy Product for Pregnant and Lactating Women on the Composition of Human Milk
Vulnerable populations, who have deficient diets, may produce human milk (HML) that is not adequate in all nutrients, and this will have consequences on the growth and development of the child.
- Trial name
- NCT07173881
- Testing
- Fortified powder milk
- Where
- 2 sites in Argentina
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Acute Appendicitis
Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations
The overall project goal is to conduct a pilot randomized clinical trial of operative (laparoscopic appendectomy) vs nonoperative (antibiotic) management of uncomplicated acute appendicitis for vulnerable populations.
- Trial name
- NCT05724628
- Testing
- Laparoscopic appendectomy, Antibiotics (IV transitioned to oral)
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Myeloma, Cancer
Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma
This research study is investigating the safety and effectiveness of using combination of isatuximab, lenalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma (MM).
- Trial name
- NCT05145400
- Testing
- Isatuximab, Lenalidomide, Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diabetes
Addressing Social Determinants of Health & Diabetes Self-Management in Vulnerable Populations
In this pilot and feasibility study, the investigator will randomize 100 African-American, Hispanic, and/or Medicaid (all race/ethnicities) patients from KPNW with A1C ≥ 8 to one of two 6-month interventions: 1) patient…
- Trial name
- NCT03802825
- Testing
- Diabetes Self-Management Training, Standard Patient Navigation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Moderate and High Cardiovascular Risk
Effectiveness of Financial Incentives and Text Messages to Improve Health Care in Population With Moderate and High Cardiovascular Risk
Cardiovascular diseases are increasing throughout the developing world and are the cause of almost 16.7 million deaths each year, of which 80% occur in low and middle-income countries.
- Trial name
- NCT03300154
- Testing
- Financial incentives, Framing (SMS)
- Where
- 9 sites in Argentina
- Volunteers
- 917 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Linkage to Care, Homelessness
Improving Linkage to Health and Other Services for Veterans Leaving Incarceration
Veterans leaving incarceration and re-entering their communities (often described as "reentry" Veterans) face a number of challenges, including uncertainty about housing, vulnerability to substance use and relapse, on-going…
- Conditions
- Linkage to Care, Homelessness, Substance Use Disorder, Mental Health
- Trial name
- PIE (NCT02964897)
- Testing
- Peer-support plus usual care from the Health Care for Reentry Veterans program, Usual care from the Health Care for Reentry Veterans program
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- VA Office of Research and Development
Chronic Disease
Analysis of the Efficiency of a Chronic Disease Self-Management Programme in a Vulnerable Population in Five European Countries
According to the World Health Organization (WHO), it is estimated that around 35% of women and 29% of men are affected by chronic conditions and this percentage is clearly influenced by specific risk factors, such as lifestyle…
- Trial name
- EFFICHRONIC (NCT03840447)
- Testing
- Chronic Disease Self-Management programme
- Where
- France
- Volunteers
- 235 people
- Sponsor
- University Hospital, Montpellier
RZV Vaccine (Shingrix ®)
Comprehensive Characterization of Immune Response Induced by Adjuvanted Glycoprotein E (gE)-Based Recombinant VAccine Zoster in Vulnerable Population Receiving ImmunOmodulaNt Therapies
Varicella-zoster virus (VZV) is one of the eight herpesviruses that infect humans by manifesting as varicella. After primary infection VZV remains latent for life.
- Trial name
- NCT07534007
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Disaster, Vulnerable Populations
Nurses Taking On Readiness Measures - Mercer County, New Jersey
Nurses Taking On Readiness Measures (N-TORM) is an innovative nurse-driven household emergency preparedness (HEP) intervention modeled after an existing community intervention provided by emergency management personnel.
- Trial name
- NTORM (NCT05455580)
- Testing
- Nurses Taking On Readiness Measures (N-TORM)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Metabolic Syndrome
Effect of High Cheese Consumption on Metabolic Syndrome Risk Factors
The overall aim of the present research project is to examine whether consumption of high daily amounts of cheese, both high-fat and low-fat, affects risk markers of disease in a study population of men and women with metabolic…
- Trial name
- Osterix (NCT02616471)
- Testing
- High-fat cheese, Low-fat cheese, No-cheese/carbohydrate
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
HIV Infection
Integrated Care Centers to Improve HIV Outcomes in Vulnerable Indian Populations
This is a cluster randomized trial to evaluate the effectiveness of integrated care centers (ICC) to improve access to HIV testing, prevention services, and treatment among high-risk populations of injection drug users (IDU) and…
- Trial name
- NCT01686750
- Testing
- Integrated care centers
- Where
- India
- Volunteers
- 21,726 people
- Sponsor
- Johns Hopkins University