Clinical trials: Vulnerable Populations
Covid19
COVID-19 Citizen Science Expansion Project
COVID-19 Citizen Science (CCS), launched in March 2020, supports collaborative research on symptoms, risk factors, surveillance, biomarkers and testing for COVID-19 using the Eureka Research Platform.
- Trial name
- NCT05548803
- Where
- 9 sites in United States
- Volunteers
- 52,351 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV, Adherence
Evaluation of a Computer-Based System Using Cell Phones for HIV People in Peru
The investigators propose to develop and evaluate a computer-based intervention using cell phones to enhance adherence to antiretroviral treatment (ART) and support of HIV transmission risk-reduction among adult HIV-positive…
- Conditions
- HIV, Adherence, Sexual Behavior, HIV Infections
- Trial name
- Cell-POS (NCT01118767)
- Testing
- Cell phone intervention
- Where
- 2 sites in Peru
- Volunteers
- 210 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Behavioral Health
Caring for the Whole Person
The goal of this study is to identify outcomes associated with Behavioral Health Integration (BHI) that matter to patients, to compare changes in outcome over time to measure the impact of different BHI models on different…
- Trial name
- NCT03034369
- Testing
- Access to Care, Depression Screening, Patient-Provider Relationship
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Providence Health & Services
Hypertension
Effect of Peer Mentoring and Blood Pressure Self-monitoring on Hypertension Control.
Cardiovascular diseases are increasing throughout the developing world and are the cause of almost 16.7 million deaths each year, of which 80% occur in low and middle-income countries.
- Trial name
- NCT03297229
- Testing
- Peer mentoring, Self-monitoring
- Where
- 10 sites in Argentina
- Volunteers
- 442 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Overweight or Obesity, Obesity, Abdominal
Hypocaloric Mediterranean Diet or Physical Activity to Lower Cardiometabolic Risk
The purpose of this randomized controlled trial is to test the effects of a hypocaloric Mediterranean diet or of physical activity in participants who take at least 2 antihypertensive drugs but do not reach blood pressure…
- Conditions
- Overweight or Obesity, Obesity, Abdominal, Hypertension
- Trial name
- MeDiPA (NCT04155112)
- Testing
- Physical activity, Hypocaloric Mediterranean diet
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Head and Neck Neoplasms
Customized Registry Tool for Tracking Adherence to Clinical Guidelines for Head and Neck Cancers
To implement and evaluate a health information technology platform designed to support the management of patients with head and neck cancer in an urban, publicly-funded outpatient setting.
- Trial name
- NCT03546322
- Testing
- Registry
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- University of California, San Francisco
HIV, Illicit Drug User
STRIBILD in Non-Nucleoside Resistant Patients (SINNR STUDY)
The SINNR study will evaluate the virologic efficacy (viral load <50 copies/mL)and safety of STRIBILD administered for 48 weeks to HIV-infected current or recent illicit drug users.
- Trial name
- SINNR (NCT02306577)
- Testing
- STRIBILD
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Infectious Diseases Centre
Loneliness, Depression
A Pilot Study to Examine the Impact of a Therapy Dog Intervention on Loneliness and Related Health Outcomes in Vulnerable Populations
The purpose of this research study is to test whether an animal-assisted interaction (AAI) intervention is better than conversation with another person or treatment as usual for improving mood, anxiety, loneliness, quality of…
- Conditions
- Loneliness, Depression, Anxiety, Quality of Life
- Trial name
- NCT05089201
- Testing
- Animal-assisted interaction, Conversational control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Virginia Commonwealth University
Treatment Adherence
Pilot Study of a Transition Intervention for ALWH
The investigators will conduct a pilot study of a community-based intervention designed to improve outcomes among adolescents living with HIV (ALWH) transitioning to adult HIV care in Lima, Peru.
- Trial name
- PASEO (NCT05022706)
- Testing
- Community-based accompaniment and home visits, Directly Observed Therapy, Monthly Peer Support Groups
- Where
- 3 sites in Peru
- Volunteers
- 30 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Health Services Research, Prisons, Delivery of Health Care, Vulnerable Populations, Community Health Aides
Evaluation of Transitions Clinic: A Post-Release Clinic for Recently Released Parolees With Chronic Medical Conditions
The purpose of this study is to study the effectiveness of the Transitions Clinic, a post-release clinic for parolees with chronic medical conditions, in achieving increased primary care engagement, lower rates of inappropriate…
- Trial name
- NCT01179035
- Testing
- Transitions Clinic - parolee-targeted care, Expedited Primary Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Transitions Clinic
Pregnancy
Effect of a Dairy Product for Pregnant and Lactating Women on the Composition of Human Milk
Vulnerable populations, who have deficient diets, may produce human milk (HML) that is not adequate in all nutrients, and this will have consequences on the growth and development of the child.
- Trial name
- NCT07173881
- Testing
- Fortified powder milk
- Where
- 2 sites in Argentina
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri
Fracture, Influenza Vaccination
Influenza Vaccination Against Infectious Complications and Mortality in Older Adults With Fractures: a Large-scale Retrospective Cohort Study
Background: Both influenza and bone fractures are significant contributors to morbidity and mortality among older adults. This study evaluated the associations between influenza vaccination (IV) and adverse outcomes following…
- Trial name
- NCT07231016
- Where
- Taiwan
- Volunteers
- 561,566 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Hospital
Multiple Myeloma, Relapse
Isa-Pom-Dex in Elderly/Frail Subjects With RRMM
This research study aims to evaluate the safety and effectiveness of the combination of isatuximab, pomalidomide, and dexamethasone (Isa-Pd) for the treatment of relapsed or refractory multiple myeloma (RRMM), which refers to…
- Conditions
- Multiple Myeloma, Relapse, Refractory, Aging
- Trial name
- NCT05911321
- Testing
- Isatuximab, Pomalidomide, Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Covid19
Community Network-driven COVID-19 Testing and Vaccination of Vulnerable Populations in the Central US
This C3 project, Community network-driven COVID-19 testing of vulnerable populations in the Central US, will implement and evaluate a COVID-19 testing and vaccination approach that combines an evidence-based Social Network…
- Trial name
- C3 (NCT04743908)
- Testing
- Social Network Strategy + COVID-19 messaging
- Where
- United States
- Volunteers
- 1,328 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Frequent Users of the Emergency Department, Vulnerable Populations
Case Management for Frequent Users of the Emergency Department
The purpose of this study is to evaluate a specific case management intervention for frequent users (FU) of Emergency Department (ED).
- Trial name
- NCT01934322
- Testing
- Case Management
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Lausanne
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV Medication Adherence in Underserved Populations
The purpose of this study is to determine whether cognitive rehabilitation or psychoeducation impacts medication adherence in HIV-1 seropositive individuals.
- Trial name
- NCT02392884
- Testing
- Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Disease
Improving Advance Care Planning by Preparing Diverse Seniors for Decision Making
The objective of this proposal is to test whether a multi-media website (www.prepareforyourcare.org) that is focused on preparing older adults for communication and medical decision making can help people engage in advance care…
- Trial name
- PREPARE (NCT01990235)
- Testing
- PREPARE Intervention
- Where
- United States
- Volunteers
- 541 people
- Sponsor
- University of California, San Francisco
HIV
Using MOST to Optimize an HIV Care Continuum Intervention for Vulnerable Populations
The present study targets the large population of persons living with HIV/AIDS (PLHA) in the U.S. who are both insufficiently engaged in HIV primary care and not taking antiretroviral therapy (ART), who are mainly African…
- Trial name
- HTH2-MOST (NCT02801747)
- Testing
- Heart to Heart2 (HTH2)
- Where
- United States
- Volunteers
- 512 people
- Sponsor
- New York University
Internet-Based Intervention
Evaluation of the First Pathways Game on Parent-child Interactions and Development for Vulnerable Children
Children's brains develop quickly in the first three years of life and are particularly sensitive to their environment. Adverse experiences, such as exposure to abuse and neglect, can increase children's risk for behavioral…
- Trial name
- NCT04902404
- Testing
- First Pathways Game
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary