Clinical trials: Vulva Disease
Paget Disease of the Vulva, Paget Disease, Extramammary
PAGETEX® Photodynamic Therapy Device for the Treatment of Extra Mammary Paget's Disease of the Vulva (EMPV).
Vulvar Paget's disease is a rare skin tumour which affect Caucasian post-menopausal women. The disease is revealed by erythematous, eczematous, pruritus and vulvar burns.
- Trial name
- PAGETEX (NCT03713203)
- Testing
- pagetex PDT
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Vulva Cancer, Vulva Neoplasm
Danish Vulva Cancer Recurrence Study
The overall aim is to investigate different aspects of recurrence detection in women with vulva cancer (VC) to identify optimal treatment- and surveillance programs.
- Conditions
- Vulva Cancer, Vulva Neoplasm, Vulvar Cancer, Vulva Disease
- Trial name
- DaVulvaRec (NCT06495554)
- Testing
- Measurement of circulating tumor-DNA, Collection of patient-reported outcomes, Algorithmically determined telephone interview with a nurse
- Where
- 2 sites in Denmark
- Volunteers
- 1,295 people
- Sponsor
- University of Aarhus
Rectovaginal Fistula, Crohn Disease
Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease
Approximately 10% of all female Crohn's patients have a rectovaginal fistula. Rectovaginal fistulas cause air, stool, and/or drainage per vagina and may be associated with pain, recurrent urinary tract infections and diminished…
- Conditions
- Rectovaginal Fistula, Crohn Disease, Crohn Disease of Vulva, Rectolabial; Fistula
- Trial name
- RVF (NCT04519697)
- Testing
- Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anthony Lembo
Vulvar Self-Examination, Health Knowledge,Practices,Attitudes
Different Education Methods and Self Vulvar Examination (SVE)
The goal of this clinical trial is to increase students' awareness about Self-Vulvar Examination (SVE), and to evaluate the effect of a peer education module and an educational brochure on students' knowledge and behaviors…
- Conditions
- Vulvar Self-Examination, Health Knowledge,Practices,Attitudes, Vulva Disease
- Trial name
- SVE (NCT07479459)
- Testing
- Brochure, Peer Education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Extramammary Paget's Disease, Extramammary Paget Disease
Gynecologic Extramammary Paget's Disease
In addition to evaluating treatment outcomes, tissue samples and swabs will be collected as part of this study to allow physicians to better understand Extramammary Paget's Disease (EMPD).
- Conditions
- Extramammary Paget's Disease, Extramammary Paget Disease, Paget Disease, Extramammary, Extramammary Paget's Disease of Vulva (Diagnosis)
- Trial name
- NCT03564483
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Paget Disease of the Vulva, Vulva Cancer
ECT STUDY High-grade or Initially Invasive Vulva - GinOnc-ECT Study
Patients with a new diagnosis or recurrence of high-grade squamous precancerous lesions or initially non-invasive vulvar Paget's disease, who have not undergone other types of treatment, will be considered at the Fondazione…
- Trial name
- NCT06715592
- Testing
- Bleomicina
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vulvar Dysplasia, HPV-Related Vulvar Intraepithelial Neoplasia
Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3)
This is a Phase I, proof-of-concept treatment study to evaluate the safety, tolerability and feasibility of topical artesunate ointment to treat high grade vulvar intraepithelial neoplasia (HSIL VIN2/3).
- Conditions
- Vulvar Dysplasia, HPV-Related Vulvar Intraepithelial Neoplasia, Preinvasive Vulvar Disease, Vulva Intraepithelial Neoplasia
- Trial name
- ART-VIN (NCT03792516)
- Testing
- artesunate ointment 40%
- Where
- 4 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Genital Diseases, Female, Vulva
Correlation of Clitoral Hood and Labia Minora Measurements and Female Genital Self Image Scale (FGSIS) Scores in Women
To evaluate the relationship between women's labium minora and clitoral hood measurements and Female Genital Self Image Scale (FGSIS) scores.
- Trial name
- NCT06134596
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Lichen Planus of Vulva, Female Genital Disease
The AP-GELP Study: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus
Genital erosive lichen planus (GELP) is a chronic inflammatory disease causing painful genital sores and scarring in women. Treatment options are limited and often unsatisfactory.
- Trial name
- NCT03656666
- Testing
- Apremilast
- Where
- Norway
- Volunteers
- 42 people
- Sponsor
- Oslo University Hospital
Normal Vulval Skin, Lichen Sclerosus
Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease
Can vibrational spectroscopy be used to accurately assess vulval skin conditions? Vulval skin disorders are common and the diagnosis of these conditions can be difficult.
- Conditions
- Normal Vulval Skin, Lichen Sclerosus, High Grade Dysplasia - Usual Type ('VIN 2-3'), High Grade Dysplasia - Differentiated Type ('VIN 2-3')
- Trial name
- Vulval VS (NCT02223975)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Borderline Ovarian Clear Cell Tumor, Borderline Ovarian Serous Tumor
Collecting Tumor Samples From Patients With Gynecological Tumors
This laboratory study is collecting tumor tissue and blood samples from patients with gynecologic tumors. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help in…
- Conditions
- Borderline Ovarian Clear Cell Tumor, Borderline Ovarian Serous Tumor, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
- Trial name
- NCT00897442
- Testing
- Laboratory Biomarker Analysis
- Where
- 187 sites in United States
- Volunteers
- 275 people
- Sponsor
- Gynecologic Oncology Group
Paget's Disease of the Vulva
Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease
This is a phase II open-label study of the activity and safety of trastuzumab in patients with vulvar Paget's disease with overexpression of HER2 on biopsy.
- Trial name
- NCT01427244
- Testing
- trastuzumab
- Where
- United States
- Sponsor
- Yale University