Clinical trials: Vulvar Disease
Vulvodynia, Provoked Vulvar Vestibulodynia
Physiotherapy Intervention for Provoked Vulvar Vestibulodynia
Hypothesis: 1. Specific physiotherapy interventions will decrease pain, improve pelvic floor motor control, increase self efficacy, improve sexual function and decrease pain catastrophizing behaviour in women with provoked vulvar…
- Trial name
- NCT01628679
- Testing
- Physical therapy treatment
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University of British Columbia
Acinar Cell Carcinoma, Adenoid Cystic Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may…
- Conditions
- Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma, Adrenal Gland Pheochromocytoma
- Trial name
- NCT02834013
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 1,007 sites in United States, Guam
- Volunteers
- 798 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Melanoma
Safety, Tolerability and Pharmacokinetics Investigation of Stimotimagene Copolymerplasmid
The purpose of this study is to evaluate the safety and tolerability of different doses and administration regimens of Stimotimagene copolymerplasmid in patients with histologically confirmed diagnosis of solid tumor and/or its…
- Conditions
- Sarcoma, Melanoma, Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms
- Trial name
- NCT05578820
- Testing
- Stimotimagene copolymerplasmid, Ganciclovir
- Where
- 4 sites in Russia
- Volunteers
- 21 people
- Sponsor
- Gene Surgery LLC
Ovarian Neoplasms, Endometrial Neoplasms
A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)
Multicenter, randomized, open-label, phase II clinical study comparing Dostarlimab +/- Bevacizumab with standard chemotherapy in patients with gynecological clear cell carcinoma.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms, Vulvar Cancer
- Trial name
- DOVE (NCT06023862)
- Testing
- Dostarlimab, Bevacizumab, Doxorubicin
- Where
- 27 sites in Australia, Hong Kong and 5 more
- Volunteers
- 198 people
- Sponsor
- Yonsei University
Candida Vulvovaginitis
Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis (VANISH 303)
This is a Phase 3, randomized, multicenter, double-blind, placebo-controlled study to evaluate the efficacy and safety of oral Ibrexafungerp (SCY-078) compared to placebo in female subjects 12 years and older with AVVC.
- Trial name
- NCT03734991
- Testing
- Ibrexafungerp
- Where
- 25 sites in United States
- Volunteers
- 376 people
- Sponsor
- Scynexis, Inc.
Melanoma, Breast Carcinoma
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb20717, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity…
- Conditions
- Melanoma, Breast Carcinoma, Hepatocellular Carcinoma, Urothelial Carcinoma
- Trial name
- DUET-2 (NCT03517488)
- Testing
- XmAb20717
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Xencor, Inc.
Human Papillomavirus Associated Carcinomas, Cervical Cancer
SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
A multicenter, open, single arm dose escalation and dose expansion phase I study to evaluate the safety, tolerability, and efficacy of SCG142 TCR-T cells in Subjects with advanced HPV associated carcinomas.
- Conditions
- Human Papillomavirus Associated Carcinomas, Cervical Cancer, Head and Neck Cancers, Anal Cancer
- Trial name
- NCT06544720
- Testing
- SCG142 TCR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Gynecologic Cancer, Cervical Cancer
Intraoperative Microscopic Assessment of Lymph Node Status in Gynecological Malignancies
The IMAGINE study is a monocentric, observational, prospective study evaluating the diagnostic performance of Full-Field Optical Coherence Tomography (FF-OCT) combined with Dynamic Cell Imaging (DCI) (Van Gogh System, AQUYRE…
- Conditions
- Gynecologic Cancer, Cervical Cancer, Endometrial Cancer, Ovary Cancer
- Trial name
- IMAGINE (NCT07702721)
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Vulvodynia
A Pilot Study on the Efficacy of Oral Low Dose Naltrexone for Vulvodynia
The goal of this observational pilot study is to assess the safety, efficacy, and tolerability of oral low dose naltrexone (LDN) in the treatment of vulvodynia.
- Trial name
- NCT07862400
- Testing
- Low Dose Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Lichen Sclerosus of Vulva
Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva
Lichen sclerosus is a chronic dermatosis of the skin and semimucous membranes, characterized by the presence of well-defined atrophic white papules or plaques, which appear mainly on the skin of the anogenital region of both…
- Trial name
- PRGF (NCT05364515)
- Testing
- PRGF, Clobetasol Propionate
- Sponsor
- Fundación Eduardo Anitua
Provoked, Localized Vulvodynia, Provoked Vestibulodynia
Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study
The investigators research project is a randomized, controlled, single-blinded, feasibility pilot study. The investigators will study the feasibility of a novel treatment for women with Provoked Localized Vulvodynia (PLV) with…
- Conditions
- Provoked, Localized Vulvodynia, Provoked Vestibulodynia, Vulvar Vestibulitis, Vulvodynia
- Trial name
- NCT01996384
- Testing
- Classical Acupuncture, Non-classical acupuncture, Lidocaine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Oregon College of Oriental Medicine
Vulvar Dysplasia, Vaginal Dysplasia
A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia
1. To compare the recurrence rate between the use of laser vaporization and ultrasonic surgical aspiration in the treatment of vulvar and vaginal dysplasias 2.
- Trial name
- NCT00394758
- Testing
- CO2 laser surgery, ultrasonic surgical aspiration
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University Hospitals Cleveland Medical Center
Vulvodynia, Dyspareunia
Therapy to Prevent Sexual Pain in Breast Cancer Survivors
The purpose of this protocol is to determine whether pain with sexual intercourse can be reduced in menopausal, breast cancer survivors and to evaluate the effectiveness of a non-hormonal therapy (Lidocaine Liquid) vs.
- Conditions
- Vulvodynia, Dyspareunia, Breast Cancer, Menopause
- Trial name
- NCT01539317
- Testing
- Topical liquid lidocaine, Topical saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OHSU Knight Cancer Institute
Vulvovaginal Candidiasis
Multi-Gyn FloraFem Study for Treatment of Vulvo Vaginal Candidiasis Symptoms
Women diagnosed with Vulvovaginal Candidiasis by the health care professional will be enrolled in the study. All participants should fulfil inclusion and exclusion criteria. The study product will be used for 5 days, once a day.
- Trial name
- NCT05552378
- Testing
- Multi-Gyn FloraFem
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karo Pharma AB
Primary Sjögren Syndrome, Vaginitis Candida
Sjögren and Gynecologic Considerations
Sjögren's syndrome is an autoimmune disorder characterized by glandular and extra-glandular manifestations. It is called primary Sjögren's syndrome (pSS) in absence of another connective tissue disease.
- Conditions
- Primary Sjögren Syndrome, Vaginitis Candida, Vaginitis, Sexual Dysfunction
- Trial name
- NCT05670535
- Testing
- Visual analogue scale (VAS) for dyspareunia, Visual analogue scale (VAS) for vaginal dryness, The European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Uterine Cancer, Ovarian Cancer
Pelvic Floor Disorders in Survivors of Gynecologic Malignancies
Pelvic Floor dysfunction affects the quality of life of women. However, the prevalence and risk factors for pelvic floor disorders (PFD) in survivors of gynecologic malignancies are not known.
- Conditions
- Uterine Cancer, Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01370122
- Testing
- Survey
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Vulvovaginal Candidiasis
The Study Of Fluconazole For Vulvovaginal Candidiasis
As for the indication of vulvovaginal candidiasis, a single oral administration of fluconazole 150 mg has been approved and is recommended by guidelines overseas.
- Trial name
- NCT01806623
- Testing
- Fluconazole
- Where
- 10 sites in Japan
- Volunteers
- 157 people
- Sponsor
- Pfizer
Vulvar Lichen Sclerosus
Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen Sclerosus
This study is being done to compare the effects, good and bad, of fractionated CO2 laser treatment and clobetasol propionate .05% ointment on vulvar lichen sclerosus.
- Trial name
- CuRLS (NCT02573883)
- Testing
- Fractionated Carbon Dioxide Laser, Clobetasol Propionate 0.05% ointment
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medstar Health Research Institute
Lichen Sclerosus of Vulva
Nemolizumab for LS
Patients ≥ 18 years of age with Lichen sclerosis (LS)
- Trial name
- NCT07704775
- Testing
- Nemolizumab 30 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center