Clinical trials: Vulvar Disease
Urinary Incontinence, Stress
Tension-free Vaginal Tape (TVT) Versus Bulking Agent for the Treatment of Post Vulvectomy Urinary Incontinence
The surgical treatment of vulvar cancer is characterized by a radical approach as standard, often associated to an important rate of functional complications.
- Trial name
- NCT01148290
- Testing
- Tension free vaginal tape, Bulking agent injection
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Cervical Cancer, Endometrial Cancer
MR-HIFU for Recurrent Gynaecological Cancer
The primary objective of this pilot study is to determine whether or not it is feasible to use MRgHIFU to treat symptomatic (pain, bleeding) recurrent pelvic malignancy with an acceptable safety profile when conventional…
- Conditions
- Cervical Cancer, Endometrial Cancer, Uterine Cancer, Ovarian Cancer
- Trial name
- HIFU-Gynae (NCT02714621)
- Testing
- Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cervical Carcinoma, Vaginal Carcinoma
HPV Vaccine, Imiquimod, and Metformin Combination Trial
The goal of this clinical trial is to explore whether additional treatments can help strengthen the participant's immune system to fight cancer caused by the Human Papillomavirus (HPV), a virus spread through intimate…
- Conditions
- Cervical Carcinoma, Vaginal Carcinoma, Vulvar Carcinoma, HPV (Human Papillomavirus)-Associated Carcinoma
- Trial name
- HPV-VIM (NCT06686043)
- Testing
- HPV vaccine, Imiquimod, and metformin combination therapy
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Baylor College of Medicine
Vulvar Lichen Sclerosus
StrataMGT for the Treatment of Vulvar Lichen Sclerosus
This study is designed to evaluate the efficacy and safety of StrataMGT for the treatment of vulvar lichen sclerosus.
- Trial name
- NCT06360705
- Testing
- StrataMGT
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Center for Vulvovaginal Disorders
Candidiasis, Vulvovaginal
Study Evaluating the Optimal Dosage for Equivalence Between Lcr Regenerans® Capsules and Tablets (Lactobacillus Rhamnosus Lcr35®) on the Vaginal Flora Colonisation
The primary objective of this study is to study the vaginal flora colonisation equivalence between the tablet and capsule dosage forms of a treatment with Lcr Regenerans® between D0 (V1) and Dend of treatment.
- Trial name
- COMPRIGEL (NCT02730494)
- Testing
- Lcr Regenerans® vaginal capsules, Lcr Regenerans® vaginal tablet
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biose
Vulvar Lichen Sclerosus
Evaluation of Vulvar Lichen Sclerosus Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma.
LIQUENIA clinical trial is a phase II, controlled, prospective and unicentric study to assess vulvar lichen sclerosus (VLS) treatment using adipose tissue associated with autologous platelet-rich plasma (PRP) coming from the…
- Trial name
- NCT03961126
- Testing
- Injection of autologous fatty tissue associated with autologous platelet-rich plasma., Corticosteroids (clobetasol 0.05%)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Cervical Cancer, Endometrial Cancer
Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer
RATIONALE: Learning about the effect of nutritional supplements on quality of life in patients receiving chemotherapy for cancer may help doctors plan the best treatment.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00905658
- Testing
- therapeutic nutritional supplementation, standard follow-up care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Oscar Lambret
Vulvar Cancer
Clinical Implementation of Surface-guided Radiation Therapy in Vulvar Cancer
This prospective study evaluated the clinical implementation value of an optical surface monitoring system (OSMS) in the radiotherapy setup for patients with vulvar cancer, compared to standard laser-based setup
- Trial name
- NCT05853549
- Testing
- optical surface monitoring system
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Vulvar Neoplasm
New Strategy for the Treatment of Vulvar Cancer
Vulvar cancer is a rare disease that is treated with surgery, radiation and chemotherapy. When tumors are large (greater than 4 cm) or compromise the urethra (urine canal) and the anus, or when it is in the groin lymph nodes…
- Trial name
- NCT02067052
- Testing
- Surgery, radiotherapy and chemotherapy, Surgery
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Uterine Cancer, Ovarian Cancer
Pelvic Floor Disorders in Survivors of Gynecologic Malignancies
Pelvic Floor dysfunction affects the quality of life of women. However, the prevalence and risk factors for pelvic floor disorders (PFD) in survivors of gynecologic malignancies are not known.
- Conditions
- Uterine Cancer, Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01370122
- Testing
- Survey
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pancreatic Cancer, Colon Cancer
Cancer Loyalty Card Study 2 (CLOCS-2)
Cancer is one of the leading causes of mortality worldwide and is responsible for an estimated 9.6 million deaths yearly. Cancer-related deaths can be reduced if patients are diagnosed and treated early.
- Conditions
- Pancreatic Cancer, Colon Cancer, Oesophageal Cancer, Stomach Cancer
- Trial name
- (CLOCS-2) (NCT06447064)
- Testing
- Cases & Controls
- Where
- United Kingdom
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cancer Rectum, Cancer Vulva
Interventions for the Management of Perineal Cancer Pain
Pain associated with neoplasms may be of somatic, visceral, or neuropathic origin.Visceral pain or pain that is mediated by the sympathetic fibers in the perineal area associated with malignancy in the pelvis may be effectively…
- Conditions
- Cancer Rectum, Cancer Vulva, Cancer Vagina
- Trial name
- NCT06392399
- Testing
- cooled radiofrequency ,, conventional radiofrequency, neurolysis of ganglion
- Volunteers
- 60 people
- Sponsor
- Assiut University
Vulvar Intraepithelial Neoplasia, Vulvar High Grade Squamous Intraepithelial Lesion
Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia
This study is a single-center propsective clinical trial to assess the ability of fluorescence techniques to mark high-grade vulvar intraepithelial neoplasias including high-grade vulvar squamous intraepithelial lesions and…
- Conditions
- Vulvar Intraepithelial Neoplasia, Vulvar High Grade Squamous Intraepithelial Lesion, Differentiated Vulvar Intraepithelial Neoplasia
- Trial name
- PhotodiVIN (NCT05104099)
- Testing
- Metvixia Topical Cream
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Institut de Cancérologie de Lorraine
Vaginal Candida
Study on the Safety of the Approved Product Empedic L Cream During Its Routine Use (Active Ingredient is Clotrimazole 1%)
Researchers already did trials that showed Empecid L Cream worked for patients with Vaginal yeast infection who were in those trials.
- Trial name
- NCT03599323
- Testing
- Clotrimazole 1% (Empecid L Cream, BAYB5097)
- Where
- Japan
- Volunteers
- 1,033 people
- Sponsor
- Bayer
Menopause
The Effects of a Novel Probiotic Supplement on Menopausal Symptoms and Bone Health
This Phase II study is designed to evaluate the potential effects of a novel probiotic supplement on the severity of global menopause symptoms (e.g., psychological, somatic, urogenital symptoms) and on bone health in…
- Trial name
- MPS (NCT04001088)
- Testing
- Probiotic
- Where
- 5 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Cervical Cancer, Endometrial Cancer
Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer
RATIONALE: Fondaparinux may help prevent blood clots from forming in patients who are undergoing surgery for gynecologic cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00381888
- Testing
- fondaparinux sodium
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Vulvar Cancer
Indocyanine Green Fluorescence Imaging, Sentinel Lymph Node Mapping in Patients With Vulvar Cancer
The potential of the administration of indocyanine green (ICG) allows the execution of SLN biopsy, avoiding the multiple administrations of radiocolloid in the pre-operative phase, painful for the patient, elimination, and…
- Trial name
- NCT04663412
- Testing
- Sentinel lymph node mapping with indocyanine green fluorescence imaging in vulvar cancer (FIGO Stage IB)
- Where
- Italy
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera per l'Emergenza Canizzaro
Vulva Cancer, Vulva Neoplasm
Neo-adjuvant Pembrolizumab in Vulvar Squamous Cell Carcinoma: a Clinical Proof-of-concept Study
Rationale: Vulvar squamous cell carcinoma (VSCC) is a rare cancer with a rising incidence. Standard treatment comprises wide local excision of the primary tumour and inguinal lymph nodes and sometimes (chemo) radiotherapy.
- Conditions
- Vulva Cancer, Vulva Neoplasm, Squamous Cell Cancer
- Trial name
- Apollo (NCT05761132)
- Testing
- Pembrolizumab
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Vulvar Lichen Sclerosus
Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus
Lichen sclerosus is a rare, chronic cutaneous disorder with a predilection for the genital area. Any age group may be affected, although it is seen more often in postmenopausal women.
- Trial name
- NCT01400022
- Testing
- UVA1 phototherapy, Cortisone
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Recurrent Vulvovaginal Candidiasis
A Phase IIb/III Study of Prof-001 for the Treatment of Patients With Recurrent Vulvovaginal Candidiasis (RVVC)
This is a prospective, randomized, multi-center, active-controlled, double-blind, double-dummy, multicenter, non-inferiority study comparing the clinical efficacy, safety and tolerability of ProF-001 to fluconazole.
- Trial name
- NCT04734405
- Testing
- Prof-001, Fluconazole 150 mg
- Where
- 29 sites in Austria, Poland and 1 more
- Volunteers
- 432 people
- Sponsor
- ProFem GmbH