Clinical trials: Vulvar Vestibulitis
Localized Provoked Vulvodynia
The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia
The proposed study will evaluate how personality characteristics, cognitive factors and the emotional and behavioral responses of patients with provoked vestibulodynia (localized provoked vulvodynia) influence the natural history…
- Trial name
- NCT02892214
- Testing
- Pelvic floor physical therapy, estriol cream (ovestin), Low-level-laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Vulvodynia
CO2 Laser vs Lidocaine for Vestibulodynia in Premenopausal Women
CO2 laser energy is currently used widely for the treatment of postmenopausal women who have vaginal atrophy due to the lack of estrogen.
- Trial name
- NCT05336825
- Testing
- CO2 laser, Lidocaine patch 5%
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Dyspareunia
What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?
Dyspareunia, or pain experienced by women during penetrative sexual activities, affects the psychological and sexual health of more than one in five Canadian women [1], yet its pathophysiology is poorly understood [2-4] and…
- Trial name
- NCT04234555
- Testing
- Corticomotor excitability to the pelvic floor muscles, Pelvic floor muscle response to pressure applied at the vulvar vestibule, Pressure pain threshold (PPS)
- Where
- Canada
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Provoked Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - a Feasibility Study
This study examines feasibility of R\&D activities in the planned randomized controlled trial where effectiveness of somatocognitive therapy intervention will be compared to treatment as usual in provoked vestibulodynia.
- Trial name
- ProLoVe (NCT04208204)
- Testing
- somatocognitive physiotherapy
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Vestibulodynia (VBD) From at Least 6 Months
Ultrasound Evaluation and Vestibular Perception Thresholds Changes in Women Affected by Vestibulodynia (VBD) After One Cycle of Pixel CO2-Alma Fractionated Laser
Vestibulodynia (VBD), term revised by Consensus Terminology and Classification of Persistent Vulvar Pain and Vulvodynia in 2015, is a vulvar pain of at least 3 months' duration, without clear identifiable cause and localized at…
- Trial name
- NCT05156489
- Testing
- Fractionated Laser (Pixel CO2-Alma)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Provoked Localized Vulvodynia
Subtypes of Provoked Vestibulodynia
The proposed study will evaluate a clinical algorithm for the diagnosis and treatment of provoked vestibulodynia (PVD). The algorithm, distinguishes between four subtypes of PVD: hormonally mediated PVD, hypertonic pelvic floor…
- Trial name
- NCT02712814
- Testing
- Topical hormonal cream (estrogen), Pelvic floor physical therapy, Low Level Laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Vulvar Vestibulitis, Vulvar Diseases
Botox on Vulvar Vestibulitis
The study seeks to evaluate the effect of botulinum toxin on vulvar vestibulitis (VVS) after local injection with Botox, a potential treatment to relieve patients of vulvar pain, reducing the need for painkillers, and improving…
- Trial name
- NCT00119886
- Testing
- Botulinum toxin
- Where
- 2 sites in Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Provoked Vestibulodynia
The Use of Low Intensity Shock Wave Therapy for the Treatment of Provoked Vestibulodynia Disorder (PVD)
Provoked vestibulodynia (PVD) is an exhausting pain syndrome that immensely affects quality of sexual life, and consequently negatively affects quality of life.
- Trial name
- NCT04545255
- Testing
- Shockwave treatment
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC
Vulvodynia, Provoked Vestibulodynia
Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain
The main purpose of this study is to assess conception, pregnancy, childbirth, and pain experiences among women who have been diagnosed with vulvodynia.
- Trial name
- PRECIOUS (NCT01731288)
- Where
- Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vulvodynia, Vulvar Vestibulitis
Dysbiosis in Localized Provoked Vulvodynia (LPV)
Currently, the pathogenesis of Localized Provoked Vulvodynia (LPV) has not been elucidated. Few observations may point to involvement of the microbiome: the association of LPV with preceding chronic recurrent candidiasis, and the…
- Trial name
- DMLPV (NCT02393911)
- Testing
- Low Oxalate Diet
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Healthy, Vulvodynia
Pelvic Floor Myofascia: A New Player Involved in Vulvodynia
This study aims to develop novel ultrasound evaluation techniques to characterize the different pelvic myofascial tissues and to examine the intra- and inter-rater reliability of these techniques (objective 1).
- Trial name
- NCT05350618
- Testing
- Ultrasound evaluation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dyspareunia, Pregnancy
Outcomes of Delivery in Patients With Dyspareunia
The focus of this pilot study is to determine if a woman who experiences pain during sexual intercourse has a higher risk of complications during labor and delivery secondary to pelvic floor dysfunction, anxiety and intolerance…
- Conditions
- Dyspareunia, Pregnancy, Provoked Vestibulodynia, Pelvic Floor Dysfunction
- Trial name
- NCT01753258
- Where
- Israel
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Vulvar Vestibulitis
5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis
Study Hypothesis: Use of 5% topical lidocaine ointment will result in improved ability to have sexual intercourse and decreased pain scores in women with vestibulitis when compared to placebo.
- Trial name
- NCT00450242
- Testing
- 5% topical lidocaine ointment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Lichen Sclerosus, Lichen Planus
Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
The objective of the study was to determine sensitivity, specificity and diagnostic accuracy of "Three Rings Vulvoscopy" for detection of vulvar dermatosis using histopathology as the reference standard.
- Conditions
- Lichen Sclerosus, Lichen Planus, Lichen Simplex Chronicus, Vulvodynia
- Trial name
- DATRIV (NCT02732145)
- Testing
- "Three Rings Vulvoscopy" (TRIV), Histopathology
- Where
- Croatia
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Ginekološka Poliklinika Dr. Vesna Harni
Vestibulodynia (VBD), Vulvodynia
Vestibulodynia At High Resolution: Omics Approach to Improve Diagnosis
According to recent nomenclature, vulvodynia is vulvar pain without a clear identifiable cause persisting for at least 3-months and distinguished from vulvar pain caused by a specific disorder (inflammatory, neoplastic…
- Trial name
- NCT06865963
- Testing
- vulvar biopsy and blood semples
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Vestibulodynia, Vulvodynia
Savella in Treatment for Provoked Vestibulodynia
The primary aim of this study is to determine the efficacy of milnacipran in reducing pain in women with provoked vestibulodynia (PVD), a centrally mediated pain syndrome similar to fibromyalgia, that is characterized by severe…
- Trial name
- NCT01304589
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Vulvodynia
Enoxaparin as Treatment for Vulvodynia
The investigators hypothesize that injections of Low molecular weight heparin (LMWH) [enoxaparin] will reduce pain in women with vulvodynia.
- Trial name
- NCT00874484
- Testing
- Clexane (enoxaparin)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Provoked Vestibulodynia
Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia
Provoked vestibulodynia, previously called vulvar vestibulitis syndrome, is clinically defined as chronic, unexplained, vulvar pain or discomfort confined to the vulvar vestibule in response to contact or pressure.
- Trial name
- LLLT (NCT01149031)
- Testing
- LOW LEVEL LASER SYSTEM
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization