Clinical trials: Vulvar Vestibulitis
Vulvodynia
High-level Laser for Provoked Vestibulodynia
This is a randomized feasibility and acceptability study investigating the effects of laser treatment in women suffering from provoked vestibulodynia compared to a sham-laser treatment.
- Trial name
- NCT04502810
- Testing
- High-level laser therapy
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Université de Sherbrooke
Provoked Vestibulodynia
Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia
Provoked vestibulodynia, previously called vulvar vestibulitis syndrome, is clinically defined as chronic, unexplained, vulvar pain or discomfort confined to the vulvar vestibule in response to contact or pressure.
- Trial name
- LLLT (NCT01149031)
- Testing
- LOW LEVEL LASER SYSTEM
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Vulvodynia, Provoked Vestibulodynia
Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain
The main purpose of this study is to assess conception, pregnancy, childbirth, and pain experiences among women who have been diagnosed with vulvodynia.
- Trial name
- PRECIOUS (NCT01731288)
- Where
- Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Provoked Localized Vulvodynia
Subtypes of Provoked Vestibulodynia
The proposed study will evaluate a clinical algorithm for the diagnosis and treatment of provoked vestibulodynia (PVD). The algorithm, distinguishes between four subtypes of PVD: hormonally mediated PVD, hypertonic pelvic floor…
- Trial name
- NCT02712814
- Testing
- Topical hormonal cream (estrogen), Pelvic floor physical therapy, Low Level Laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Vulvodynia, Provoked Vestibulodynia
Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health
This trial will provide evidence for the effective management of pain and pain-related domains among those who experience provoked vestibulodynia (PVD) using photobiomodulation (PBM) and multimodal physiotherapy (mPT) in a…
- Conditions
- Vulvodynia, Provoked Vestibulodynia, Dyspareunia
- Trial name
- BRIGHT (NCT06660212)
- Testing
- Photobiomodulation, Multimodal physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Vulvodynia, Vulvar Vestibulitis
Acupuncture for the Treatment of Vulvodynia
A randomized controlled pilot study was conducted to evaluate the effect of an acupuncture protocol for the treatment of vulvodynia. Hypotheses: 1. Acupuncture reduces vulvar pain and dyspareunia in women with vulvodynia. 2.
- Conditions
- Vulvodynia, Vulvar Vestibulitis, Pain, Dyspareunia
- Trial name
- NCT02197429
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Schlaeger, Judith M., CNM, LAc, PhD
Provoked Vestibulodynia
Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial
Provoked vestibulodynia (PVD) is the most common form of vulvodynia and despite its high prevalence and important sexual, conjugal and psychological deleterious repercussions, effective evidence-based interventions remain…
- Trial name
- PVD/tDCS (NCT02543593)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Vulvodynia, Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked (Localized) Vestibulodynia - Randomized Clinical Trial (ProLoVe Study)
This is a two-arm randomized clinical trial assessing effectiveness of somatocognitive therapy versus treatment as usual for provoked vestibulodynia (PVD).
- Trial name
- ProLoVe (NCT04613713)
- Testing
- Somatocognitive physiotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Oslo Metropolitan University
Vulvodynia, Vulvodynia, Generalized
Effect of Acupuncture on Patient Vulvodynia Outcomes
This study evaluates acupuncture for the treatment of vulvodynia; specifically if it reduces vulvar pain and pain with intercourse. It also examines how long the effect of acupuncture lasts in women with vulvodynia.
- Conditions
- Vulvodynia, Vulvodynia, Generalized, Vulvar Vestibulitis
- Trial name
- NCT03364127
- Testing
- Active Acupuncture
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Illinois Chicago
Provoked Vestibulodynia
IncobotulinumtoxinA for Provoked Vestibulodynia With Overactive Pelvic Floor Muscle Dysfunction
This is a double-blind, placebo-controlled study evaluating the safety and efficacy of incobotulinumtoxinA (Merz) for the treatment of provoked vestibulodynia (PVD) associated with overactive pelvic floor muscle dysfunction.
- Trial name
- NCT07486830
- Testing
- Incobotulinum Toxin A
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvodynia, Vulvar Vestibulitis
Dysbiosis in Localized Provoked Vulvodynia (LPV)
Currently, the pathogenesis of Localized Provoked Vulvodynia (LPV) has not been elucidated. Few observations may point to involvement of the microbiome: the association of LPV with preceding chronic recurrent candidiasis, and the…
- Trial name
- DMLPV (NCT02393911)
- Testing
- Low Oxalate Diet
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Vulvar Vestibulitis
Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia
The purpose of the study was to compare the effectiveness of cognitive behavioural therapy (CBT) and physical therapy (PT) on pain and psychosexual outcomes in women with provoked vestibulodynia (PVD).
- Trial name
- NCT02494934
- Testing
- cognitive-behavioural therapy, physical therapy
- Volunteers
- 20 people
- Sponsor
- Queen's University
Vestibulodynia
Feasibility Study for Provoked Vestibulodynia
The feasibility and acceptability of a somatosensory rehabilitation program and an educational pain management program will be investigated in women with provoked vestibulodynia.
- Trial name
- NCT05342402
- Testing
- Somatosensory Rehabilitation Program, Educational Pain Management Program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Vulvodynia, Vestibulodynia
Effects of Flourish HEC on Localized Provoked Vulvodynia
This study is designed to determine whether improving the vaginal microbiome in women with localized provoked vulvodynia (LPV) may help improve pain better than routine care alone.
- Conditions
- Vulvodynia, Vestibulodynia, Vulvar Diseases, Vulvar Vestibulitis
- Trial name
- NCT05478746
- Testing
- BioNourish, a component of the Flourish HEC kit, Control - no intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vaginal Biome Science
Vulvodynia
CO2 Laser vs Lidocaine for Vestibulodynia in Premenopausal Women
CO2 laser energy is currently used widely for the treatment of postmenopausal women who have vaginal atrophy due to the lack of estrogen.
- Trial name
- NCT05336825
- Testing
- CO2 laser, Lidocaine patch 5%
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Provoked Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - a Feasibility Study
This study examines feasibility of R\&D activities in the planned randomized controlled trial where effectiveness of somatocognitive therapy intervention will be compared to treatment as usual in provoked vestibulodynia.
- Trial name
- ProLoVe (NCT04208204)
- Testing
- somatocognitive physiotherapy
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Provoked Vestibulodynia
Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
This randomized trial, nicknamed the COMFORT (Cognitive therapy or Mindfulness FOR Treatment of pvd) study, will compare the effects of an 8-session group Mindfulness-based Cognitive Therapy (MBCT) to an 8-session group Cognitive…
- Trial name
- COMFORT (NCT01704456)
- Testing
- Mindfulness-based Cognitive Therapy, Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- University of British Columbia
Vestibulodynia (VBD) From at Least 6 Months
Ultrasound Evaluation and Vestibular Perception Thresholds Changes in Women Affected by Vestibulodynia (VBD) After One Cycle of Pixel CO2-Alma Fractionated Laser
Vestibulodynia (VBD), term revised by Consensus Terminology and Classification of Persistent Vulvar Pain and Vulvodynia in 2015, is a vulvar pain of at least 3 months' duration, without clear identifiable cause and localized at…
- Trial name
- NCT05156489
- Testing
- Fractionated Laser (Pixel CO2-Alma)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Vestibulodynia
Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia
Chronic gynaecological pain is a major medical problem that affects 20-30% of women at different moments of their life. This largely neglected issue has a significant impact on the sexual and conjugal life of women suffering from…
- Trial name
- NCT01455350
- Testing
- Multimodal physiotherapy, lidocaine
- Where
- 2 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Université de Sherbrooke