Clinical trials: Wasting Syndrome
Nutritional Wasting, Nutritional Stunting
Ifaa Effectiveness Evaluation on Food Security and Nutrition
The Ifaa Project is a USAID-funded Resilience and Food Security Activity (RFSA) that is being implemented by Catholic Relief Services (CRS) and partners in the East Hararghe Zone of the Oromia Region in Ethiopia.
- Trial name
- NCT05825716
- Testing
- Ifaa Basic, Ifaa Enhanced, Ifaa Enhanced + Livelihoods
- Where
- Ethiopia
- Volunteers
- 3,317 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Wasting;Muscle(S)
Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.
The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.
- Trial name
- NCT03401944
- Testing
- TPN, Control
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Göteborg University
Muscle Wasting, Non-Small Cell Lung Cancer
Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum
The purpose of this study is to determine if the investigational drug GTx-024 can help patients with non small cell lung cancer increase physical function and maintain or gain muscle.
- Trial name
- NCT01355497
- Testing
- GTx-024
- Where
- 30 sites in United States
- Volunteers
- 330 people
- Sponsor
- GTx
Adrenal Hyperplasia, Congenital
Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia
The purpose of this study is to develop a more physiological approach to the management of children and adolescents with salt wasting Congenital Adrenal Hyperplasia.
- Trial name
- NCT00529841
- Testing
- Hydrocortisone sodium acetate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor College of Medicine
Malnutrition, Wasting
Nutritional Impact of Moringa Oleifera Leaf Supplementation in Mothers and Children
Studies to date on the effects of Moringa oleifera in diabetes and anemia and animal studies that examine the utility of moringa for increased milk and litter yield are of small scale, however high-quality large-scale placebo or…
- Conditions
- Malnutrition, Wasting, Growth Failure
- Trial name
- NCT04587271
- Testing
- Moringa oleifera (high dose), Moringa oleifera (low dose)
- Where
- 2 sites in Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suzanna L Attia
Nephrotic Syndrome
Ketoanalogues for Muscle Mass Loss in Nephrotic Syndrome
The goal of this non-commercial clinical trial is to assess efficacy and safety of ketoanalogues of essential amino acids in the prevention of protein-energy wasting in nephrotic syndrome.
- Trial name
- FORMA (NCT05716880)
- Testing
- Ketosteril, Medium Protein Diet (MPD)
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Military Institute od Medicine National Research Institute
Chronic Obstructive Pulmonary Disease (COPD) With Cachexia
BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia
This study will assess the pharmacodynamics, pharmacokinetics, safety and tolerability of BYM338 in patients with COPD and cachexia. The primary outcome will be a change in thigh muscle volume compared to placebo.
- Trial name
- NCT01669174
- Testing
- BYM338
- Where
- 9 sites in United States, Netherlands and 1 more
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Stunting, Wasting
Impact Evaluation of Benazir Nashonuma Program (BNP) on Stunting Among Under-five Children
The aim of the study is to evaluate the impact of Benazir Nashonuma Program (BNP) on prevalence of stunting among under-five children in low income setting of Pakistan.
- Conditions
- Stunting, Wasting, Anemia, Nutrient Deficiency
- Trial name
- NCT06025786
- Testing
- Benazir Nashonuma Program (BNP)
- Where
- Pakistan
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Oxidative Stress, Protein-Energy Wasting
Effect of Oral Nutritional Supplementation on Oxidative Stress in Protein-energy Wasting Patients With Peritoneal Dialysis
End-stage kidney disease (ESKD) represents a serious public health problem in Mexico. Data from the United States Renal Data System (USRDS) have reported that the region of Jalisco (Mexico) is one of the places with the highest…
- Conditions
- Oxidative Stress, Protein-Energy Wasting, Malnutrition, Protein-Energy Malnutrition
- Trial name
- NCT04628117
- Testing
- Oral nutritional supplementation for kidney disease
- Volunteers
- 22 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Cachexia-Anorexia Syndrome, Cachexia; Cancer
A Phase II Clinical Study Evaluating the Efficacy and Safety of SXRN Injection in Patients With Cancer Cachexia
This is a multicenter, randomized, double-blind, placebo-controlled, dose-finding Phase II clinical study to evaluate the efficacy and safety of SXRN injection in adult patients with cancer-associated anorexia-cachexia.
- Trial name
- NCT07890324
- Testing
- SXRN Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Jiangsu Guiqiong Pharmaceutical Co., Ltd.
Liver Disease Chronic, Muscle Weakness
Inspiratory Muscle Training Post-Liver Transplant
Individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. The transplant surgery additionally challenges respiratory mechanics.
- Conditions
- Liver Disease Chronic, Muscle Weakness, Respiratory Insufficiency
- Trial name
- NCT03130608
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Miami
Nutrition Disorders, Life-threatening Infection
Cotrimoxazole Prophylaxis in Severely Malnourished Children
This trial aims to test the hypothesis that mortality among Kenyan children with severe malnutrition following initial stabilisation is due to ongoing vulnerability to infectious disease, and that long term daily co-trimoxazole…
- Trial name
- CTX (NCT00934492)
- Testing
- Cotrimoxazole dispersible tablet
- Where
- 4 sites in Kenya
- Volunteers
- 1,781 people
- Sponsor
- University of Oxford
Child Malnutrition
Effectiveness and Cost-Effectiveness of Four Formulations of Food Supplements for the Prevention of Wasting and Stunting in Burkina Faso
This research will serve as a follow-up on the review of Title II commodities performed by the Food Aid Quality Review at Tufts University in October 2011.
- Trial name
- FAQR-Burkina (NCT02071563)
- Testing
- CSB14, RUSF1, SC+
- Where
- Burkina Faso
- Volunteers
- 6,039 people, healthy volunteers welcome
- Sponsor
- Tufts University
Cancer Cachexia, Cancer Cachexia Syndrome
The First in Human Study of QLS2319 in Healthy Subjects and Cancer Cachexia
Study To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of QLS2319 in Healthy Subjects and Cancer Cachexia
- Trial name
- NCT07735104
- Testing
- QLS2319
- Where
- 2 sites in China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Undernutrition, Stunting
The Effectiveness of HBM-based Education Program on Improve Knowledge and Behaviors
The randomized controlled trial design with one intervention arm (nutrition education and complementary feeding) and one control (usual care) arm (1:1 ratio).
- Conditions
- Undernutrition, Stunting, Wasting, Underweight
- Trial name
- NCT05517395
- Testing
- health nutrition education, usual care
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Underweight, Stunting
Evaluation Research of the Nutrition Interventions in the INHP II Areas of CARE India
This study is designed to evaluate the effectiveness of CARE India's Integrated Nutrition and Health Program (INHP II) to reduce malnutrition among children 0-23 months of age.
- Conditions
- Underweight, Stunting, Wasting, Anemia
- Trial name
- NCT00198835
- Testing
- Maternal nutrition and infant feeding advice
- Where
- India
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Age-associated Muscle Loss
AMG 745 in Subjects With Age-associated Muscle Loss
Randomized, Double-blind, Placebo-controlled Dose Ranging Study to Evaluate the Safety and Efficacy of AMG 745 in Age-associated Muscle Loss
- Trial name
- NCT00975104
- Testing
- AMG 745 0.3 mg/kg, AMG 745 1.0 mg/kg, AMG 745 3.0 mg/kg
- Sponsor
- Amgen
HIV Infections, Lipodystrophy
Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients
The goals of this study are to find out if fat wasting and weight loss in the arms and legs of HIV patients taking highly active antiretroviral therapy (HAART) are caused by nucleoside/nucleotide reverse transcriptase inhibitors…
- Conditions
- HIV Infections, Lipodystrophy, Wasting Disease
- Trial name
- NCT00028314
- Testing
- Abacavir sulfate, Atazanavir/Ritonavir, Lopinavir/Ritonavir
- Where
- 25 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Moderate Acute Malnutrition (MAM), Undernutrition
Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh
The goal of this clinical trial (cluster randomized controlled trial) is to learn whether a Positive Deviance/Hearth (PDH) intervention can effectively treat moderate acute malnutrition (MAM) and reduce relapse compared to…
- Conditions
- Moderate Acute Malnutrition (MAM), Undernutrition, Wasting
- Trial name
- PD/Hearth MAM (NCT07591064)
- Testing
- PD/Hearth is a behavioral change program that teaches caregivers how to cook and feed their children. A nutrient-dense meal using local ingredients will be fed to children during Hearth sessions., Standard of Care (Investigator Selected)
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- World Vision US
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London