Clinical trials: Weakness
Cushing Syndrome, Acromegaly
Muscle in Acromegaly and Cushing's Syndrome
Cushing's syndrome (CS) and acromegaly determine myopathy and muscle weakness which persist long-term after control of hormone excess.
- Trial name
- MAC (NCT03673761)
- Testing
- MRI, dual-energy, x-ray absorptiometry, muscle ultrasounds, blood testing
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Stroke
Use of Repetitive Facilitative Exercise Program in Established Stroke
The purpose of this study is to assess whether a novel therapy approach (repetitive facilitative exercise (RFE)) is more effective than conventional rehabilitation in facilitating the recovery of upper extremity function…
- Trial name
- NCT01574599
- Testing
- Occupational therapy- Repetitive Facilitative Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Neurophysiology, Physiology
Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients
Patients with COPD have lower capability of activating their muscles. At the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex.
- Trial name
- NCT03807258
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Symptoms Associated With Pelvic Floor Weakness
RF Rejuvenation for Pelvic Floor and Vagina
Evaluation of efficacy and safety of the Votiva RF system with the Forma V handpiece for vaginal treatments.
- Trial name
- NCT03536819
- Testing
- Votiva
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- InMode MD Ltd.
Postoperative Pain
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study
Adductor canal block is commonly offered to provide pain relief following knee surgery with the hope that they cause less leg weakness than traditionally performed femoral nerve block.
- Trial name
- NCT02541552
- Testing
- Ropivacaine 0.5%
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness
Efficacy of Inspiratory Muscle Training on Elite Swimmers
This study is a randomized controlled trial on the efficacy of inspiratory muscle training on swimming performance, airway dysfunction and perceived breathlessness in elite swimmers.
- Conditions
- Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness, Dyspnea
- Trial name
- PEAK (NCT03062735)
- Testing
- Inspiratory Muscle Training
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Muscular Weakness
Can Blood Flow Restriction Therapy Improve Strength for Shoulder External Rotators Better Than Exercise Alone
The purpose of this study is to evaluate the ability of blood flow restriction therapy to improve strength of shoulder muscles during the sidelying external rotation (ER) exercise versus a control group who only performs the…
- Trial name
- NCT03815760
- Testing
- Blood Flow Restriction
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Fox University
Weak; Pelvic Floor, Weak; Muscle
Effect of the Pelvic Floor Training in Postmenopausal Women With or Without Hormonal Therapy
The purpose of this study is to evaluate the effect of pelvic floor muscle training (PFMT) on muscle function of postmenopausal women using or not using hormonal therapy replacement (HTR).
- Conditions
- Weak; Pelvic Floor, Weak; Muscle, Urinary Incontinence
- Trial name
- NCT02549729
- Testing
- pelvic floor muscle training
- Where
- Brazil
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Muscle Weakness
Randomized Controlled Trial Comparing Traditional Pelvic Floor Rehabilitation to Pilates in Increasing Pelvic Muscles Strength.
The objective of this randomized controlled trial is to determine whether a standardized Pilates exercise program can effectively strengthen pelvic floor muscles when compared with conventional pelvic muscle rehabilitation.
- Trial name
- NCT00549458
- Testing
- Pilates, Pelvic muscle rehabilitation therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Muscle Weakness, Pulmonary Arterial Hypertension
Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a disease that causes raised blood pressure in blood vessels that pick up oxygen from the lungs. It has a life expectancy similar to some cancers.
- Trial name
- NCT01847716
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetic Peripheral Neuropathy, Diabetes
Diabetes, Falls, and Fractures
Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Balance; Distorted, Vestibular Neuropathy
- Trial name
- DIAFALL (NCT05389566)
- Testing
- Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Weakness, Muscle
Blood Flow Restriction Training for People With Disabilities
A large portion of the American population live with disabilities. People with disabilities can find it difficult to perform standard exercise routines. Regular exercise is necessary to be healthy, especially as people age.
- Trial name
- NCT06441422
- Testing
- Blood flow restriction training, No blood flow restriction training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Aging, Muscle Weakness
Leg Heat Therapy in Elderly Individuals
This pilot randomized, sham-controlled trial aimed to establish the feasibility and safety of home-based leg HT in community-dwelling older adults and inform the design of a future, larger study.
- Trial name
- NCT05543980
- Testing
- Leg heat therapy device
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Muscle Weakness
Effect of PROGRESSive Training and Teststerone in Older Frail Men
In this scientific clinical investigation we will test whether testosterone and progressive resistance training can improve muscle strength and reduce the risk of falls in older men.
- Trial name
- PROGRESS (NCT02873559)
- Testing
- testosterone, Progressive muscle training
- Where
- 2 sites in Denmark
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hypothyroidism Primary
The Effect of Respiratory Muscle Training on Respiratory Parameters
The goal of this randomized controlled study is to find out whether an eight-week respiratory muscle training program can improve breathing, respiratory muscle strength and endurance, physical capacity, body composition, fatigue…
- Trial name
- NCT07865975
- Testing
- Progressive Muscle Training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
IBM, Inclusion Body Myositis
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
This study will evaluate whether neuromuscular ultrasound and MRI can be used as imaging markers of bulbar involvement and swallowing dysfunction in individuals with inclusion body myositis (IBM).
- Conditions
- IBM, Inclusion Body Myositis, Myopathy, Myositis
- Trial name
- NCT07823101
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Muscle Weakness
Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters
In several diseases in which muscle weakness is a determining factor for morbidity and mortality, inspiratory muscle training has been shown to be useful in improving the function of ventilatory muscles, delaying or minimizing…
- Trial name
- NCT03258944
- Testing
- Breath-Stacking
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Aging, Inspiratory Muscle Weakness
Effect of Inspiratory Muscle Training on Diaphragm Muscle Thickness, Fatty Liver Density and Aerobic Capacity in Elderly Men: A Randomized Controlled Trial
This randomized controlled trial aims to investigate the effects of a 4-week inspiratory muscle training (IMT) program on diaphragm muscle thickness, fatty liver density, functional capacity, and quality of life in elderly men…
- Conditions
- Aging, Inspiratory Muscle Weakness, Fatty Liver, Reduced Functional Capacity
- Trial name
- IMT AND ELDERL (NCT07193082)
- Testing
- Experimental Inspiratory Muscle Training (IMT Group), Control Group: No inspiratory muscle training.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Acute Pain, Atrophic
Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy
The purpose of this study is to examine deficits in activation and motor patterns, as well as central drive in patients with rotator cuff tendinopathy.
- Conditions
- Acute Pain, Atrophic, Goals, Impairment
- Trial name
- NCT02971072
- Testing
- Subacromial injection, Physical Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oregon