Clinical trials: Weakness
Stroke, Parkinson's Disease
Inpatient Physical Activity Function Through Enhanced Participation Levels in Animal-Assisted Therapy Programs
Thousands of canines are used for therapy in health care centers throughout the United States as part of a volunteer therapy team, yet little is known about the outcomes provided by these teams.
- Conditions
- Stroke, Parkinson's Disease, Muscle Weakness
- Trial name
- NCT02606006
- Testing
- Canine Animal-Assisted Therapy, Standard of Care Physical Therapy
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
Design and Evaluation of the Effects of a Physical Therapy Program With Digital Support in Patients With Breast Cancer
Breast cancer surgery usually results in reduced range of motion of the shoulder joint, weakness of the musculature and altered scapular kinematics during movement.
- Trial name
- NCT04837248
- Testing
- Active Comparator: Group 1. Conventional treatment, Experimental: Group 2. Experimental treatment.
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Intensive Care (ICU) Myopathy
Biomechanical Properties in Intensive Care Unit (ICU) Survivors 12-month After Discharge
Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report persevering limitation of physical capacity for years after discharge.
- Trial name
- NCT01364714
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke, Chronic Stroke
Personalized Transcranial Direct Current Stimulation in Stroke Recovery
The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement…
- Conditions
- Stroke, Chronic Stroke, Hemorrhage Brain, Ischemic Stroke
- Trial name
- NCT06286800
- Testing
- Transcranial direct current stimulation (tDCS) with OT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Methodist Hospital Research Institute
Intensive Care Unit Acquired Weakness, Critical Care
CYCLE Pilot Randomized Trial
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very weak and disabled.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- CYCLE Pilot (NCT02377830)
- Testing
- In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 113 people
- Sponsor
- McMaster University
Hematologic Malignancy, Muscle Weakness
Effects of NMES and Exercise in Hematological Cancer
Physical activity levels of adult hematologic cancer patients are deficient. The resulting physical inactivity causes fatigue, muscle loss, and deterioration in physical performance values.
- Trial name
- NCT04755465
- Testing
- Neuromuscular Electrical Stimulation, Structured Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Acibadem University
Thymidine Kinase 2 Deficiency
An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
This is a Phase 2 prospective open-label treatment study of the safety and efficacy of doxecitine and doxribtimine in study participants with thymidine kinase 2 (TK2) deficiency who participated in the retrospective study…
- Trial name
- Continuation (NCT03845712)
- Testing
- doxecitine and doxribtimine
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 47 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Old Age; Debility
Safety and Feasibility of a Novel In--Bed Resistance Training Device in Elderly Inpatients
The purpose of this study is to decrease deconditioning of elderly inpatients in acute care institutions and to assess the safety and feasibility of a newly developed resistance training device.
- Trial name
- NCT04026802
- Testing
- In-Bed Resistance Training Device, Standard of Care
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Obesity (Disorder), Obesity
Effect of Vitamin D on Body Composition and Functionality of Older Adults
Older adults with obesity often experience a gradual loss of muscle mass and muscle strength, a condition sometimes described as sarcopenic obesity.
- Conditions
- Obesity (Disorder), Obesity, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT07275177
- Testing
- Vitamin D
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
Postpoliomyelitis Syndrome
Modafinil to Treat Fatigue in Post-Polio Syndrome
This study, conducted at the Walter Reed Army Medical Center, the National Rehabilitation Hospital, and the National Institutes of Health, will examine whether the drug Modafinil can decrease fatigue in patients with post-polio…
- Trial name
- NCT00067496
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epidermolysis Bullosa
Improve Adherence to Weak or Strong Opioid Analgesics at the Time of Care in Children With Hereditary Epidermolysis Bullosa
Hereditary epidermolysis bullosa (HEB) are rare genodermatoses, clinically characterized by epithelial and subepithelial fragility leading to the formation of blisters and spontaneous erosions on skin at the slightest contact…
- Trial name
- ODEB (NCT04853667)
- Testing
- Interview
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenia, Old Age; Debility
Study of the Validity and Reliability of Two Digital Dynamometers in Older People
It is a cross-sectional, randomized, and single-center study with a duration of 6 months. The study will follow the STROBE guidelines for cross-sectional studies and CONSORT 2024.
- Conditions
- Sarcopenia, Old Age; Debility, Frailty
- Trial name
- SOVARDDIOP (NCT06623019)
- Testing
- Validation and reliability
- Where
- Spain
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Patellofemoral Pain Syndrome
Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain
Background: Researchers are interested in how the muscles affect the movement of the knee cap. These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease.
- Trial name
- NCT01862731
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Cerebral Palsy, Hemiplegia
The Effect of Combined Armeospring and CIT on Neuro-motor and Functional Recovery in Children With Unilateral CP
The purpose of this study is to assess the use of a commercially available arm weight supporting training system (Armeo®Spring) in conjunction with Constraint Induced Therapy (CIT) for improving upper extremity function for…
- Conditions
- Cerebral Palsy, Hemiplegia, Upper Extremity Weakness
- Trial name
- NCT02914925
- Testing
- ArmeoSpring/CIT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St Mary's Hospital for Children
Postmenopausal Syndrome, Muscle Weakness
The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women
The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed…
- Trial name
- NCT02434185
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Mobility Limitation, Asthenia
Evaluation of Homecare Reablement, the Trondheim Model
The aim is to evaluate a model of home-based rehabilitation. The intervention targets elder persons who receive homecare services, but still are relatively independent in most activities of daily living.
- Trial name
- NCT02298374
- Testing
- Homecare reablement, usual care
- Sponsor
- Norwegian University of Science and Technology
Cervical Radiculopathy, Cervical Radicular Pain
Effects of Exercises and Electrical Current Application Aiming to Strengthen Neck and Shoulder Blades Muscles on Symptoms of a Pinched Nerve in the Neck
Cervical Radiculopathy (CR) is an objective loss of sensory and/or motor function as a result of compression or irritation of the cervical spinal nerve root.
- Conditions
- Cervical Radiculopathy, Cervical Radicular Pain, Neck Pain, Numbness
- Trial name
- NCT07375823
- Testing
- Exercise Therapy, Superimposition of electrical muscle stimulation on active movement
- Where
- Cyprus
- Volunteers
- 50 people
- Sponsor
- European University of Lefke
Muscle Loss, Muscle Weakness
Impact of Increased Protein Density Diet to Muscle Mass and Strength Among Mid-aged and Older Adults
The subjects of this intervention program are mainly based on community-dwelling mid-aged and older adults. The investigator's program will provide meals containing different proportionated protein.As this project is a double…
- Conditions
- Muscle Loss, Muscle Weakness, Fragility
- Trial name
- NCT03784456
- Testing
- 25% protein, 15% protein
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Yang Ming Chiao Tung University
Muscle Atrophy or Weakness, Ventilator-associated Lung Injury
Serial Daily Diaphragm Ultrasounds in Ventilated Patients
When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to…
- Trial name
- NCT02174029
- Testing
- Ventilation- mandatory, Ventilation- voluntary mode only, Voluntary with preceding mandatory
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Steve Reynolds
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