Clinical trials: Weakness
Neuromuscular Disease
Diagnostic Evaluation of Patients With Neuromuscular Disease
The objectives of this protocol are to: 1) screen patients with various neuromuscular disorders and facilitate their entry into appropriate research protocols; 2) help resolve puzzling diagnostic neuromuscular problems and train…
- Trial name
- NCT00015470
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sarcopenic Obesity, Muscle Weakness
Mechanisms of Age-Related Muscle Loss
Two independent, but interrelated conditions that have a growing impact on healthy life expectancy and health care costs in developed nations are the age related loss of muscle mass (sarcopenia) and obesity.
- Conditions
- Sarcopenic Obesity, Muscle Weakness, Protein Metabolism Disorder, Physical Activity
- Trial name
- NCT03113279
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Post-acute COVID-19 Syndrome
Сlinical Trial of Efficacy and Safety of Prospekta in the Treatment of Post-COVID-19 Asthenia.
The multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial. The objective of this study is to evaluate the efficacy and safety of Prospekta in the treatment of asthenia in patients after the…
- Trial name
- NCT05074888
- Testing
- Prospekta
- Where
- 32 sites in Russia
- Volunteers
- 676 people
- Sponsor
- Materia Medica Holding
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Critical Illness, Sarcopenia
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly.
- Conditions
- Critical Illness, Sarcopenia, ICU Acquired Weakness
- Trial name
- ProMoTE (NCT05326633)
- Testing
- MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Muscle Weakness, Critical Illness
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
Elderly patients who experience a prolonged ICU stay are at high risk for developing post intensive care unit syndrome (PICS), a serious medical condition manifested by loss of muscle mass, weakness, malnutrition and…
- Conditions
- Muscle Weakness, Critical Illness, Sarcopenia
- Trial name
- ExPrEs (NCT02509520)
- Testing
- MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Frail Elderly Syndrome, Muscle Weakness
Investigation of Relation With Preoperative Fragility and ASA Score in Elderly Patients
Frailty is a term specific to the geriatric period. It is used to describe weak, unstable, frail patients and partially expresses the frailty of the elderly patient.
- Trial name
- NCT05078983
- Testing
- CGA-FI (COMPREHENSIVE GERIATRIC ASSESMENT - FRAILITY INDEX)
- Where
- Turkey (Türkiye)
- Volunteers
- 320 people
- Sponsor
- Gulhane Training and Research Hospital
Cachexia, Lymphoma
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
RATIONALE: Celecoxib may help relieve moderate or severe pain associated with cancer. It may also decrease weight loss and improve muscle strength in cancer patients.
- Conditions
- Cachexia, Lymphoma, Melanoma (Skin), Ovarian Cancer
- Trial name
- NCT00093678
- Testing
- celecoxib, anticachectic therapy, nutritional support
- Sponsor
- Eastern Cooperative Oncology Group
Muscle Weakness
The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery
Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications.
- Trial name
- NCT01933841
- Testing
- TOF-Watch SX, Notify the provider
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Vanderbilt University Medical Center
Diet, Food and Nutrition, Accidental Falls
Occupational Therapy and Registered Dietitian Services to Reduce Fall Risk Among Home Delivered Meal Clients
The purpose of this study is to determine which of the following four service models is most effective for reducing fall risk among home-delivered meal clients: (1) meals alone, (2) meals + registered dietitian services, (3)…
- Conditions
- Diet, Food and Nutrition, Accidental Falls, Cardiovascular Diseases, Diabetes
- Trial name
- NCT06586970
- Testing
- Meals + RD services, Meals + OT services, Meals + RD + OT services
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Ohio State University
Stroke, Stroke Rehabilitation
Biomarkers of Reaction To HIIT Exercise
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy.
- Conditions
- Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty
- Trial name
- BReaTHE (NCT06059872)
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Old Age; Debility, Digestive Cancer
Perioperative Multicomponent Rehabilitation and Outcomes in Elderly Patients With Frailty
The study is designed to investigate the effect of a perioperative multicomponent rehabilitation pathway on early and long-term outcomes in elderly patients with frailty recovering from surgery for digestive cancer.
- Conditions
- Old Age; Debility, Digestive Cancer, Surgery, Nutrition Therapy
- Trial name
- NCT04715581
- Testing
- Preoperative nutritional optimization, Perioperative exercise training, Postoperative exercise training
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Peking University First Hospital
Hypogammaglobulinemia, Autoimmune Conditions
Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Panzyga for Prevention of Major Infection in Patients with Hypogammaglobulinemia and Autoimmune or Rheumatic…
- Conditions
- Hypogammaglobulinemia, Autoimmune Conditions, Rheumatic Conditions, Infections
- Trial name
- NCT07220915
- Testing
- Panzyga, 10% Intravenous Solution
- Where
- 25 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Octapharma
Bariatric Surgery Candidate, Muscle Weakness
Inspiratory Muscle Training and Pulmonary Function in Patients Submitted to Bariatric Surgery
Obesity is defined as a body mass index greater than or equal to 30 kg / m2 and represents a public health problem that affects the world population.
- Conditions
- Bariatric Surgery Candidate, Muscle Weakness, Complication,Postoperative, Respiratory Muscle
- Trial name
- NCT05575089
- Testing
- Inspiratory muscle training - Powerbreath, Aerobic exercise in cycle ergometer, Deep breathing exercises
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Universidade Cidade de Sao Paulo
Low Back Pain, Rehabilitation Program
Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients
The study evaluate paraspinal aerobic metabolism of chronic low back pain patients and healthy people during an original and standardized isokinetic protocol.
- Conditions
- Low Back Pain, Rehabilitation Program, Muscular Weakness
- Trial name
- OXYLOM (NCT03055182)
- Testing
- Physical rehabilitation program
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Old Age; Debility, Loneliness
The Effect of Home Visit Supported Nursing Education Program on Some Parameters in Elderly People Living Alone at Home
It is aimed to develop healthy lifestyle behaviors of elderly people living alone at home, reduce their loneliness levels and increase their social support capacity.The research was planned as a quasi-experimental research.
- Conditions
- Old Age; Debility, Loneliness, Healthy Lifestyle
- Trial name
- NCT06517615
- Testing
- Home Visit Supported Nursing Training Program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kastamonu University
Emphysema or COPD
Improve Muscle Weakness in Patient With COPD
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07649850
- Testing
- Aerobic Exercise Combined with Blood Flow Restriction, Aerobic exercise
- Sponsor
- Al-Zaytoonah University of Jordan
Sleep Disorder, Insomnia
Brain Gym Therapy on Quality of Sleep Among Elderly People
This clinical trial aims to evaluate the impact of Brain Gym Therapy on the quality of sleep among elderly individuals attending healthcare facilities.
- Conditions
- Sleep Disorder, Insomnia, Cognitive Function Abnormal, Old Age; Debility
- Trial name
- BG/E (NCT06553690)
- Testing
- Brain Gym Therapy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intensive Care Unit Syndrome, Muscle Weakness
Effect of Critical Patients Mobilization on Respiratory and Peripheral Muscle Strength and Functional Capacity.
To analyze changes on respiratory muscle strength, peripheral and functional capacity of critically ill patients with clinical and surgical etiology, breathing spontaneously and bedridden, within 48 hours of admission to the…
- Trial name
- NCT02919085
- Testing
- Early ambulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
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