Clinical trials: Weakness
Chronic Obstructive Pulmonary Disease
Identification of Explanatory Factors for the Lack of Muscle Strength Gain Following a Pulmonary Rehabilitation Program in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease associated with various comorbidities, including muscle weakness (MW), which is very worrying due to its negative impact on patients' quality of life…
- Trial name
- NCT06271122
- Testing
- Voluntary activation assessed by magnetic stimulation
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Korian
Sepsis
Project 4A: Inspiratory Muscle Training and Diaphragm Strength
Investigators will assess the effect of exercise on markers of inflammation and protein catabolism. This research study will further our understanding of how treating Chronic Critical illness (CCI) - related respiratory muscle…
- Trial name
- NCT02367170
- Testing
- Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Muscle Weakness, Critical Illness
Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients
The investigators hypothesize that by applying a validated algorithm to accomplish early mobilization in surgical intensive care unit (ICU) patients, these patients will achieve a higher level of mobility which translates to…
- Conditions
- Muscle Weakness, Critical Illness, Respiratory Insufficiency
- Trial name
- mSOMS (NCT01363102)
- Testing
- SOMS
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Pregnancy Related
Effects of Antenatal Exercises on Maternal Birth Outcomes
The study is aimed to determine the effects of pelvic floor stretching Vs strengthening on maternal birth outcomes and postpartum urogenital distress in primigravida.
- Trial name
- NCT05936866
- Testing
- Pelvic floor stretching, Pelvic floor strengthening
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Muscle Weakness or Atrophy, Mechanical Ventilation Complication
NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.
Particularly, muscle respiratory wasting will occur early (18 to 69 hours) in up to 60% of patients with mechanical ventilation (MV), leading rapidly to diaphragmatic weakness, which is associated with prolonged MV use, longer…
- Conditions
- Muscle Weakness or Atrophy, Mechanical Ventilation Complication, Electrical Stimulations
- Trial name
- NCT05536531
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Intensive Care Unit Acquired Weakness
Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.
Critically ill patients are known to develop serious nutritional deterioration during the course of their disease. They develop, from the beginning, a multifactorial protein malnutrition that relates to a poor clinical course and…
- Trial name
- FISIO (NCT05918757)
- Testing
- Protein dose 1.5 g/kg/day, Protein dose 1.0 g/kg/day
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Critical Care Medicine and Coronary Units
Postpoliomyelitis
Brain Physiology in Polio Survivors
OBJECTIVE: Many persons who survive poliomyelitis develop pain, weakness, and fatigue many decades later. It is not known why some persons develop this syndrome and others do not.
- Trial name
- NCT00080600
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Muscular Weakness
Enhancing Gluteus Maximus Recruitment
Can participants enhance gluteus maximus recruitment during a single-leg squat test following a neuromuscular training program?
- Trial name
- NCT02042937
- Testing
- Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gait Impairment, Cerebral Palsy (CP)
Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting
The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program…
- Conditions
- Gait Impairment, Cerebral Palsy (CP), Neuromuscular Diseases (NMD), Spinal Cord Injuries (SCI)
- Trial name
- NCT07745712
- Testing
- ABLE Kids
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- ABLE Human Motion S.L.
Cardiac Surgery, Muscle Weakness | Patient
Pulmonary Function, Muscle Strength, and Functional Capacity in Minimally Invasive Cardiac Surgery
The goal of this observational study is to evaluate pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity in adult patients undergoing either minimally invasive cardiac surgery (via…
- Conditions
- Cardiac Surgery, Muscle Weakness | Patient, Pulmonary Function, Functional Capacity
- Trial name
- NCT07172529
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zehra Can Karahan
Sepsis
Dysfunctions of Human Muscle Stem Cells in Sepsis
Severe critical illness is often complicated by Intensive Care Unit - Acquired Weakness (ICU-AW), which is associated with increased in and post-ICU mortality, with delayed weaning from mechanical ventilation and with long-term…
- Trial name
- DISCUSS (NCT02789995)
- Testing
- Human biological samples
- Where
- 7 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Advance Care Planning, Multimorbidity
ACP in Older Patients With Multimorbidity: a Randomized Pilot
Rationale A recent study into the patient perspective of patients with multiple chronic conditions in the Netherlands underlines the strain multimorbidity can put on people.
- Conditions
- Advance Care Planning, Multimorbidity, Old Age; Debility, Health Economics
- Trial name
- NCT04856202
- Testing
- Advance Care Planning interview
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Cerebral Palsy, Central Nervous System Diseases
Power Training Combined With Interval Treadmill Training
Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life.
- Conditions
- Cerebral Palsy, Central Nervous System Diseases, Brain Damage, Chronic
- Trial name
- PT³ (NCT03625570)
- Testing
- Power training combined with interval treadmill training, Strength training combined with traditional treadmill training
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
ICU Acquired Weakness
The Use of Musculoskeletal Ultrasound for the Detection of ICU-Acquired Weakness
Intensive Care Unit-Acquired Weakness (ICU-AW) is a clinical entity frequently encountered in critically ill patients that have both short term and long-term implications.
- Trial name
- NCT05048953
- Testing
- Muscle ultrasound measurements (the index test)
- Where
- Nepal
- Volunteers
- 114 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
DLBCL, Old Age; Debility
Dose Dense Chemotherapy in Elderly Patients > 80 Years Old With DLBCL
Multi-center retrospective analysis of patients with DLBCL aged ≥80 years old treated with R-CHOP-14 compared to other regimens.
- Trial name
- NCT06150053
- Where
- Germany
- Volunteers
- 79 people
- Sponsor
- University Hospital, Saarland
Pregnancy Related, Labor; Poor
Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy
Today it remains a challenge to successfully both halt and induce labor progression. Induction of labor is a common obstetric intervention that 1 in 4 women will experience.
- Conditions
- Pregnancy Related, Labor; Poor, Uterine Contractions Weak
- Trial name
- NCT04521972
- Testing
- Room light/light bulb
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Healthy Volunteers
Effects of Running Shoe Sole Hardness on Vibration and Neuromuscular Fatigue During a Half-marathon Run on a Treadmill
During running, each contact between the foot and the ground causes an impact. Ground reaction forces (GRF) are considered as an input into the musculoskeletal system.
- Trial name
- FAT-VIB (NCT06110637)
- Testing
- "hard shoes" runners evaluation, "Soft shoes" runners evaluation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Covid19, Anosmia
Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN)
The main aim of this study is to determine the effects of short-term treatment with hesperidin on COVID-19 symptoms in comparison with a placebo.
- Conditions
- Covid19, Anosmia, Fever, Cough
- Trial name
- Hesperidin (NCT04715932)
- Testing
- Hesperidin
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Montreal Heart Institute
ICU Acquired Weakness
Neurophysiological Diagnosis for ICU Septic Shock Patients
Patients hospitalized in the Intensive Care Unit (ICU) are at risk for developing severe disabilities, physical or cognitive. In particular, ICU-acquired weakness is frequent.
- Trial name
- EDX (NCT03802500)
- Testing
- Nerve conduction study
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
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