Clinical trials: Weaning, open to volunteers
Pneumonia
Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia
this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia • HYPOTHESES: It will be hypothesized that…
- Trial name
- NCT06835842
- Testing
- rib mobilization technique, routine chest physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Acute Hypoxemic Respiratory Failure, High-flow Nasal Oxygen Therapy
Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care
High-flow nasal oxygen therapy (HFNO) is an oxygenation technique frequently used in intensive care. The main objective of our study is to show that the use of a protocol for weaning patients off high-flow nasal oxygen therapy…
- Trial name
- HiFloWEAN (NCT06104956)
- Testing
- HFNO weaning protocol, HFNO Standard of care
- Where
- 11 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Tours
Assess the Prediction of Successful SBT and Extubation of Trachea by Bedside Lung Ultrasound in Mechanically Ventilated Patients
Prediction of Weaning Outcome From Mechanical Ventilation Using Ultrasound
Examine the predictive value of lung ultrasound in assessing the success of SBTs and tracheal extubation among patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT06685224
- Testing
- Ultrasound Assessment of the aeration of lung tissue and Parasternal Intercostal Muscle Thickness
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Tracheostomized Patients, Mechanical Ventilation Weaning
High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients
In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill…
- Conditions
- Tracheostomized Patients, Mechanical Ventilation Weaning, High Flow Oxygen Therapy
- Trial name
- HFTO-WEAN (NCT07559591)
- Testing
- High-flow tracheal oxygen (HFTO), Tracheal Mask (TM)
- Where
- Saudi Arabia
- Volunteers
- 88 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Physiological Parameters
Effect of Implementing Cough Augmentation Techniques on Weaning Outcomes Among Critically Ill Patients
The study aims to determine the effect of implementing cough augmentation techniques on weaning outcomes among critically ill patients
- Trial name
- NCT07722260
- Testing
- cough augmentation techniques
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Heba.Attia@nur.dmu.edu.eg
Liberation From Mechanical Ventilation
The Accuracy of Combined Parasternal Intercostal Muscle Thickening Fraction and Diaphragmatic Excursion in Predicting Failure of Libration From Mechanical Ventilation
Approximately 20% of patients in the intensive care unit (ICU) requiring mechanical ventilation (MV) experience difficulty and prolonged weaning.
- Trial name
- NCT07702422
- Volunteers
- 70 people
- Sponsor
- Cairo University
Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial
Non-medicinal Technique and Dyspnea in Weaning Patients
This is a randomized, controlled, multicenter, open-label, category 2, parallel-arm study of efficacy and superiority. The target population are patients hospitalized in the intensive care unit (ICU), ventilated with invasive…
- Conditions
- Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial, Dyspnea
- Trial name
- Easy Wean (NCT06926231)
- Testing
- Protocolized medical hypnosis, Protocolized standard of care
- Where
- 5 sites in France
- Volunteers
- 82 people
- Sponsor
- Hospices Civils de Lyon
Difficult-to-Wean Patients
Electrical Impedance Tomography in Guiding Early and Precise Rehabilitation of Patients with Difficult Ventilator Weaning
Diaphragm dysfunction, ineffective chest wall and respiratory muscle function are frequently observed in critically ill patients with difficult weaning from mechanical ventilation(MV).It is the leading cause of retention of…
- Trial name
- NCT06677099
- Testing
- chest physiotherapy, EIT-guided chest physiotherapy
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Respiratory Failure
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
- Trial name
- PNF techniques (NCT06831201)
- Testing
- Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Respiratory Failure, Osteopathy in Diseases Classified Elsewhere
The Utility of Osteopathic Manipulative Medicine in Weaning Patients from the Ventilator Pilot Trial
The objectives of this research are to determine the treatment effect size of OMM to wean patients off of the ventilator, determine the number of patients needed for a larger study (power), determine the willingness of…
- Trial name
- NCT06891248
- Testing
- Osteopathic Manipulative Treatment
- Volunteers
- 20 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Mechanical Ventilation
The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation
This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the…
- Trial name
- NCT07235956
- Testing
- Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.
- Volunteers
- 100 people
- Sponsor
- Zheng Qingjiang
Septic Shock
Weaning Approaches for Vasopressin in Sepsis
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
- Trial name
- WAVES (NCT07067866)
- Testing
- Titrated weaning of vasopressin., Abrupt weaning of vasopressin.
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Neonatal Respiratory Failure
Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange.
- Trial name
- Flow&Grow (NCT06123143)
- Testing
- Standardized/structured CPAP weaning protocol
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Icu
Functional Inspiratory Versus Expiratory Muscle Electrical Stimulation on Weaning Outcomes in Mechanically Ventilated Patients
The Goal of This Clinical Trail is To find out the difference in the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on weaning outcomes mechanically…
- Trial name
- NCT07204821
- Testing
- Inspiratory muscle functional electrical stimulation by Flexistem Digital electrical muscle stimulator, Expiratory muscle functional electrical stimulation by Flexistem Digital electrical muscle stimulator, Early rehabilitation program
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Beni-Suef University
Acute Kidney Injury
PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin
The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and…
- Trial name
- PRESSING (NCT06714214)
- Where
- 3 sites in Italy
- Volunteers
- 152 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Mechanical Ventilation Complication, Pulmonary Edema
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
- Trial name
- SystoWean (NCT05226247)
- Testing
- Spontaneous breathing trial
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
ARDS (Acute Respiratory Distress Syndrome)
Free for Weaning ECMO vs Respiratory Driven Study
In its most severe form, Acute Respiratory Distress Syndrome (ARDS) may require the use of veno-venous ECMO (vvECMO). While the criteria for vvECMO indication, ECMO settings, and ventilator management are relatively well-defined…
- Trial name
- FORWARD (NCT06876415)
- Testing
- P0.1 and delta Poeso integration into the decanulation decision
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pneumonia, Invasive Mechanical Ventilation
Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients
Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning).
- Conditions
- Pneumonia, Invasive Mechanical Ventilation, Weaning From Mechanical Ventilation in Care Unit, Respiratory Muscle Dysfunction
- Trial name
- NCT07405567
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Shock, Critical Illness
Enteral Versus Parenteral Nutrition During Recovery After Shock
This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.
- Conditions
- Shock, Critical Illness, Nutritional Support, Vasopressor Therapy
- Trial name
- NCT07411014
- Testing
- enteral nutrition, Parenteral Nutrition
- Where
- South Korea
- Volunteers
- 1,150 people
- Sponsor
- Samsung Medical Center