Clinical trials: Weaning Mechanical Ventilation
Ventilatory Failure
Individualised Weaning From Mechanical Ventilation in General ICU
Patients residing in the intensive care unit typically receive mechanical ventilatory support. Selecting the appropriate level of mechanical ventilation is not trivial, and it has been shown that lung protective settings can…
- Trial name
- iCareWean_CW (NCT03249623)
- Testing
- Beacon Caresystem
- Where
- United Kingdom
- Volunteers
- 274 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Mechanical Ventilation
Calorimetry Guided Nutrition vs. Recommended Daily Intake in Weaning Chronically Ventilated Patients: Double Blind RCT.
In this study, we intend to examine the effectiveness of an indirect calorimetry-guided nutrition plan, compared to the conventional, RDI-guided nutrition plan in mechanically ventilated patients, in terms of success rates of…
- Trial name
- NCT04825717
- Testing
- Nutrition and fluid plans prepared using calorimetry-based measurements.
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Reuth Rehabilitation Hospital
Thoracic Fluid Content, Electrical Cardiometry
Thoracic Fluid Content by Electrical Cardiometry Versus Lung Ultrasound in Mechanically Ventilated Patients
This study aims to compare the accuracy of the total thoracic fluid content (TFC) measured by electrical cardiometry with accuracy of lung ultrasound score in prediction of weaning outcome in mechanically ventilated patients.
- Conditions
- Thoracic Fluid Content, Electrical Cardiometry, Lung Ultrasound, Mechanical Ventilation
- Trial name
- NCT05272982
- Testing
- Thoracic fluid content by electrical cardiometry group, Ultrasound examination group
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Tanta University
Intubation, Extubation
Predictors Of Successful Extubation in Critically Ill Patients: Multicentre Observational Study
Extubation failure can directly worsen patient outcomes. Therefore, the decision to extubate is a critical moment during an intensive care unit (ICU) stay.
- Conditions
- Intubation, Extubation, Weaning, Mechanical Ventilation
- Trial name
- POSE (NCT03185962)
- Where
- Japan
- Volunteers
- 499 people
- Sponsor
- Osaka University
Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients
Evaluation of the Clinical and Prognostic Value of Non-invasive Analysis of Mandibular Movements (MM) as a Marker of Inspiratory Effort in the Spontaneously Breathing Intensive Care Patient
Evaluate the performance for measuring inspiratory effort of non-invasive mandibular movement analysis compared to the reference technique oesophageal pressure (PES) variation, in ventilated and spontaneously breathing Intensive…
- Conditions
- Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients, Invasive Mechanical Ventilation
- Trial name
- MM-ICU (NCT07441590)
- Testing
- 2 recording phases
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Weaning From Mechanical Ventilation
Effect of Adding PNF to IMT on Weaning Off MV
the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation.
- Trial name
- PNF/IMT/MV (NCT07536347)
- Testing
- threshold inspiratory muscle training + conventional chest physiotherapy, proprioceptive neuromuscular facilitation + threshold inspiratory muscle training + conventional chest physiotherapy, Conventional Chest Physiotherapy
- Volunteers
- 93 people
- Sponsor
- Beni-Suef University
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Diaphragmatic Ultrasound in Weaning
Diaphragmatic Ultrasound as a Guide Tool During Weaning From Mechanical Ventilation
To assess value of adding ultrasound derived variables to the usual parameters on success rate of weaning from mechanical ventilation in critically ill patients and to validate sensitivity and specificity of ultrasound derived…
- Trial name
- NCT03608332
- Testing
- diaphragmatic ultrasound
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Critical Care, Weaning From Mechanical Ventilation
Lung Aeration During WEANing From Mechanical Ventilation Determined by Electrical Impedance Tomography and Lung Ultrasound
Evaluation of lung aeration during weaning from mechanical ventilation determined by electrical impedance tomography and lung ultrasound
- Conditions
- Critical Care, Weaning From Mechanical Ventilation, Electrical Impedance Tomography, End Expiratory Lung Volume
- Trial name
- IWEAN (NCT02361021)
- Testing
- - Weaning from mechanical ventilation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myocardial Ischaemia During Surgery
Monitoring of Heart to Guide Myocardial Injury Patients to Wean From Ventilation
The goal of this prospective randomized controlled clinical trail is to explore the value of integrating continuous cardiac index variability indicators with existing weaning standards to guide perioperative myocardial injury…
- Trial name
- NCT06240104
- Testing
- cardiac output index monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Weaning Failure of Mechanical Ventilation
Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult…
- Trial name
- NCT07075926
- Testing
- Echocardiographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Mechanical Ventilation Weaning, Weaning Failure
Comprehensive Ultrasound Evaluation as a Predictor of Weaning
Several studies investigated the role of specific clinical predictors of weaning success, but it is determined by a combination of different aspects that can result in success or failure.
- Trial name
- NCT05539599
- Testing
- Comprehensive evaluation
- Where
- 2 sites in Italy
- Volunteers
- 89 people
- Sponsor
- Università degli Studi di Ferrara
Prolonged Mechanical Ventilation
Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the…
- Trial name
- NCT05634135
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Weaning Failure
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function
Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage.
- Trial name
- NCT03894189
- Testing
- Doxapram Hydrochloride, Theophylline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Beni-Suef University
Acute Respiratory Failure
Third International Study on Mechanical Ventilation
The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1.
- Trial name
- ISMV (NCT01093482)
- Where
- 477 sites in United States, Argentina and 36 more
- Volunteers
- 8,151 people
- Sponsor
- Hospital Universitario Getafe
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Weaning Failure, Mechanical Ventilation Complication
Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventilation
Weaning from mechanical ventilation (MV) is a complex process in which patients are liberated from the ventilator. Prolongued weaning and weaning failure, defined as the need for reintubation, have different adverse effects…
- Trial name
- NCT04554095
- Testing
- Clinical data collection
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Weaning Failure
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.
- Trial name
- NCT01928277
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- University of Tromso
Mechanical Ventilation Complication, Weaning Failure
Preventing Failed Extubations
More than 300,00 people in the United States experience acute respiratory failure and require mechanical ventilation every year.
- Trial name
- PreFIX (NCT06301867)
- Testing
- Plateau Pressure
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Duke University