Clinical trials: Weaning Mechanical Ventilation
Laryngeal Edema
Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation
In ICU, ventilatory weaning failure is common, accounting for up to 25% of extubations. These failures are largely due to swallowing disorders and laryngeal edema. Edema prevalence in ICU varies between 4 and 37%.
- Trial name
- REVEAL (NCT05611437)
- Testing
- Ultrafast ultrasonography
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier du Havre
Mechanical Ventilation, Weaning From Mechanical Ventilation
Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning
optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences
- Conditions
- Mechanical Ventilation, Weaning From Mechanical Ventilation, Weaning Failure
- Trial name
- NCT07083128
- Testing
- Parasternal intercostal thickening
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Respiratory Failure
Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients
To evaluate and compare two methods of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD) where the extubation failed.
- Trial name
- NCT00355732
- Testing
- Weaning from mechanical ventilation
- Where
- 2 sites in Croatia
- Sponsor
- Dr. Josip Benčević General Hospital
Respiratory Failure
Performance of Neurally Adjusted Ventilatory Assist (NAVA) During Spontaneous Breathing Trial
The purpose of this study is to compare a new mode of mechanical ventilation (NAVA, or Neurally adjusted Ventilatory assist) with a traditional mode (Pressure Support ventilation) on its the ability to detect patients ready for…
- Trial name
- NCT01337271
- Testing
- SBT- PSV, SBT - NAVA
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Mechanical Ventilation Complication
Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients
Datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. In particular, the effect of different modalities of spontaneous breathing trials on respiratory effort has not been extensively…
- Trial name
- TWEEP (NCT03856424)
- Testing
- Modality 1, Modality 2, Modality 3
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Piquilloud Imboden Lise
Respiratory Failure
Noninvasive Positive Pressure Ventilation for Difficult Weaning in Tracheotomy Patients
The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively. The investigators randomly allocate the subjects into two groups. One group is weaned by traditional strategy.
- Trial name
- NCT01900990
- Testing
- Noninvasive ventilation weaning
- Where
- 2 sites in China
- Volunteers
- 32 people
- Sponsor
- Chongqing Medical University
Communication
Electrolarynx for Enabling Communication in the CHrOnically Critically Ill (EECCHO)
All critically ill patients receiving mechanical ventilation experience a period of inability to speak due to the need for cuffed endotracheal or tracheostomy tubes.
- Trial name
- EECCHO (NCT05604079)
- Testing
- Electrolarynx
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Michael Garron Hospital
Inadequate or Impaired Breathing Pattern or Ventilation
Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure
The purpose of this study is to determine whether helmet is effective as device for noninvasive positive pressure ventilation in the weaning from mechanical ventilation.
- Trial name
- NCT01322659
- Testing
- Helmet, Endotracheal tube
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Padova
Weaning From Mechanical Ventilation
Comparison of Weaning on Pressure Support vs. Proportional Assist Ventilation: A Pilot Study
The study hypothesis is that reducing patient-ventilator asynchrony will reduce time required to wean from mechanical ventilation.
- Trial name
- NCT01666054
- Testing
- PSV, PAV
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Respiratory Insufficiency
Effectiveness Inspirational Muscle Training
The long stay in mechanical ventilation can induce several complications, among them respiratory muscle weakness, this has been related to the duration of mechanical ventilation, delay and failure to wean, resulting in longer…
- Trial name
- IMTversusMV (NCT03758573)
- Testing
- Inspiratory Muscle Training (IMT), Intensive Physiotherapy (IPT)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do vale do São Francisco
Weaning Failure, Mechanical Ventilation
Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
Background: It is largely undocumented how long it takes to wean from invasive mechanical ventilation (IMV) with tracheostomy and to what extend these patients suffer from dyspnea or discomfort and how often sputum retention…
- Conditions
- Weaning Failure, Mechanical Ventilation, Patient-centered Care
- Trial name
- Wean-Trach (NCT05906888)
- Where
- 13 sites in Netherlands
- Volunteers
- 156 people
- Sponsor
- Henrik Endeman
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin
Withdrawal, Anxiety
Terminal Weaning of Mechanical Ventilation or Extubation in Anticipation of Death in the Intensive Care Unit
The purpose of the study is to assess the dying process in critically ill patients with decision to withdraw invasive mechanical ventilation in anticipation of death and to compare effects of extubation and those of terminal…
- Conditions
- Withdrawal, Anxiety, Depression, Posttraumatic Stress Disorder
- Trial name
- ARREVE (NCT01818895)
- Where
- 44 sites in France
- Volunteers
- 458 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Extubation
Weaning And Variability Evaluation (WAVE)
The purpose of this study is to determine if variability in heart and breathing rates can be used to predict successful weaning.
- Trial name
- WAVE (NCT01086995)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Ultrasonography, Mechanical Ventilation Weaning
The Use of Diaphragmatic Ultrasonography in Mechanical Ventilation Weaning Decision in COPD Patient
The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient.
- Conditions
- Ultrasonography, Mechanical Ventilation Weaning, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07082361
- Testing
- conventional clinical criteria of weaning from mechanical ventilation, conventional clinical criteria and ultrasonic criteria for weaning
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Tanta University
Mechanical Ventilation
Effect of Transition From Mechanical Ventilation to Spontaneous Breathing on Intraocular Pressure in ICU (VENT-IOP)
This prospective, single-center observational study aims to evaluate the acute effects of transitioning from mechanical ventilation to spontaneous breathing on intraocular pressure (IOP) in intensive care unit patients.
- Trial name
- VENT-IOP (NCT07188922)
- Testing
- Non-invasive intraocular pressure measurement during ventilator weaning Description: Intraocular pressure will be measured using a portable non-invasive tonometer before and after the transition from
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Sevim Şenol Karataş
Respiratory Failure, Mechanical Ventilation
Personalized Ultrasound-Guided External Diaphragm Pacing to Improve Outcomes in Invasive Mechanically Ventilated Patients
This study aims to explore whether personalized external diaphragm pacing (EDP) guided by real-time diaphragm ultrasound (DU) can improve outcomes for patients on invasive mechanical ventilation.
- Trial name
- NCT06609577
- Testing
- Diaphragm Ultrasound-Guided External Diaphragm Pacing
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Daishan Jiang
Respiratory Failure
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
- Trial name
- PNF techniques (NCT06831201)
- Testing
- Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Weaning of Mechanical Ventilation
Arterial Blood Gases in Weaning of Mechanical VEntilation
Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before…
- Trial name
- WAVE (NCT05801692)
- Testing
- Weaning of mechanical ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon