Clinical trials: Weight
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN)
This is a study of tirzepatide in Chinese participants without Type 2 Diabetes who have obesity or overweight. The main purpose is to learn more about how tirzepatide affects body weight.
- Conditions
- Obesity, Overweight, Metabolism and Nutrition Disorder
- Trial name
- SURMOUNT-CN (NCT05024032)
- Testing
- Tirzepatide
- Where
- 29 sites in China
- Volunteers
- 210 people
- Sponsor
- Eli Lilly and Company
Psoriasis, Atherosclerotic Cardiovascular Disease
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Background: Psoriasis causes chronic inflammation in the body. Researchers want to see if a kind of vitamin B3 dietary supplement can help. This might lead to more treatment options.
- Conditions
- Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia
- Trial name
- NCT04271735
- Testing
- Niagen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Multiple Sclerosis
A Pragmatic Trial of Dietary Programs in People With Multiple Sclerosis (MS)
This is a pragmatic, single-blinded randomized trial of improving adherence to dietary interventions in patients with MS who are receiving monthly natalizumab infusions.
- Trial name
- NCT02846558
- Testing
- Frequent Patient Interaction, Timing Restriction, LoseIt! Smartphone Application
- Volunteers
- 54 people
- Sponsor
- Johns Hopkins University
Obesity
Research Intervention to Support Healthy Eating and Exercise
The primary aim of this study is to test the efficacy of a behavioral economics intervention for weight loss in adults from economically disadvantaged backgrounds.
- Trial name
- RISE (NCT04353258)
- Testing
- Behavioral Economics intervention (BE mHealth), Standard mHealth intervention (mHealth)
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- University of Connecticut
Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity Disease
The main purpose of this study is to learn more about tirzepatide in participants with obesity disease. The study will also measure how Tirzepatide affects body weight with a low-calorie diet and increased physical activity.
- Trial name
- SURMOUNT-J (NCT04844918)
- Testing
- Tirzepatide
- Where
- 18 sites in Japan
- Volunteers
- 267 people
- Sponsor
- Eli Lilly and Company
Impaired Fasting Glucose
The Effect of a Nutritional Supplement on Post Prandial Glucose and Lipids in an Adult Population
The primary aim of this study is to evaluate the effect of a fibre rich health food drink on the post prandial glucose and triglyceride peak in healthy overweight adults with impaired fasting glucose (IFG).
- Trial name
- NCT02119325
- Testing
- 25% fibre, 0% fibre
- Where
- India
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non-alcoholic Fatty Liver Disease, Obesity
A Study to Test How Well Different Doses of BI 3006337 Are Tolerated by People With Overweight or Obesity and With Fatty Liver Disease
This study is open to adults with overweight or obesity who also have fatty liver disease. The purpose of this study is to find the highest dose of BI 3006337 that people with overweight or obesity and with fatty liver disease…
- Trial name
- NCT05970640
- Testing
- BI 3006337
- Where
- 12 sites in United States
- Volunteers
- 64 people
- Sponsor
- Boehringer Ingelheim
Polycystic Ovary Syndrome, Metabolic Syndrome
Metabolic Syndrome in PCOS: Precursors and Interventions
The purpose of this study is to investigate the metabolic effects of anti-androgens and oral contraceptive pills (OCPs), compared with placebo, in the treatment of women with PCOS.
- Trial name
- NCT00442689
- Testing
- flutamide, ethinyl estradiol 35 mcg and drospirenone 3 mg
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Northwestern University
Cardiovascular Diseases, Cardiovascular Risk Factor
Cooking for Health Optimization With Patients
Cooking for Health Optimization with Patients (CHOP) is the first known multi-site prospective cohort study with a nested Bayesian adaptive randomized trial in the preventive cardiology field of culinary medicine.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Nutrition Disorders, Diabetes
- Trial name
- CHOP (NCT03443635)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 7,192 people, healthy volunteers welcome
- Sponsor
- Tulane University
Morbid Obesity
McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients
Our goal is to compare conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for endotracheal intubation in very morbidly obese patients undergoing non-cardiac surgery.
- Trial name
- NCT03467048
- Testing
- McGrath videolaryngoscopy, Direct laryngoscopy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Bullying, Weight, Body
Cognitive-Behavioral Therapy for Weight-related Bullying (Online Treatment)
This study will perform a clinical trial with adolescents to pilot a new cognitive-behavioral treatment (CBT) for weight-related bullying testing (1) feasibility, (2) acceptability, and (3) initial efficacy.
- Conditions
- Bullying, Weight, Body, Trauma, Psychological
- Trial name
- NCT04587752
- Testing
- CBT for Weight Bullying
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Cardiovascular Diseases, Diabetes Mellitus
Evaluation of a Letter Intervention Promoting a Plant-based Diet
The researchers' mission is to promote healthier eating behavior and to reduce costs associated with healthcare. The purpose of this study is to evaluate the effects of mailing randomly selected participants a letter promoting a…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Obesity
- Trial name
- NCT03880838
- Testing
- Personal testimonial, Forks Over Knives Documentary, Commitment nudge
- Where
- United States
- Volunteers
- 11,234 people
- Sponsor
- Geisinger Clinic
Obesity
Exenatide in Extreme Pediatric Obesity
Extreme pediatric obesity, the fastest growing category of obesity in youth, is associated with high risk for developing cardiovascular disease (CVD) and type 2 diabetes (T2DM).
- Trial name
- NCT01237197
- Testing
- Exenatide
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Minnesota
Pediatric Obesity, Meal Timing
Impact of Meal Timing on Glycemic Profile in Latino Adolescents With Obesity
In adolescents, conventional obesity treatment comprehensively addresses nutritional, activity, and behavioral topics. Due to limited resources in historically marginalized communities, implementation of nutrition-based…
- Trial name
- NCT05391438
- Testing
- Meal-timing
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's Hospital Los Angeles
Obesity, Inflammation
Effects of DHA on Pro-resolving Anti-inflammatory Mediators in Obese Patients Undergoing Weight-loss Treatment
Comparative, randomized, placebo-controlled, single-centre, single-blind clinical trial to assess the effectiveness of providing additional DHA omega-3 fatty acids supplements to increase the levels of pro-resolving and…
- Trial name
- NCT01865448
- Testing
- Omega-3 DHA
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Protein Supplies SL
Obesity
Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults
Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and…
- Trial name
- NCT00572624
- Testing
- Diet, Gastric bypass surgery
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus (T2DM)
Multiple Dose Study Of PF-05231023 In Obese Adult Subjects
This is a trial in obese subjects to study the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple doses of PF-05231023.
- Trial name
- NCT01923389
- Testing
- 100 mg PF-05231023
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Pfizer
Obesity, Type 2 Diabetes Mellitus
Effects of Obesity Treatments on Food Preferences and Metabolism
Obesity and Type 2 Diabetes Mellitus are major health problems which are becoming a burden both for patients and health systems alike.
- Trial name
- FPS (NCT01724060)
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Overweight
Physical Exercise Influence Among Overweight and Obese Pregnant Women
Objective: To evaluate the association between physical exercise for obese or overweight women and the maternal, perinatal outcomes and perception of these women about their quality of life.
- Trial name
- NCT01136291
- Testing
- physical exercise
- Where
- 2 sites in Brazil
- Volunteers
- 82 people
- Sponsor
- University of Campinas, Brazil
Metabolic Syndrome, Morbid Obesity
Omentectomy and Metabolic Syndrome
The aim of the present study was to evaluate the additional effect of sudden visceral fat reduction by omentectomy on Metabolic Syndrome, acute phase reactants and inflammatory mediators in patients with morbid obesity undergoing…
- Trial name
- NCT00923260
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass, Omentectomy
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
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