Clinical trials: Weight Changes, Body
Overweight, Obesity
Safety and Efficacy of Litramine in Overweight and Obese Subjects
Preparations that bind to nutritional fat and inhibit its absorption could be decisively meaningful for the regulation of bodyweight or obesity.
- Conditions
- Overweight, Obesity, Weight Loss
- Trial name
- NCT01233349
- Testing
- Litramine
- Where
- Germany
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Overweight or Obese Adults, Overweight or Obese, Type 2 Diabetes
Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D
A Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants with or without Type 2 Diabetes
- Trial name
- NCT07399678
- Testing
- ALV-100
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Alveus Therapeutics, Inc.
Metabolic Syndrome, Obesity & Overweight
Evaluating the SWW Method Dietary Intervention for HbA1c and Weight Management as a Preventative Intervention in Women
This study evaluated the SWW Method®, a 12-week dietary and lifestyle intervention based on the carbohydrate-insulin model, in a healthy cohort of women aged 35-75.
- Conditions
- Metabolic Syndrome, Obesity & Overweight, Blood Glucose Monitoring, Type 2 Diabetes Prevention
- Trial name
- NCT07463417
- Testing
- SWW Method® Dietary and Lifestyle Intervention
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Sarah Wragge Wellness
Cachexia
A Phase 1 Study of AV-380 in Healthy Subjects
This double-blinded, placebo-controlled, single ascending dose (SAD) study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity in healthy subjects of a single dose of AV-380.
- Trial name
- NCT04815551
- Testing
- AV-380
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- AVEO Pharmaceuticals, Inc.
Obesity, Obesity, Abdominal
Vestibular Stimulation to Trigger Adipose Loss Clinical Trial
There is an ongoing and worsening problem with obesity in the developed, and much of the developing world. Although it has long been realized that Western diets that are rich in sugar and fat play an important role in this, it…
- Conditions
- Obesity, Obesity, Abdominal, Metabolic Syndrome, Weight Loss
- Trial name
- VeSTAL (NCT03138369)
- Testing
- Vestibular nerve stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Neurovalens Ltd.
Pre-diabetes, Diabetes
Multi-Channel Automated Diet and Physical Activity Intervention for Pre-Diabetics
The trial will test whether the Alive multi-channel delivery health behavior program can positively affect weight and glucose level in pre-diabetics.
- Conditions
- Pre-diabetes, Diabetes, Obesity
- Trial name
- NCT01479062
- Testing
- Alive-PD, Usual Care
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Berkeley Analytics, Inc.
Obesity
Study to Assess Safety, Tolerability and Efficacy of SC Administered MBL949 in Obese Participants With or Without T2DM
This was a multi-center, randomized, placebo-controlled, participant-and-investigator-blinded, sponsor open-label study in obese participants with or without Type 2 Diabetes Mellitus.
- Trial name
- NCT05199090
- Testing
- MBL949
- Where
- 4 sites in United States
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
A Study to Determine the Effects of TM30339 on Weight Loss in Obese Individuals.
The purpose of this study is to determine the effects of TM30339 on weight loss in obese individuals after 28 days dosing.
- Trial name
- NCT00746824
- Volunteers
- 192 people
- Sponsor
- 7TM Pharma A/S
Obesity
Safety Study of the Inhibition of Agouti-related Protein (AgRP) for the Management of Obesity and Weight Loss
Multiple pathways including peripheral and central hormones and neurotransmitters are involved in the regulation of food intake and body weight. One of the most studied pathways involves the melanocortin receptor.
- Trial name
- NCT00779519
- Testing
- TTP435
- Where
- 12 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- vTv Therapeutics
Obesity
The ePass Clinical Trial for the Treatment of Obese Subjects
To evaluate the safety and efficacy of the endoscopically implanted ValenTx EndoPass™ System for treatment of adults with severe obesity.
- Trial name
- ePass (NCT02954016)
- Testing
- ePass
- Where
- 2 sites in Argentina, Mexico
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ValenTx, Inc.
Energy Expenditure, Appetite
Evaluation of Metabolism-Boosting Beverages
The purpose of this study is to assess the effect of Metabolism-boosting Beverages (MBB) containing green tea extract with a standardized amount of epigallocatechin gallate (EGCG) and caffeine.
- Trial name
- NCT01029236
- Testing
- Medifast Metabolism-boosting Beverages
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medifast, Inc.
Weight Loss
Litramine for Weight Loss
Safety and Efficacy of Litramine in weight loss.
- Trial name
- NCT02488356
- Testing
- Litramine
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Weight Gain
Growth Study Using Else Toddler Nutritional Drink vs. a. Dairy Based Toddler Drink (Control) in Healthy Toddlers
The aim of the study is to investigate the growth of healthy toddlers fed with Toddler almond based nutritional drink (test) vs. a. formula that has been shown to support growth (control) in Healthy Toddlers
- Trial name
- NCT05576870
- Testing
- Plant based toddler nutrition, Dairy based toddler nutrition
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Else Nutrition GH Ltd
Obesity
Safety & Tolerability of a Combination of Antidepressant and Peptic Ulcer Drug in Overweight Healthy Subjects
The hypothesis of this study is that up to 150 mg of sertraline and up to 3 mg of telenzepine will be safe, tolerable, and have the effect of suppressing appetite, when taken in combination daily by mouth by healthy, overweight…
- Trial name
- NCT01155531
- Testing
- Sertraline plus Telenzepine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Theracos
Anorexia, Cachexia
The Safety and Effectiveness of Megace in HIV-Infected Women
To further evaluate the safety of megestrol acetate (Megace) oral suspension in the treatment of anorexia and cachexia in HIV-positive women.
- Conditions
- Anorexia, Cachexia, HIV Infections
- Trial name
- NCT00002345
- Testing
- Megestrol acetate
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Bristol-Myers Squibb
Food Cravings
EXOMIND (BTL-699) for the Reduction of Food Cravings
The goal of this clinical trial is to evaluate if the treatment with BTL-699 device is able to temporarily reduce food cravings in adults above the age of 22 years.
- Trial name
- NCT06889298
- Testing
- Treatment with BTL-699
- Where
- Czechia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Weight Loss
OverStitch NXT Endoscopic Suture System
To demonstrate the safety and efficacy of OverStitch NXT Endoscopic Suture System for endoscopic sleeve gastroplasty（ESG） in obese populations to support the registration of OverStitch NXT for ESG indication.
- Trial name
- NCT07276815
- Testing
- OverStitch NXT Endoscopic Suture System
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Boston Scientific Corporation
Obesity, Overweight
Effect of Orlistat in Body Composition
The purpose of this study is to determine if a 24 week weight loss program with orlistat 60 mg will produce greater changes in body composition compared to placebo.
- Trial name
- NCT00752726
- Testing
- Orlistat
- Where
- 3 sites in United States, Sweden
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Overweight
A Study to Learn About the Study Medicine Called PF-08653944 Taken Once-Monthly Compared to Placebo in Chinese Adults With Overweight or Obesity
Overweight and obesity are long-term health conditions that can increase the possibility of serious health problems. These problems include heart disease, type 2 diabetes (a condition that causes high blood sugar), and other…
- Trial name
- NCT07874633
- Testing
- Berobenatide
- Where
- 2 sites in China
- Volunteers
- 432 people
- Sponsor
- Pfizer
Diabetes Type 2, Diabetes
Study Evaluating the Metabolic Effects of pulsENDO Therapy in Adults With Type 2 Diabetes
This is a prospective, multicenter, randomized, double-blind, sham-controlled, adaptive study evaluating the pulsENDO system in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering…
- Conditions
- Diabetes Type 2, Diabetes, Diabetes (DM), Weight Change
- Trial name
- pulsENDO (NCT07768631)
- Testing
- pulsENDO Therapy
- Volunteers
- 320 people
- Sponsor
- Endogenex, Inc.