Clinical trials: Weight Changes, Body
Diabetic Kidney Disease, Cognitive Function
Metabolism of Low Carbohydrate and Ketogenic Diet
This study will assess the preliminary efficacy of a lifestyle intervention including low-carb/ketogenic diet and exercise, enhanced by self-monitoring through health technologies on weight and diabetes outcomes (Glucose, HbA1c)…
- Conditions
- Diabetic Kidney Disease, Cognitive Function, Weight Loss, Diabetic Control
- Trial name
- NCT05071287
- Testing
- mHealth + low-fat diet, mHealth + low-carb/ketogenic diet
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Weight Loss
Financial Coaching and Lifestyle Intervention for Diabetes Prevention in Low-income Families
The purpose of this study is to compare the effect on weight and metabolic outcomes of an enhanced intervention, comprised of evidence-based financial coaching plus a lifestyle intervention vs. the lifestyle intervention alone
- Trial name
- NCT05944549
- Testing
- Financial coaching using TrustPlus, Brighter Bites, Noom
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity, Overweight
A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults
This was a dose-finding study that evaluated the change in weight after 24 weeks treatment with 8 different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24 weeks treatment with 2 doses of LIK066…
- Trial name
- NCT03100058
- Testing
- LIK066
- Where
- 83 sites in United States, Austria and 5 more
- Volunteers
- 460 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure With Reduced Ejection Fraction, Obesity
Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
The benefit of weight loss in patients with obesity and heart failure with reduced ejection fraction (HFrEF) is controversial. Semaglutide has shown cardiovascular (CV) risk-reduction and impact on CV risk factors including…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Obesity, Weight Loss, Chronic Heart Failure
- Trial name
- FIT-HF (NCT06423599)
- Testing
- Semaglutide Injectable Product, Calorie-restricted diet
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Jens D Hove, MD,PHD
Weight, Blood Pressure
Interactive Web Program and Health Coaching for Prehypertensive Adults
This project will develop and evaluate an interactive blood pressure self-management program for adults with prehypertension. The program will target blood pressure self-monitoring and the five proven lifestyle modifications…
- Trial name
- Prehype (NCT02637063)
- Testing
- BlipHub mobile-web app, BlipHub mobile-web app + health coaching, Usual care
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Oregon Center for Applied Science, Inc.
Weight Loss, Postpartum Weight Retention
Weight Loss and Physical Fitness Following Pregnancy in Active Duty Women
Pregnancy and delivery are major stressors on the female body and contribute significantly to permanent weight gain and associated morbidity in women.
- Trial name
- PADaWL (NCT05518604)
- Testing
- Counseling with goal of modifying eating behaviors
- Where
- 2 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Tripler Army Medical Center
Overweight and Obesity
The Lean Living Study
This study investigates whether walnuts help to promote weight loss, associated with increased meal satiety and satisfaction, in 100 overweight and obese men and women who are participating in a 6-month behavioral weight loss…
- Trial name
- NCT02501889
- Testing
- Walnut-rich weight loss diet, Standard weight loss diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Diastolic Dysfunction
Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.
- Conditions
- Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07565610
- Volunteers
- 150 people
- Sponsor
- Itshak Amsalem
Morbid Obesity, Weight Loss
Intraoperative Measuring of Small Bowel Length Compared to Measuring by Magnetic Resonance Imaging (MRI) in Morbid Obese Patients
An important step during a gastric bypass operation for the treatment of morbid obesity is the measuring of the small bowel length.
- Trial name
- NCT00740662
- Testing
- Distal gastric bypass
- Where
- 2 sites in Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Advanced COPD (GOLD Stage 3 or 4) With Cachexia
Efficacy of Serum Bovine Immunoglobulin in Improving Nutritional Status in Advanced COPD
This study will evaluate the use of a medical food, oral serum-derived bovine immunoglobulin/protein isolate (SBI), in helping patients with advanced COPD with cachexia (a wasting syndrome) improve their nutritional status and…
- Trial name
- SBI for COPD (NCT02067377)
- Testing
- Serum bovine immunoglobulin (SBI) medical food
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Obesity
Energy Balance Weight Regulation Study
The purpose of this study is to test the hypothesis that a low-carbohydrate diet will impact hormones and other factors that regulate appetite and energy balance, and result in lower energy intake and greater weight loss, than a…
- Trial name
- BALANCE (NCT00619008)
- Testing
- Ad libitum low carbohydrate diet, Ad libitum High Complex Carbohydrate Diet, Energy-restricted high complex carbohydrate diet
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Obesity, Weight Gain
Exercise, Brain Activity, and Weight Maintenance
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
- Conditions
- Obesity, Weight Gain, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- NCT06511310
- Testing
- Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity
Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years
This study will be conducted to demonstrate weight loss efficacy by change in body mass index (BMI) and safety in adolescents age 12 to 17 years (inclusive) during 52 weeks of treatment with Belviq XR 20 milligrams (mg)…
- Trial name
- NCT03338296
- Testing
- lorcaserin hydrochloride XR
- Where
- 16 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Overweight and Obesity
A Study to Evaluate the Adjustment Function of a Modified Spatz3 Adjustable Balloon (Spatz4).
The purpose of this study is to evaluate the function of the adjustment procedure with the Spatz4 in subjects with a BMI ≥ 27.
- Trial name
- NCT06373666
- Testing
- Spatz4 Adjustable Balloon System
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Spatz FGIA, Inc
Obesity & Overweight, Obesity (Disorder)
Optimizing Self-Monitoring Feedback Delivery for the Treatment of Overweight and Obesity
The purpose of this research study is to learn how to best provide weekly feedback on individual progress toward intervention goals during a weight loss program.
- Trial name
- NCT07227051
- Testing
- Feedback on Calorie Goal Attainment, Feedback on Dietary Quality, Feedback on Physical Activity Goal Attainment
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Overweight, Obesity
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks.
- Trial name
- NCT06325722
- Testing
- Low-carbohydrate Diet, Low-fat Diet
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Amyotrophic Lateral Sclerosis (ALS)
Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is an adult neurodegenerative disease that is caused by a selective degeneration of the motor nerve cells in the cortex and myelon.
- Trial name
- NCT00876772
- Testing
- Olanzapine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes
Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction
There is an epidemic of type 2 diabetes in younger adults. These patients are at very high lifetime risk of heart-related complications.
- Trial name
- Diastolic (NCT02590822)
- Testing
- Cambridge Weight Plan, Supervised Exercise Sessions
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Weight Loss
A Social-networking-site(SNS) Based Weight Loss Behavior Intervention- the Effect of Social Network and Multi-level Factors on Weight Loss
In this project, investigators plan to conduct a randomized control trial of a weight loss intervention that is remotely delivered via SNS among the obese adult patients (20-64 years old, BMI ≥ 27 kg/m2) recruited from weight…
- Trial name
- NCT06237933
- Testing
- Enhanced intervention via social networking site (SNS), Standard intervention
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Weight Change, Body, Stroke
The Effect of Body Mass Index (BMI) on Inpatient Stroke Rehabilitation Outcome: A Prospective Study From an East-Asian Cohort
Research has shown that rehabilitation at almost any Body Mass Index (BMI) level leads to positive functional outcomes. Some data demonstrating that gains are often more rapid at BMI above "normal".
- Trial name
- NCT04625933
- Testing
- No intervention
- Where
- Singapore
- Volunteers
- 247 people
- Sponsor
- Tan Tock Seng Hospital
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