Clinical trials: Weight Changes, Body
Melanocortin Obesity Syndrome, MCOS
Atomoxetine in Melanocortin Obesity Syndrome
This is a phase 2 randomized placebo-controlled crossover trial to determine the safety and efficacy of atomoxetine for treating obesity caused by loss-of-function variants in the melanocortin-4 receptor (MC4R), the most common…
- Trial name
- MCOS (NCT06899178)
- Testing
- Atomoxetine
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Liver Disease Parenchymal
Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery
Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.
- Trial name
- NCT06372015
- Testing
- Nutritional Approach, Surgery Approach
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Severe Obesity
Effect of Nutritional Intervention and Olive Oil in Severe Obesity
Obesity is a worldwide epidemic with increasing prevalence, specially severe obesity (Body Mass Index (BMI) ≥ 35 kg/m2). It is a multifactorial disease that involves genetic and environmental factors that lead to increased…
- Trial name
- NCT02463435
- Testing
- Nutritional intervention, Nutritional intervention plus olive oil, Olive oil
- Where
- Brazil
- Volunteers
- 229 people
- Sponsor
- Universidade Federal de Goias
Liver Transplantation, Metabolic Syndrome X
Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients
Many metabolic complications can develop after liver transplant including: diabetes, high blood pressure, obesity, heart attacks and stroke.
- Conditions
- Liver Transplantation, Metabolic Syndrome X, Obesity
- Trial name
- NCT02174783
- Testing
- Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Diabetes, Weightloss
The WISE (Weightloss Intervention Surgical Effects) Brain Study
This study is being done to learn about the changes that weight loss causes on brain function, memory and thinking ability in adults. The study does NOT cover any costs associated with bariatric surgery.
- Trial name
- WISEBrain (NCT02137070)
- Testing
- Bariatric Surgery Candidates, Non surgical/Community volunteers
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stunting, Wasting
Impact Evaluation of Benazir Nashonuma Program (BNP) on Stunting Among Under-five Children
The aim of the study is to evaluate the impact of Benazir Nashonuma Program (BNP) on prevalence of stunting among under-five children in low income setting of Pakistan.
- Conditions
- Stunting, Wasting, Anemia, Nutrient Deficiency
- Trial name
- NCT06025786
- Testing
- Benazir Nashonuma Program (BNP)
- Where
- Pakistan
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Weight Loss, Other Effects of High Altitude
Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization
This research will evaluate nutrition requirements for missions at high altitude (i.e. >7800 feet above sea level) and the information obtained can be used to optimize nutrient content specifications for combat rations.
- Trial name
- NCT02731066
- Testing
- Standard pro, High pro, carbo bev
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Overweight, Obesity
Hockey Fans in Training (Hockey FIT): Improving Men's Health Through the Power of Sport
Hockey Fans in Training (Hockey FIT) is a 12-month (3-month active phase and 9-month minimally-supported phase) weight loss and healthy lifestyle program for middle-aged, male hockey fans with overweight or obesity, delivered by…
- Trial name
- NCT03636282
- Testing
- Hockey FIT Program (Immediate Delivery)
- Where
- 40 sites in United States, Canada
- Volunteers
- 997 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Stroke
Cultural Modification of an Evidence Based Healthy Lifestyle Intervention for People Post Stroke Who Identify as Hispanic/Latino
The purpose of this trial is to examine weight loss for Hispanic/Latino people with stroke (CVA) who take part in a healthy lifestyle program that has been culturally modified for Hispanic/Latino people
- Trial name
- NCT06517459
- Testing
- Group Lifestyle Balance
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor Research Institute
PreDiabetes, Obesity
Promotora-Led Intervention for Metabolic and Mental Health
Evidence-based programs to prevent diabetes among high-risk individuals are less effective among those who also have mental health needs.
- Conditions
- PreDiabetes, Obesity, Metabolic Disease, Body Weight Changes
- Trial name
- PRIME2 (NCT03372018)
- Testing
- Promotora-led Intervention (PLI), Usual care (UC)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Advanced Cancer, Cachexia
Multimodal Treatment Strategy for Cancer Cachexia
The primary aim of this proposal is to present a novel, multimodal treatment strategy for increasing lean body mass in individuals with cancer who experience cachexia between baseline and day 29 (+/- 3 days).
- Trial name
- NCT00625742
- Testing
- Graded Resistance Training, Aerobic Exercise, Melatonin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Exclusive Breastfeeding, Feeding Patterns
SPOON: Sustained Program for Improving Nutrition - Mexico
The primary goal of this study is to assess the impact of an innovative strategy to prevent undernutrition and obesity in early childhood in children 0-24 months in Mexico.
- Conditions
- Exclusive Breastfeeding, Feeding Patterns, Stunting, Obesity, Childhood
- Trial name
- NCT03752762
- Testing
- SQ-LNS, SPOON behavioral change strategy
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Inter-American Development Bank
Glucagon-like Peptide-1, Smoking Cessation
Smoking Cessation Facilitated by Glucagon-like Peptide-1 (GLP-1) Analogues
Cigarette smoking is the leading preventable cause of premature death worldwide. However smoking is a very difficult addiction to break whereby main reasons for not quitting or relapsing after cessation are the nicotine…
- Conditions
- Glucagon-like Peptide-1, Smoking Cessation, Weight Change, Body, Craving
- Trial name
- SKIP (NCT03204396)
- Testing
- Dulaglutide, 0.5 ml normal saline (0.9% sodium chloride [0.9% NaCl])
- Where
- Switzerland
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Overweight
EMPOWER Rural Extension Weight Management Pilot Study
This research is to expand a virtual weight loss and weight maintenance program to rural counties of Illinois. The program uses dietary and lifestyle modifications for adults with obesity.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT05587790
- Testing
- Weight Management Intervention
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Illinois at Urbana-Champaign
Gestational Weight Gain
A Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight/Obese Women
The aim of this trial is to investigate the effectiveness of a mobile health (mhealth) intervention to help overweight and obese women achieve appropriate gestational weight gain (GWG) for their pre-pregnancy body mass index…
- Trial name
- NCT03880461
- Testing
- Lifestyle Intervention
- Where
- 4 sites in United States
- Volunteers
- 1,335 people
- Sponsor
- Kaiser Permanente
Non-small Cell Lung Cancer, Pancreatic Cancer
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
Study to compare the effects of the investigational new drug (PF-06946860) and a placebo on appetite and to find out how participants with advanced cancer and anorexia feel after receiving repeated subcutaneous (SC-injected under…
- Conditions
- Non-small Cell Lung Cancer, Pancreatic Cancer, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT04803305
- Testing
- PF-06946860
- Where
- 33 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- Pfizer
Erectile Dysfunction
Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: a Randomized Controlled Trial
Healthy lifestyle factors are associated with maintenance of erectile function in men. To determine the effect of weight loss and increased physical activity on erectile and endothelial functions in obese men.
- Trial name
- NCT00636688
- Testing
- Lifestyle - detailed advice, Control - general information
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Sensitivity to Thyroid Hormones, Metabolic Parameters
Effects of Intermittent Fasting on Fatty Liver Disease
Eighty subjects with FLD were recruited from the endocrinology clinic at Beijing Chao-yang Hospital. All of the following inclusion criteria needed to be met: hepatic fat content (HFC) were upper 5.0% evaluated by upper abdominal…
- Conditions
- Sensitivity to Thyroid Hormones, Metabolic Parameters, in Patients With FLD
- Trial name
- NCT04795973
- Testing
- 5:2 intermittent fasting
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Chao Yang Hospital
Overweight and Obesity, Diet Modification
Understanding Mechanisms of Health Behavior Change
This research seeks to examine psychological factors that may impact relationship between incentives and health behavior engagement, specifically fruit and vegetable consumption.
- Conditions
- Overweight and Obesity, Diet Modification, Incentives
- Trial name
- NCT03192254
- Testing
- self-monitoring, daily monetary incentives, delayed lump sum monetary incentives
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Weight Loss
Long-term Follow up After SG vs RYGB vs OAGB
A prospective randomized clinical study of all morbidly obese patients undergoing SG, RYGB and OAGB, as primary bariatric procedures, was performed.
- Trial name
- NCT03467646
- Testing
- Sleeve Gastrectomy, Roux-en-Y gastric bypass, One-Anastomosis Gastric Bypass
- Volunteers
- 600 people
- Sponsor
- Hospital General Universitario Elche
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