Clinical trials: Weight Loss, completed
Obesity
A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight
This study will look at how well CagriSema helps people with excess body weight lose weight. CagriSema is a new medicine developed by Novo Nordisk that combines cagrilintide and semaglutide.
- Trial name
- NCT06388187
- Testing
- Cagrilintide, Semaglutide
- Where
- 25 sites in United States, Canada and 3 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Overweight
Effectiveness of Changing Dietary Fat on Weight Loss
This study will compare two energy reduced diets; one diet will include one Haas avocado/day while the other diet will follow the usual American dietary pattern.
- Trial name
- HAWLS (NCT02953158)
- Testing
- Haas Avocado, Dietary Counseling
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
COPD, Cachexia
Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD Cachexia
SF-K002 is a pilot study in patients with moderate to severe COPD suffering from involuntary weight loss. The study is 12 weeks, double-blinded, placebo controlled and the main objective is to study the safety and tolerability of…
- Trial name
- NCT02442908
- Testing
- Nutrifriend Cachexia
- Where
- 4 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Smartfish AS
Overweight
Efficacy and Safety of Zenoctil in Reducing Body Weight
The intention of the study is to evaluate the safety and potential body weight and body fat loss effects of a 12-week treatment with Zenoctil in a randomized, double-blind, placebo-controlled, parallel study conducted in…
- Trial name
- NCT01423617
- Testing
- Zenoctil
- Where
- Germany
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Gastrointestinal Symptoms, Weight Loss
A Trial to Assess Gastrointestinal Responses to Dietary Fibers in Adults Using Weight Loss Medications
The objective of this study is to assess self-reported gastrointestinal (GI) responses to three snack bars containing fiber/fiber blends vs. a control snack bar for 7 days each in adults using GLP-1 agonists.
- Conditions
- Gastrointestinal Symptoms, Weight Loss, GLP-1
- Trial name
- NCT07012317
- Testing
- High Fiber Bar with Inulin, High Fiber bar with Fiber Blend, High Fiber Bar with Resistant Starch type 4
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Weight Loss Maintenance
Keep It Off: A Weight Loss Maintenance Study
The goal of this project is to test whether a phone and mail-based program designed to help people who have recently lost weight helps them keep the weight off over a 2 year period.
- Trial name
- KIO (NCT00702455)
- Testing
- Self-Directed (weight loss maintenance), Guided (weight loss maintenance)
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Serious Mental Illness
Coach to Fit Weight Loss Intervention for Individuals With Serious Mental Illness
This project addresses obesity in the population with SMI by evaluating a weight management program that is not only evidence-based, it is sustainable, transportable, appealing to patients, easy to use, and minimally burdensome…
- Trial name
- C2F (NCT04560335)
- Testing
- Coach to FIt, Treatment as Usual
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- VA Office of Research and Development
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Obesity
Safety and Efficacy of APD356 in the Treatment of Obesity
This is a research study of an investigational drug, APD356, a novel, selective 5-HT2c receptor agonist, in clinical development as a potential treatment for obesity.
- Trial name
- NCT00116740
- Testing
- APD356
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Overweight, Obese
Physical Activity and Health Outcomes
Obesity is common in adults with complex medical problems with ensuing complications afterwards. Obese patients suffer higher mortality and impaired functional status often as a result of their obesity.
- Trial name
- PAHO (NCT01833507)
- Testing
- Self-Exercise, Usual Care
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
POMC Deficiency Obesity, PCSK1 Deficiency Obesity
An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes
This is an observational study. There are no protocol-defined visits, although patients are expected to have routine office visits approximately every 6 months.
- Conditions
- POMC Deficiency Obesity, PCSK1 Deficiency Obesity, LEPR Deficiency Obesity
- Trial name
- NHS (NCT03621007)
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity, Overweight
Family Based Treatment for Weight Loss With Breakfast Prescription
The purpose of this study is to evaluate whether a behavioral weight loss group in conjunction with a prescribed breakfast can help children between 8 and 12 years of age change their behaviors to help them lose weight and become…
- Conditions
- Obesity, Overweight, Overeating, Weight
- Trial name
- FAB (NCT02467036)
- Testing
- Family Based Behavioral Treatment
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Weight Loss
Mother and Child Health Outcomes After Maternal Bariatric Surgery
Childhood obesity has been a growing problem with more than 30% of children between 6 and 19 years old being considered overweight or obese.
- Trial name
- NCT03297307
- Testing
- Presurgical Counseling
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Obesity
Reducing Snack Variety in Weight Loss Treatment
The rising prevalence of obesity in the United States is believed to be due to increased exposure to adverse environmental factors, such as food portion sizes and increased dietary variety.
- Trial name
- NCT00328744
- Testing
- Standard, Limited Variety
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Overweight and Obesity
Analysis of De-identified Data From Commercially-available App Lose It!
The study team analyzed de-identified user data provided by the commercial app Lose It!, an entity of FitNow, Inc.
- Trial name
- NCT03136692
- Testing
- Lose It! commercial weight loss app
- Volunteers
- 7,007 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Food Cravings
EXOMIND (BTL-699) for the Reduction of Food Cravings
The goal of this clinical trial is to evaluate if the treatment with BTL-699 device is able to temporarily reduce food cravings in adults above the age of 22 years.
- Trial name
- NCT06889298
- Testing
- Treatment with BTL-699
- Where
- Czechia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Overweight and Obese Adults, BMI >= 23
Dose Response of Leucine on Muscle Maintenance During Weight Loss
The objective of this research is to determine if there is dose response of leucine on muscle maintenance during 4-week of alternate-day fasting (ADF) on blood parameters, body composition, mood and parameters related to appetite…
- Trial name
- NCT07583875
- Testing
- leucine
- Where
- Singapore
- Volunteers
- 92 people
- Sponsor
- Nanyang Technological University
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Morbid Obesity
Effect of Long Biliopancreatic Limb RYGB on Weight Loss and Comorbidities
Morbid obesity is an increasing medical problem in the western countries. It's related to comorbidities as diabetes mellitus, hypertension, OSAS, arthrosis and hypercholesterolemia.
- Trial name
- Elegance (NCT01686997)
- Testing
- Roux-en-Y Gastric Bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- Rijnstate Hospital
Diabetes Mellitus, Obesity
A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss
This study compares two types of diet interventions: a low carbohydrate ketogenic diet (Atkins) and a low-fat diet combined with a medication (Orlistat).
- Trial name
- NCT00108524
- Testing
- Low carbohydrate ketogenic diet, Orlistat, Low-fat diet
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
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