Clinical trials: Weight Loss Trial
Bariatric Surgery, Morbid Obesity
The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery
Bariatric guidelines recommend preoperative weight loss of 5% to reduce the risk of surgical complications. However, results in the literature on the improvement of surgical procedure and outcomes are still conflicting.
- Trial name
- NCT04433338
- Testing
- 14-day Low Calorie Diet
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Rijnstate Hospital
Obese Adults
A Phase 1 Study of VK2735 in Obese Adults Without Comorbidities
The goal of this Phase 1, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of VK2735 in adults who are obese (BMI ≥ 30 kg/m2) without comorbidities.
- Trial name
- NCT07838740
- Testing
- VK2735 Drug
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Viking Therapeutics, Inc.
Obesity
Protein and Resistance Exercise to Stop Sarcopenic Obesity Now
The purpose of this study is to examine the separate and combined effects of a high-protein (HP) diet and resistance training (RT) on body composition and potential biological moderators of body weight in women and men >50y.
- Trial name
- PRESS ON (NCT04014296)
- Testing
- High Protein Diet Counseling, Resistance Training Counseling, Intensify Initial Intervention
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cancer-associated Cachexia
Visugromab in Cachexia International Trial
A study of how well and safely a new drug called visugromab works in people with certain kinds of cancer (including lung and bowel cancer) and unintended weight loss known as cachexia.
- Trial name
- VINCIT (NCT07112196)
- Testing
- Visugromab (CTL-002)
- Where
- 74 sites in United States, Bulgaria and 10 more
- Volunteers
- 518 people
- Sponsor
- CatalYm GmbH
Weight Loss
Feasibility Testing of Plant-Based Supplemented Food Products Made With Manitoba Crop Ingredients for Weight Loss
The purpose of this study is to advance the development of the WI/CDIC supplemented foods by evaluating the acceptance and feasibility of the supplemented food bars within the Wellness Institute's Weight Loss Clinic program (WLC)…
- Trial name
- NCT06614543
- Testing
- Supplemented Food
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Prediabetes, Obesity / Overweight
Very-Low-Carbohydrate Diet for Prediabetes and Obesity
Prediabetes is a condition where blood sugar is higher than normal but not yet high enough to be called type 2 diabetes. It is common in adults who are overweight or obese, and without treatment it often progresses to diabetes…
- Conditions
- Prediabetes, Obesity / Overweight, VERY LOW CARBOHYDRATE DIET
- Trial name
- VLCBD (NCT07830121)
- Testing
- Standard Dietary Advice, Very-Low-Carbohydrate Diet (VLCBD)
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- Universiti Teknologi Mara
Hidradenitis Suppurativa
Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or Obesity
This study will test an experimental Regeneron drug called olatorepatide ("study drug") to see if it can help treat Hidradenitis Suppurativa (HS).
- Trial name
- NCT07830329
- Testing
- Olatorepatide
- Volunteers
- 300 people
- Sponsor
- Regeneron Pharmaceuticals
Weight Reduction, Prediabetes
Georgia CEAL RESTORES Family Diabetes Study
The goal of this clinical trial is to determine whether a family-based lifestyle intervention reduces the risk of type 2 diabetes (T2D) among parents and their children.
- Trial name
- GA CEAL (NCT07808723)
- Testing
- Family Diabetes Prevention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Weight Loss, Blood Pressure
Feasibility & Implementation of a Plant-Based Weight-Loss Program in an Office-Based Setting
This prospective study aims to assess the feasibility and implementation of a plant-based, weight-loss program in an office setting.
- Conditions
- Weight Loss, Blood Pressure, Lipid Disorder, PreDiabetes
- Trial name
- NCT04091516
- Testing
- Low-fat plant-based diet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Type 2 Diabetes, Overweight and Obese Adults
Plant-Based Online Weight Loss Through Education and Resources Program and Study
This is an interventional study that will evaluate the feasibility, implementation, and efficacy of an online, 12-week, plant-based, nutrition education program in a community setting.
- Trial name
- POWER (NCT07095543)
- Testing
- Low-fat, vegan diet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Physicians Committee for Responsible Medicine
Overweight, Obesity
Weight and Metabolic Management Study
The goal of this clinical trial is to learn whether elénzia CONTROL®, a nutritional supplement, can support weight management in adults who have either never used GLP-1 weight-loss medications or have recently stopped using them.
- Conditions
- Overweight, Obesity, Weight Maintenance
- Trial name
- WMMS (NCT07789223)
- Testing
- elénzia CONTROL®
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Elenzia
Gout, Obesity (BMI>30)
Mazdutide for Weight Management and Gout in Adults With Obesity
This is a single-arm, open-label, pre-post controlled study to evaluate the effect of Mazdutide on the annualized flare rate (AFR) in adults with obesity and gout.
- Conditions
- Gout, Obesity (BMI>30), Hyperuricemia, Metabolic Syndrome
- Trial name
- NCT07824895
- Testing
- Mazdutide
- Volunteers
- 30 people
- Sponsor
- Hongwei Jiang
Obesity, Spine Condition
Longitudinal Changes in Spinopelvic Alignment and Sagittal Balance After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand how major weight loss after bariatric surgery may be associated with changes in the way the spine and pelvis are aligned in adults with morbid obesity.
- Trial name
- BARISPINOALIGN (NCT07794553)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Obese, Limb Deformities
Longitudinal Changes in Lower Extremity Alignment and Mechanical Axis Parameters After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand whether major weight loss after bariatric surgery is associated with changes in the alignment of the lower limbs in adults with morbid obesity.
- Conditions
- Obese, Limb Deformities, Arthritis
- Trial name
- BARILIMBSALIGN (NCT07794566)
- Testing
- Obese.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Unintended Weight Loss
Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combined With GRAIL Galleri Testing to Improve Early Detection
Unintentional weight loss (UWL) is commonly associated with a wide variety of diseases and there is still no valid diagnostic pathway for evaluating UWL.
- Trial name
- NCT05481697
- Testing
- GRAIL Galleri
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Case Comprehensive Cancer Center
Obesity and Obesity-related Medical Conditions
A Wearable Device and AI-Supported Diet and Exercise Intervention
This study implemented a personalized 6-month diet and exercise program to promote weight loss. Participants were recruited from outpatient clinics at the Department of Family Medicine, National Taiwan University Hospital.
- Trial name
- NCT06630663
- Testing
- A Wearable Device and AI-Supported Diet and Exercise intervention, standard care
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Obesity & Overweight, Weight Loss
A Prospective Cohort Study on Patient With Obesity Undergoing Weight Change
This prospective cohort study collected baseline data and followed up obese patients at their first visit to a weight loss clinic.
- Conditions
- Obesity & Overweight, Weight Loss, Metabolic Syndrome, Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07239167
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Diabetes, Obesity
Addressing Diabetes by Elevating Access to Nutrition
The goal of ADELANTE is to determine whether a multi-level intervention to improve household food insecurity and glycemic control is effective for Latino patients with diabetes. Specifically, ADELANTE aims to 1.
- Conditions
- Diabetes, Obesity, Lifestyle, Healthy
- Trial name
- ADELANTE (NCT05228860)
- Testing
- Vida Sana (a Group Lifestyle Intervention), Supplemental Healthy Food Deliveries
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Stanford University
Overweight , Obesity, Weight Loss
Retrospective Continuous Glucose Monitor (CGM) Study on Glycemic Response and Body Composition in College Students
This retrospective study evaluates the real-world effect of individualized glycemic response-guided dietary management, based on continuous glucose monitoring (CGM), on weight and body composition in overweight and obese…
- Trial name
- RCSOGRABCICS (NCT07818005)
- Where
- China
- Volunteers
- 59 people
- Sponsor
- He Eye Hospital