Clinical trials: Weight Reduction and Insulin Sensitivity
Body Composition, Fitness
Evaluation of Molecular Hydrogen Supplementation to Enhance the Efficacy of Weight Loss Retreat in Overweight and Obese Adolescents
This randomized controlled trial evaluates whether molecular hydrogen supplementation enhances the effectiveness of a 4-week weight loss retreat in overweight and obese adolescents.
- Conditions
- Body Composition, Fitness, Insulin Sensitivity, Lipid Profile
- Trial name
- NCT06961110
- Testing
- Hydrogen-rich water
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Palacky University
Type 2 Diabetes, Insulin Resistance
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity
- Trial name
- NCT00422253
- Testing
- dietary intervention
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks…
- Trial name
- NCT01452074
- Testing
- Exercise Training, Weight Loss with continued Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Body Fat
Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) in Human Obesity
The aim of the study is to analyze the effects of Lipoic acid and/or EPA supplementation on weight loss, lipid profile, insulin resistance, oxidative and inflammation parameters, metabolomic profile as well as on adipose tissue…
- Conditions
- Obesity, Body Fat, Insulin Resistance
- Trial name
- OBEPALIP (NCT01138774)
- Testing
- Double blind dietary intervention with EPA and lipoic acid
- Where
- Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance
Incretin mimetics are widely used pharmacological treatments for weight loss, known for their high efficacy and favorable safety profile.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Insulin Sensitivity/Resistance, Semaglutide
- Trial name
- TRIM-IR (NCT06856291)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- ETH Zurich
HIV Infections, Insulin Resistance
Diet, Exercise and/or Rosiglitazone for HIV-Associated Insulin Resistance
The purpose of this study is to determine if, in men and women with excess abdominal fat and insulin resistance, people with HIV infection respond differently than people without HIV to interventions that typically improve body…
- Conditions
- HIV Infections, Insulin Resistance, Obesity
- Trial name
- NCT00264251
- Testing
- Weight loss through diet and exercise, Rosiglitazone insulin sensitizing agent
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Obesity, Insulin Sensitivity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity.
- Conditions
- Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity
- Trial name
- NCT06129110
- Testing
- Diet Weight Loss
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Physical Activity and Food Intake Interaction: Effect of Weight Loss in Obese Adolescent
In obese adolescents, energy expenditure (EE) of chronic high intensity muscular exercise (> 70% VO2max) conducted one hour before a meal causes an anorectic effect at lunch and dinner the same day.
- Trial name
- NCT02664844
- Testing
- Physical activity
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Type 2 Diabetes, Overweight
Effects of Replacing Diet Beverages With Water on Weight Loss and Plasma Glucose Control in Type 2 Diabetes
The purpose of the present study is to evaluate the effect of replacing diet beverages with water on weight loss and biochemical indicators for insulin sensitivity and cardiometabolic risk factors of diabetic obese and overweight…
- Conditions
- Type 2 Diabetes, Overweight, Obese
- Trial name
- NCT02412774
- Testing
- DBs at the end of the main meal + Diet, Water at the end of the main meal+ Diet
- Where
- Iran
- Volunteers
- 81 people
- Sponsor
- Novindiet Clinic
Obesity, Protein-energy; Imbalance
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
The purpose of the study is to determine the effect of three weight loss surgeries compared to a low calorie diet with regard to energy expenditure, body composition, insulin sensitivity, and the response of gastrointestinal…
- Conditions
- Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
- Trial name
- BARIA (NCT00936130)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Pennington Biomedical Research Center
Metabolic Syndrome
Effect of Fish Oil on Markers of the Metabolic Syndrome in Overweight Adolescent Boys
The aim of the study is to investigate if dietary fish oil has a beneficial effect on blood pressure, insulin sensitivity, blood lipid profile, body composition and metabolic rate in healthy, but slightly overweight, teenage…
- Trial name
- TeenFisk (NCT00929552)
- Testing
- Dietary oils (fish, vegetable oil)
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Type 2 Diabetes Mellitus
Changes in Insulin Sensitivity After Weight Loss
This study is designed to compare the changes in insulin sensitivity as well as gastrointestinal hormone levels in diabetic and non-diabetic obese individuals who are undergoing weight loss procedures.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NCT00627484
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity, Morbid, Insulin Sensitivity
Predictors of Weight Loss and Metabolic Health After Bariatric Surgery
In this prospective study the investigators aim to identify preoperative predictors of improvement of metabolic health and weight loss after bariatric surgery focusing on inflammation, insulin sensitivity (in a subgroup of…
- Conditions
- Obesity, Morbid, Insulin Sensitivity, Bariatric Surgery Candidate, Feeding Behavior
- Trial name
- NCT05987631
- Where
- 3 sites in Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Insulin Resistance
Effect of Weight Loss on Brain Insulin Sensitivity in Humans
Obesity if known to be associated with brain insulin resistance in humans. This condition has not only implication for the brain but also for whole-body energy homeostasis.
- Trial name
- NCT02991365
- Testing
- nasal insulin
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Polycystic Ovary Syndrome, Obesity
Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity
The goal of this clinical trial is to study the effects of a intensive weight loss program (STREAM) in patients living with PCOS.
- Trial name
- FLOWERS-PCOS (NCT06325449)
- Testing
- STREAM program
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Fatty Liver, Insulin Resistance
Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD
To assess whether reversal of fatty liver by moderate weight loss (8% of body weight) will lead to improvements in insulin sensitivity, which will be associated with changes in both glucose status and lipid profiles, in obese…
- Trial name
- NCT00585299
- Testing
- Low-fat diet, Traditional diet
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes, Overweight
Effects of Replacing Diet Beverages With Water on Weight Maintenance of Type 2 Diabetic Obese Women: 18 Months Follow up
the present study aimed to follow up our participants in order to consider the changes in weight and anthropometric measurements after the 12-month weight maintenance as well as the total of 18 months, consisting of the…
- Conditions
- Type 2 Diabetes, Overweight, Obese
- Trial name
- NCT03726762
- Testing
- DBs at the end of the main meal + weight control program, Water at the end of the main meal+ weight control program
- Where
- Iran
- Volunteers
- 81 people
- Sponsor
- Novindiet Clinic
Obesity, Metabolic Syndrome
Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status
The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.
- Conditions
- Obesity, Metabolic Syndrome, Hyperuricemia
- Trial name
- UA (NCT01931527)
- Testing
- Rasburicase
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia