Clinical trials: Weight Regain
Obesity
Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Many people who have bariatric (weight-loss) surgery do not lose as much weight as expected, or they regain weight over time. This study will test whether a medicine called tirzepatide can help these patients lose more weight and…
- Trial name
- TirBaS (NCT07829198)
- Testing
- Tirzepatide
- Where
- 3 sites in Portugal
- Volunteers
- 70 people
- Sponsor
- Universidade do Porto
Dilatation of Anastomosis, Bypass Complication
Carbon Dioxide Versus Air Insufflation for the Application of Argon Plasma to Reduce the Gastrojejunal Anastomosis
The objective of this randomized clinical trial is to compare pain levels during and after insufflation with carbon dioxide or in subjects that will undergo endoscopic fulguration with argon to reduce the diameter of the…
- Conditions
- Dilatation of Anastomosis, Bypass Complication, Obesity
- Trial name
- NCT03264027
- Testing
- Carbon dioxide, Ambient air, Argon fulguration
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Kaiser Clinic and Hospital
Obesity
Using the Energy Gap to Prevent Weight Regain
The major challenge in obesity treatment is not producing weight loss but in preventing that weight from being regained. There are many different methods to lose weight, but there are no recommendations for how you can best…
- Trial name
- Lose-It (NCT00429650)
- Testing
- increased exercise, diet, Exercise and Diet
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Weight Loss, Weight Gain
Role Of Metabolic Adaptation In Weight Regain
In a previous study (NCT04081337), 55 participants with obesity participated on a 18-week lifestyle intervention to reduce their body weight, targeting 10% body weight loss.
- Conditions
- Weight Loss, Weight Gain, Obesity
- Trial name
- EXPEND-FU (NCT05766358)
- Testing
- Intensive lifestyle change therapy, Tirzepatide
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Pennington Biomedical Research Center
Obesity, Overweight
Weight Regain After Consumption of Food Supplement and Interventional Diet Program
Effect of the dietary supplement (FAT-BINDER DAMM) on weight regain after 9 months of control weight program
- Conditions
- Obesity, Overweight, Weight Loss, Body Weight Changes
- Trial name
- fat-binder (NCT03554525)
- Testing
- Fat-binder damm
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Obesity
Mindfulness and Compassion-based Programs on Food Behavior of Patients With Weight Regain After Bariatric Surgery
Weight regain in patients after bariatric surgery has been reported as one of the main failure factors of these surgeries, has important health consequences, such as the return of associated comorbidities, and, until that moment…
- Trial name
- NCT04171713
- Testing
- Mindfulness-Based Health Promotion + Treatment as usual, Attachment-based compassion therapy + Treatment as usual, Treatment as usual
- Where
- Brazil
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Obesity
Remote Intervention for Weight Regain After Sleeve Gastrectomy
The study is designed to assess the effect of a 3-month remote comprehensive intervention program by a multidisciplinary team combined with mobile supportive text messages aimed to raise the level of happiness and subjective…
- Trial name
- NCT05122013
- Testing
- A comprehensive remote multidisciplinary intervention for weight regain after sleeve gastrectomy, Control group
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Obesity, Morbid, Weight Gain
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass.
- Trial name
- DISCOURSE (NCT04894838)
- Testing
- Distal gastric bypass
- Where
- 8 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Energy Expenditure
Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss
Background: Many people regain the weight they lose through diet and exercise. This might happen because the weight loss slows their metabolism. This slowing is called metabolic adaptation.
- Trial name
- NCT02544009
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Bariatric Surgery Candidate
Diet-induced Thermogenesis in Patients With Postoperative Roux-in-Y Gastric Bypass (RYGBP) Weight Regain
Introduction: According to the National Health and Nutrition Examination Survey 2009-2010, 78 million American adults are obese.
- Conditions
- Obesity, Bariatric Surgery Candidate, Protein-energy; Imbalance
- Trial name
- RYGBP (NCT02422212)
- Testing
- patients eat a mixed solid meal
- Where
- 3 sites in Brazil
- Volunteers
- 45 people
- Sponsor
- Silvia Leite Faria
Weight Regain
Risk Factors Affect Weight Loss Outcomes After Treatment.
The treatment for weight loss was more diverse due to the higher prevalence of obesity. In addition to weight loss medications, many patients seek bariatric surgery to treat obesity.
- Trial name
- WRRFA (NCT06482411)
- Where
- Taiwan
- Volunteers
- 3,602 people
- Sponsor
- E-DA Hospital
Obesity
Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation
This study will compare the effect of orforglipron and phentermine on weight maintenance.
- Trial name
- NCT07729332
- Testing
- Phentermine Pill, Orforglipron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Healthy Volunteers
Metabolic and Neural Adaptations to Weight Loss, Plateau, and Regain
Background: Many people can lose weight by changing their diet or exercise. However, most people eventually regain the weight over time.
- Trial name
- NCT02199483
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Roux-en-Y Gastric Bypass and Weight Regain
This study compares eating behaviors, meal size, and the size of the gastric pouch and connection between the gastric pouch and small intestine in patients who had gastric bypass surgery two or more years ago and regained weight…
- Trial name
- NCT02302898
- Testing
- Eating Behavior Evaluation, Measurement of Functional gastric volume, Measurement of gastric pouch and GJ size
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Bariatric Surgery Candidate, Obesity, Morbid
Volumetric Pouch Study After Laparoscopic Sleeve Gastrectomy
This study aimed to evaluate Laparoscopic Sleeve Gastrectomy in the treatment of morbidly obese patients pre and post-operatively after 3 months, 6 months, and 1-year follow-up and assess the volumetric changes of the gastric…
- Trial name
- NCT04880902
- Testing
- sleeve gastrectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Behavioral, Activity
Weight Regain Study After Bariatric Surgery-A Pilot Project
There are three different phases to this study: 1. Screening phase to determine if you are eligible to participate in the study. 2.
- Conditions
- Behavioral, Activity, Weight Loss
- Trial name
- NCT02754453
- Testing
- Behavioral lifestyle intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Bariatric Surgery and Physical Activity
A High-Intensity Exercise Program in Post-Bariatric Patients
Background: Weight regain is one of the most common problems in bariatric patients. Although exercise contributes to maintaining weight, there are currently few studies performed on this population.
- Trial name
- NCT03603392
- Testing
- Physical activity program
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Obesity, Morbid, Weight Gain
Transit Bipartition After Sleeve Gastrectomy
Retrospective analysis of 100 morbidly obese patients who underwent a transit bipartition (TB) procedure ("Single Anastomosis Sleeve Ileal bypass") for inadequate weight loss or weight recidivism after a previous sleeve…
- Conditions
- Obesity, Morbid, Weight Gain, Bariatric Surgery Candidate
- Trial name
- TB-LSG (NCT04782648)
- Testing
- transit bipartition
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ruhr University of Bochum
Obesity, Morbid, Bariatric Surgery Candidate
Trends and Safety in Revisional Bariatric Surgery in Italy
Background: Revisional bariatric surgery (RBS) represents a further solution for patients who experience an inadequate response following initial bariatric surgery or significant weight regain following an initial satisfactory…
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, Remission, Complication,Postoperative
- Trial name
- NCT05194943
- Testing
- revisional bariatric surgical procedures
- Where
- 11 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Obesity, Weight Gain
Role of Dairy Products in Weight Maintenance
The goal of the current study is to determine the role of dairy in similarly preventing weight and fat re-gain in obese adults who have successfully completed a weight loss diet program.240 obese subjects will undergo a…
- Trial name
- NCT00686426
- Testing
- Dairy Foods
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Tennessee