Clinical trials: Weight Regain
Obesity
Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation
This study will compare the effect of orforglipron and phentermine on weight maintenance.
- Trial name
- NCT07729332
- Testing
- Phentermine Pill, Orforglipron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Obesity
Time-Restricted Eating as a Potential Strategy to Promote Weight Loss Maintenance in Patients With Obesity
While body weight reduction can be achieved through various interventions in people living with obesity, most patients regain a substantial proportion of the lost weight within the following months.
- Trial name
- REGANE (NCT07315659)
- Testing
- Calorie restriction (Dietary intervention), Regular eating window, Time-restricted eating
- Where
- Spain
- Volunteers
- 212 people
- Sponsor
- Universidad de Granada
Obesity, Morbid, Weight Gain
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass.
- Trial name
- DISCOURSE (NCT04894838)
- Testing
- Distal gastric bypass
- Where
- 8 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Dilatation of Anastomosis, Bypass Complication
Carbon Dioxide Versus Air Insufflation for the Application of Argon Plasma to Reduce the Gastrojejunal Anastomosis
The objective of this randomized clinical trial is to compare pain levels during and after insufflation with carbon dioxide or in subjects that will undergo endoscopic fulguration with argon to reduce the diameter of the…
- Conditions
- Dilatation of Anastomosis, Bypass Complication, Obesity
- Trial name
- NCT03264027
- Testing
- Carbon dioxide, Ambient air, Argon fulguration
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Kaiser Clinic and Hospital
Obesity
Post-Bariatric Weight Regain Behavioral Intervention
This project aims to evaluate a newly developed Internet-delivered (via e-learning modules) acceptance-based behavioral intervention (ABTi) for individuals who are experiencing weight regain after bariatric surgery.
- Trial name
- NCT03564392
- Testing
- Acceptance Based Behavioral Intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Rush University Medical Center
Obesity
A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program.
- Trial name
- POWERS (NCT05748158)
- Testing
- Weight loss
- Where
- 3 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Pittsburgh
Obesity and Obesity-related Medical Conditions, Weight Regain
The Application of Gastric Bypass Stents in Patients with Weight Regain After Laparoscopic Sleeve Gastrectomy：a Feasibility Study
This study is based on the National Center for Integrated Traditional Chinese and Western Medicine, utilizing the centralized advantages of our department and integrating multiple disciplines (general surgery, endocrinology…
- Trial name
- DJBL for LSG (NCT06801496)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Weight Loss, Weight Regain
Testing a Tailored Approach to Long-Term Weight Loss Success
The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight.
- Conditions
- Weight Loss, Weight Regain, Obesity & Overweight
- Trial name
- NCT07577765
- Testing
- Adaptive weight regain prevention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Laparoscopic Ileal Interposition and Weight Regain
The investigators will study the Ileal interposition to the treatment of weight regain after Roux-en-Y gastric bypass, assessing weight loss, body composition, quality of life, metabolic biomarkers, inflammatory biomarkers, and…
- Trial name
- NCT05931939
- Testing
- Ileal Interposition, Traditional surgical technique
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Rio de Janeiro State University
Bariatric Surgery Candidate, Obesity, Morbid
Volumetric Pouch Study After Laparoscopic Sleeve Gastrectomy
This study aimed to evaluate Laparoscopic Sleeve Gastrectomy in the treatment of morbidly obese patients pre and post-operatively after 3 months, 6 months, and 1-year follow-up and assess the volumetric changes of the gastric…
- Trial name
- NCT04880902
- Testing
- sleeve gastrectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Obesity
Dietary Treatment for Post Bariatric Weight Regain
Metabolic surgery has, among all obesity treatments, the best long term efficacy, but weight regain (weight regain, WR) or insufficient weight loss (IWL) are relatively common.
- Trial name
- WRKD (NCT05896358)
- Testing
- ketogenic diet
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Obesity
Computer Intervention for Prevention of Weight Regain
Many overweight patients are able to lose weight successfully, but then regain their weight. The purpose of this study is to develop and test the efficacy of 2 interventions to prevent weight regain in individuals who have…
- Trial name
- NCT00067145
- Testing
- Face-to-face maintenance program, Internet maintenance program
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obese Patients With Bariatric Surgery, Obese Patients (BMI ≥ 30 kg/m²)
Interventions for Weight Regain After Bariatric Surgery
Study Objective: The aim of this study is to evaluate the effects of revisional bariatric surgery (RBS), very low-calorie ketogenic diet (VLCKD), and intermittent fasting (IF) on nutritional habits and clinical outcomes…
- Conditions
- Obese Patients With Bariatric Surgery, Obese Patients (BMI ≥ 30 kg/m²), Weight Regain Post Bariatric Surgery, Revisional Bariatric Surgery
- Trial name
- NCT06963437
- Testing
- Diet, Ketogenic diet, Fasting
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Medipol University
Behavioral, Activity
Weight Regain Study After Bariatric Surgery-A Pilot Project
There are three different phases to this study: 1. Screening phase to determine if you are eligible to participate in the study. 2.
- Conditions
- Behavioral, Activity, Weight Loss
- Trial name
- NCT02754453
- Testing
- Behavioral lifestyle intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Obesity, Overweight
Weight Regain Treatment Post-Bariatric Surgery
This study will examine behavioral and pharmacologic (Naltrexone+Bupropion) treatments for weight regain after bariatric surgery.
- Trial name
- NCT04662801
- Testing
- Behavioral Weight Loss (BWL), Early Responder: BWL continued, Early Non-responder: BWL continued with medication added
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Obesity
Mindfulness and Compassion-based Programs on Food Behavior of Patients With Weight Regain After Bariatric Surgery
Weight regain in patients after bariatric surgery has been reported as one of the main failure factors of these surgeries, has important health consequences, such as the return of associated comorbidities, and, until that moment…
- Trial name
- NCT04171713
- Testing
- Mindfulness-Based Health Promotion + Treatment as usual, Attachment-based compassion therapy + Treatment as usual, Treatment as usual
- Where
- Brazil
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Severe Obesity
Resting Metabolic Rate is a Predictor of Weight Regain?
he increasing prevalence of obesity in developed countries has also reached Brazil in the last two decades. Conventional treatments are not efficient to sustained weight loss and in some cases, weight reduction in individuals…
- Trial name
- NCT04118582
- Testing
- Body composition and resting metabolic rate analisys
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Metabolic Syndrome, Obesity
Exercise,Metabolic Syndrome and Weight Regain (Echocardiography Substudy)
We plan to test the hypothesis that patients with metabolic syndrome will have impaired left ventricular diastolic parameters. These parameters will be measured before and after a stress test at the end of a 3 month period of…
- Trial name
- NCT00543985
- Testing
- Stress Echocardiography
- Volunteers
- 36 people
- Sponsor
- University of Missouri-Columbia
Overweight and Obesity
Preventing Weight Regain Post-Semaglutide Treatment With Active Fiber Supplement (Soloways)
This randomized, double-blind, placebo-controlled trial titled "Preventing Weight Regain Post-Semaglutide Treatment with Active Fiber Supplement (Soloways)" evaluated the efficacy of an active fiber supplement in preventing…
- Trial name
- PWR-FAST (NCT06221696)
- Testing
- Active Fiber Supplement Group
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- S.LAB (SOLOWAYS)
Weight Regain After Bariatric Surgery and Food Addiction
Effects of Probiotic Supplementation With Weight Reducing Plan in Patients With Food Addiction and Weight Regain After Bariatric Surgery
To study the effects of probiotic supplementation with a weight loss program and cognitive behavioral therapy (CBT) on anthropometric measures, eating behavior, food addiction, and related hormone levels in patients with food…
- Trial name
- NCT06327919
- Testing
- Probiotic supplement
- Where
- 2 sites in Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute