Clinical trials: Weightlessness
Healthy
Human Fine-motor-skills in Weightlessness: Comparison of a Laboratory and an Everyday-like Context
The human performance during weightlessness was tested in a multiplicity of laboratory experiments during parabolic flights and in space.
- Trial name
- FINESKILL (NCT02566213)
- Testing
- Parabolic flight, Motor skills measurements
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Spatial Orientation and Motor Skills: How to Flip Switches "Down" in Weightlessness?
The purpose of the study is to investigate spatial orientation in weightlessness as it manifests not in perception but rather in motor performance by direction and reaction time of flip switch. Hypotheses are that flip switch: 1.
- Trial name
- Down (NCT02850380)
- Testing
- FLIP SWITCHES "DOWN" IN WEIGHTLESSNESS
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Instructional Virtual Realities, Weightlessness Simulation
VR-MARS Virtual Reality, Medical Assistance and Rescue for Space
VRMARS is a medical simulation study in microgravity. Healthy volunteers (n=18) test in microgravity the functionnality of an augmented reality headset in which a medical assistance is displayed.
- Conditions
- Instructional Virtual Realities, Weightlessness Simulation, Space Simulation, Patient Simulation
- Trial name
- VR-MARS (NCT06144658)
- Testing
- Augmented Reality Headset / Hololens 2 or Varjo XR3
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de Bretagne Sud
Simulation of Weightlessness by Anti-Orthostatic Long Term Bed Rest
Toulouse Male Long Term Bed Rest 2001-2002
Microgravity during space flight induces physiological changes that affect astronauts' health and performance. Space flight simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that…
- Trial name
- NCT00311571
- Testing
- Ethidronate, Physical training
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre National d'Etudes Spatiales
Weightlessness, Weightlessness; Adverse Effect
Thigh Cuffs to Prevent the Deconditioning Induced by 5 Days of Dry Immersion
The objective of the study is to investigate whether thigh cuffs help to prevent and/or reduce the deconditioning induced by 5 days of dry immersion and in particular the fluid shift and its related ophthalmological disorders.
- Trial name
- DI-Cuff (NCT03915457)
- Testing
- Dry immersion Control Group, Thigh cuffs intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Anemia, Weightlessness
Causes and Mechanisms of Space Hemolysis At High Altitudes
Anemia is a lack of red blood cells (RBCs) in the circulation. Because RBCs carry the oxygen your body needs to function, anemia can affect one's ability to stay awake, alert, and perform physical activities.
- Trial name
- ANEMIA (NCT05496309)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiovascular Abnormalities, Weightlessness
Electroacupuncture is Effective in Cardiac Deconditioning Induced by Head-down Bed Rest
To investigate the changes of cardiovascular function during short-term simulated weightlessness after electroacupuncture (EA) treatment．
- Trial name
- NCT02300207
- Testing
- electronic acupuncture treatment instrument
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Healthy Volunteers
Validation of Methods for Evaluating Operation Force, Motion and Visual Perception in Weightlessness
Previous studies have neglected two important aspects for the China National Space Administration. First, while biomechanical models are very sensitive to the characteristics of the subjects, data have been collected on subjects…
- Trial name
- HopMot (NCT02508558)
- Testing
- motion perception and locomotor operation performance measurements, parabolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Intubation; Difficult or Failed, Intubation Complication
Evaluation of Two Positions for Free Floating Tracheal Intubation in Weightlessness
In a non-randomized, controlled, cross-over simulation study, the investigators evaluated and compared intubation performance of trained operators, using either a conventional laryngoscope in an ice-pick position or a video…
- Trial name
- NCT05303948
- Testing
- Videolaryngoscopy / Direct Laryngoscopy
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de Bretagne Sud
Weightlessness Simulation
A Comparison Study Between 10 Days of Dry Immersion Versus 10 Days of Head-down Bedrest on 20 Healthy Male Volunteers
The space agencies are actively engaged in studying the physiological adaptation to space environment through studies on board the International Space Station (ISS) but also on the ground.
- Trial name
- VIVALDI 3 (NCT06777329)
- Testing
- 10 days of dry immersion, 10 days of Head Down Bed Rest
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Muscle Atrophy, Weightlessness
The Effects of Whole Body Unloading on Physiological Function
This study is a collaboration between the Centre of Human \& Aerospace Physiological Sciences (CHAPS) and the Sleep and Brain Plasticity Centre (Department of Neuroimaging) at King's College London and the Sleep Disorders Centre…
- Conditions
- Muscle Atrophy, Weightlessness, Sleep Disturbance, Astronaut-Bone Demineralisation Syndrome
- Trial name
- NCT03195348
- Testing
- HBF Bed Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy Volunteers
VISUALIZATION OF THE MICROCIRCULATION IN WEIGHTLESSNESS
During weightlessness, the cardiovascular system is subject to rapid changes which has been demonstrated in studies of short term (Space Shuttle) and long term missions to Skylab, MIR, and the International Space Station…
- Trial name
- µGµScan (NCT03561545)
- Testing
- weightlessness (parabolic flight)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cartilage Degeneration, Weightlessness
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
- Trial name
- NCT06612372
- Testing
- 60-day-6° head-down bed rest
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Radiation Exposure
Suspended Personal Protection System Versus Conventional Protection (Aka Zero-Gravity vs Shield and Apron)
This trial investigates operator radiation doses when performing standardized procedures using two different means of radiation protection, namely conventional lead shield and apron versus suspended protection system…
- Trial name
- NCT04078165
- Testing
- Zero-Gravity, Conventional radiation protection
- Where
- Finland
- Volunteers
- 72 people
- Sponsor
- Helsinki University Central Hospital
Weightlessness, Weightlessness; Adverse Effect
A New Nutritional Countermeasure to Prevent the Deconditioning Induced by 60 Days of Antiorthostatic Bed Rest
The objective of this study is to investigate whether the cocktail of natural antioxidants XXS-2A-BR2 comprising vitamin E and coupled with omega-3 helps to prevent and / or reduce the deleterious effects induced by long term…
- Trial name
- LTBRCocktail (NCT03594799)
- Testing
- Bed Rest Control Group, Cocktail intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Weightlessness
A 5-day Dry Immersion Study on 20 Healthy Male Volunteers
Dry immersion (DI) is a ground-based model of prolonged conditions of simulated microgravity. Dry immersion involves immersing the subject in water covered with an elastic waterproof fabric.
- Trial name
- VIVALDI2 (NCT05493176)
- Testing
- Dry immersion
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Healthy Participants
Human Neutral Body Posture in Weightlessness
The scientific goal of this experiment is to evaluate the performances of our three-dimensional digital model by comparing its prediction computed from underwater data to posture observed during real weightlessness during…
- Trial name
- HYDRONAUT (NCT02563262)
- Testing
- body angles measurements during weightlessness
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Fluid Retention Tissue, Perfusion; Complications
Weightlessness Associated Cephalad Fluid Shifts; The Potential to Evaluate Venous and Lymphatic Dysfunction
In the weightlessness of space and significant alterations of terrestrial 1 g (1 gravity equivalent) head-to-foot hydrostatic pressure gradients, astronauts experience a dramatic fluid redistribution of ~ 2 liters from the legs…
- Trial name
- NIID (NCT06405282)
- Testing
- Manual Lymphatic Drainage, Near infrared spectroscopy, Temperature
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Weightlessness
Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest
Space flight simulation study to study effects of microgravity through bedrest coupled with flight exercise counter-measures.
- Trial name
- FAP (NCT00891449)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)