Clinical trials: Wheat Hypersensitivity
Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome)
NCWS or IBS/FD in Relatives of CD Patients
Over 50% of non-celiac wheat sensitivity (NCWS) patients are HLA DQ2/DQ8 positive and often have a Celiac Disease (CD) family history.
- Conditions
- Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome), Functional Dyspepsia, Celiac Disease
- Trial name
- NCT07584473
- Testing
- Wheat-Free Diet
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- University of Palermo
Wheat Allergy
Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy
This is an observational pilot study investigating the effectiveness, safety and specific immunological mechanisms of Specific Oral Tolerance Induction (SOTI) in children with IgE-mediated wheat allergy.
- Trial name
- NCT03352193
- Testing
- Wheat spaghetti
- Where
- Greece
- Volunteers
- 15 people
- Sponsor
- Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
Inflammatory Back Pain
Inflammatory Back Pain and Gluten Free Diet
Articular involvement is the most frequent extra-intestinal manifestation of inflammatory bowel diseases (IBD). IBD-related spondyloarthropathy is mainly characterised by axial involvement (including inflammatory back pain…
- Trial name
- NCT03017716
- Testing
- Gluten free diet
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Non-Celiac Wheat Sensitivity
Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients
Celiac disease (CD) is an immune-based reaction to dietary gluten (storage protein for wheat, barley, and rye) that primarily affects the small intestine in genetically predisposed patients and resolves with exclusion of gluten…
- Trial name
- NCT02248545
- Where
- 3 sites in Italy
- Volunteers
- 90 people
- Sponsor
- University of Palermo
Non-Celiac Wheat Sensitivity
Non-Celiac Wheat Sensitivity: Permanent or Transient Condition?
Non-Celiac Gluten Sensitivity (NCGS) has been recently included among the gluten-related diseases. Patients suffering from NCGS are diagnosed after carefully excluding celiac disease (CD), and immunoglobulin E (IgE)-mediated…
- Trial name
- NCT02823522
- Testing
- Patients recruitment
- Where
- 2 sites in Italy
- Volunteers
- 280 people
- Sponsor
- University of Palermo
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Non-celiac Gluten Sensitivity
Tolerability of an Ancient Grain in Patients With Non-Celiac Wheat Sensitivity
Patients suffering from wheat-related troubles, in absence of celiac disease or wheat allergy diagnosis, can suffer from non-celiac wheat sensitivity (NCWS).
- Trial name
- NCT06191432
- Testing
- Administration of Triticum Monococcum flour, Administration of Triticum Aestivum flour
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Palermo
Non-celiac Gluten Sensitivity, Anemia
Anemia in Non-celiac Wheat Sensitivity
In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT04377061
- Testing
- Evaluation of anemia
- Where
- 3 sites in Italy
- Volunteers
- 244 people
- Sponsor
- University of Palermo
Food Allergy
Open-label Extension Study of ADP101
This is an open-label, safety extension study for participants who participated in the Harmony study (protocol ADP101-MA-01).
- Trial name
- NCT05243719
- Testing
- ADP101
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Alladapt Immunotherapeutics, Inc.
Irritable Bowel Syndrome, Wheat Sensitivity
Effects of Wheat Breads on Symptoms of IBS, a Pilot Study
This is randomized pilot study comparing tolerability of yeast-baked wheat bread and sourdough wheat bread in irritable bowel syndrome.
- Trial name
- Wheat-IBS (NCT02572908)
- Testing
- Sourdough wheat bread, Regular yeast baked toast bread, Gluten-free diet
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Oy Karl Fazer Ab
Not-celiac Wheat Sensitivity (NCWS), Familial Mediterranean Fever (FMF)
Gluten-related Disorders in Familial Mediterranean Fever Patients
It is known that the gluten-containing grains can be responsible for human diseases related to gluten exposure. These forms of gluten intolerance represent a heterogeneous set of conditions, including celiac disease (CD), wheat…
- Trial name
- NCT03563300
- Testing
- Wheat flour
- Where
- 2 sites in Italy
- Volunteers
- 8 people
- Sponsor
- University of Palermo
Wheat Allergy
Oral Immunotherapy for Wheat Allergy
This study is being done to learn about the medical effects, the safety, and the immunologic effects of Wheat Oral Immunotherapy (OIT) treatment.
- Trial name
- Wheat OIT (NCT01980992)
- Testing
- Wheat OIT
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Hugh A Sampson, MD
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity
Liver Steatosis and Fibrosis in Non-Celiac Wheat Sensitivity Patients: a Prospective Study
Hypothesizing an intestinal barrier impairment as a common pathophysiological substrate of both Non Celiac Wheat Sensitivity (NCWS) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD), in a retrospective cohort…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT07750535
- Testing
- Prevalence and severity of liver steatosis and fibrosis,
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Palermo
Asthma, Sensitization
Evaluation of Grass Pollen Sensitization Among Professionals Exposed or Not Exposed to Flour
Occupational asthma are a major etiology of allergic asthma, especially among manual labor. The baker job exposes to significant level of flour.
- Trial name
- GRAMIPRO (NCT06727825)
- Where
- France
- Volunteers
- 403 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Wheat Allergy
Luminex-based Assay to Identify Major IgE-binding Episode Among IgE-mediated Wheat-allergic Patient
This study will be using Luminex-based peptide assay (LPA) to determine major IgE-binding epitope among wheat allergic children to differentiate clinical phenotype.
- Trial name
- NCT04100122
- Testing
- Blood drawing
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Food Allergy, Wheat Allergy
Evaluation of Potential Allergenicity of New Wheat Varieties
The goal of the study is to determine accurate blood test levels that can predict whether or not subjects are truly allergic to certain foods.
- Trial name
- NCT02341040
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-celiac Wheat Sensitivity
KIR Genes and Non-Celiac Wheat Sensitivity
Non-celiac gluten sensitivity (NCGS) is a condition characterized by gastrointestinal and extraintestinal symptoms which are triggered by gluten ingestion in the absence of celiac disease (CD) and wheat allergy.
- Trial name
- NCT05469971
- Testing
- KIR genotyping
- Where
- 4 sites in Italy
- Volunteers
- 170 people
- Sponsor
- University of Palermo
Non-celiac Wheat Sensitivity
Gynaecological Disorders in Not-celiac Wheat Sensitivity
In the last few years, a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or…
- Trial name
- NCT03027492
- Testing
- Gluten free diet, NCWS open challenge with wheat
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Palermo
Familial Mediterranean Fever, Non-celiac Gluten Sensitivity
Can Gluten/Wheat or Other Foods be Responsible for FMF Attacks
Familial Mediterranean Fever (FMF) is a chronic hereditary autoinflammatory disease caused by mutations in the MEditerranean FeVer (MEFV) gene which codes for pyrin.
- Trial name
- NCT06338891
- Testing
- Main questionnaire, Secondary questionnaire
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Palermo
Allergy;Food, Wheat Allergy
Randomized Controlled Trial for Wheat Oral Immunotherapy
IgE-mediated wheat allergy is a growing allergy problem in children, and affected children can predict with immediate-type allergic reactions to the extent of anaphylactic shock.
- Conditions
- Allergy;Food, Wheat Allergy, Children
- Trial name
- WOIT-RCT (NCT06069492)
- Testing
- Wheat-containing food
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong